Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 83

1.

A novel structurally characterized haloacid dehalogenase superfamily phosphatase from Thermococcus thioreducens with diverse substrate specificity.

Havlickova P, Brinsa V, Brynda J, Pachl P, Prudnikova T, Mesters JR, Kascakova B, Kuty M, Pusey ML, Ng JD, Rezacova P, Kuta Smatanova I.

Acta Crystallogr D Struct Biol. 2019 Aug 1;75(Pt 8):743-752. doi: 10.1107/S2059798319009586. Epub 2019 Jul 30.

PMID:
31373573
2.

Investigation of flexibility of neuraminidase 150-loop using tamiflu derivatives in influenza A viruses H1N1 and H5N1.

Zima V, Albiñana CB, Rojíková K, Pokorná J, Pachl P, Řezáčová P, Hudlicky J, Navrátil V, Majer P, Konvalinka J, Kožíšek M, Machara A.

Bioorg Med Chem. 2019 Jul 1;27(13):2935-2947. doi: 10.1016/j.bmc.2019.05.024. Epub 2019 May 17.

PMID:
31128993
3.

Crystal structure of the cold-adapted haloalkane dehalogenase DpcA from Psychrobacter cryohalolentis K5.

Tratsiak K, Prudnikova T, Drienovska I, Damborsky J, Brynda J, Pachl P, Kuty M, Chaloupkova R, Rezacova P, Kuta Smatanova I.

Acta Crystallogr F Struct Biol Commun. 2019 May 1;75(Pt 5):324-331. doi: 10.1107/S2053230X19002796. Epub 2019 Apr 24.

PMID:
31045561
4.

3,5,7-Substituted Pyrazolo[4,3- d]pyrimidine Inhibitors of Cyclin-Dependent Kinases and Their Evaluation in Lymphoma Models.

Jorda R, Havlíček L, Šturc A, Tušková D, Daumová L, Alam M, Škerlová J, Nekardová M, Peřina M, Pospíšil T, Široká J, Urbánek L, Pachl P, Řezáčová P, Strnad M, Klener P, Kryštof V.

J Med Chem. 2019 May 9;62(9):4606-4623. doi: 10.1021/acs.jmedchem.9b00189. Epub 2019 Apr 17.

PMID:
30943029
5.

Capturing a dynamically interacting inhibitor by paramagnetic NMR spectroscopy.

Srb P, Svoboda M, Benda L, Lepšík M, Tarábek J, Šícha V, Grüner B, Grantz-Šašková K, Brynda J, Řezáčová P, Konvalinka J, Veverka V.

Phys Chem Chem Phys. 2019 Mar 6;21(10):5661-5673. doi: 10.1039/c9cp00416e.

PMID:
30794275
6.

The structure and function of Iristatin, a novel immunosuppressive tick salivary cystatin.

Kotál J, Stergiou N, Buša M, Chlastáková A, Beránková Z, Řezáčová P, Langhansová H, Schwarz A, Calvo E, Kopecký J, Mareš M, Schmitt E, Chmelař J, Kotsyfakis M.

Cell Mol Life Sci. 2019 May;76(10):2003-2013. doi: 10.1007/s00018-019-03034-3. Epub 2019 Feb 12.

PMID:
30747251
7.

DNA-linked inhibitor antibody assay (DIANA) as a new method for screening influenza neuraminidase inhibitors.

Kožíšek M, Navrátil V, Rojíková K, Pokorná J, Berenguer Albiñana C, Pachl P, Zemanová J, Machara A, Šácha P, Hudlický J, Císařová I, Řezáčová P, Konvalinka J.

Biochem J. 2018 Dec 10;475(23):3847-3860. doi: 10.1042/BCJ20180764.

8.

Crystal structure of native α-L-rhamnosidase from Aspergillus terreus.

Pachl P, Škerlová J, Šimčíková D, Kotik M, Křenková A, Mader P, Brynda J, Kapešová J, Křen V, Otwinowski Z, Řezáčová P.

Acta Crystallogr D Struct Biol. 2018 Nov 1;74(Pt 11):1078-1084. doi: 10.1107/S2059798318013049. Epub 2018 Oct 29.

PMID:
30387766
9.

Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation.

Sharma S, Čermáková K, De Rijck J, Demeulemeester J, Fábry M, El Ashkar S, Van Belle S, Lepšík M, Tesina P, Duchoslav V, Novák P, Hubálek M, Srb P, Christ F, Řezáčová P, Hodges HC, Debyser Z, Veverka V.

Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):E7053-E7062. doi: 10.1073/pnas.1803909115. Epub 2018 Jul 11.

10.

Kinetic, Thermodynamic, and Structural Analysis of Drug Resistance Mutations in Neuraminidase from the 2009 Pandemic Influenza Virus.

Pokorná J, Pachl P, Karlukova E, Hejdánek J, Řezáčová P, Machara A, Hudlický J, Konvalinka J, Kožíšek M.

Viruses. 2018 Jun 21;10(7). pii: E339. doi: 10.3390/v10070339.

11.

In situ proteolysis of an N-terminal His tag with thrombin improves the diffraction quality of human aldo-keto reductase 1C3 crystals.

Plavša JJ, Řezáčová P, Kugler M, Pachl P, Brynda J, Voburka Z, Ćelić A, Petri ET, Škerlová J.

Acta Crystallogr F Struct Biol Commun. 2018 May 1;74(Pt 5):300-306. doi: 10.1107/S2053230X18005721. Epub 2018 Apr 24.

PMID:
29717998
12.

Relapsed acute lymphoblastic leukemia-specific mutations in NT5C2 cluster into hotspots driving intersubunit stimulation.

Hnízda A, Fábry M, Moriyama T, Pachl P, Kugler M, Brinsa V, Ascher DB, Carroll WL, Novák P, Žaliová M, Trka J, Řezáčová P, Yang JJ, Veverka V.

Leukemia. 2018 Jun;32(6):1393-1403. doi: 10.1038/s41375-018-0073-5. Epub 2018 Feb 25.

PMID:
29535428
13.

Ranking Power of the SQM/COSMO Scoring Function on Carbonic Anhydrase II-Inhibitor Complexes.

Pecina A, Brynda J, Vrzal L, Gnanasekaran R, Hořejší M, Eyrilmez SM, Řezáč J, Lepšík M, Řezáčová P, Hobza P, Majer P, Veverka V, Fanfrlík J.

Chemphyschem. 2018 Apr 5;19(7):873-879. doi: 10.1002/cphc.201701104. Epub 2018 Feb 19.

PMID:
29316128
14.

Crystal structure of native β-N-acetylhexosaminidase isolated from Aspergillus oryzae sheds light onto its substrate specificity, high stability, and regulation by propeptide.

Škerlová J, Bláha J, Pachl P, Hofbauerová K, Kukačka Z, Man P, Pompach P, Novák P, Otwinowski Z, Brynda J, Vaněk O, Řezáčová P.

FEBS J. 2018 Feb;285(3):580-598. doi: 10.1111/febs.14360. Epub 2017 Dec 30.

15.

Structural basis of the interaction between the putative adhesion-involved and iron-regulated FrpD and FrpC proteins of Neisseria meningitidis.

Sviridova E, Rezacova P, Bondar A, Veverka V, Novak P, Schenk G, Svergun DI, Kuta Smatanova I, Bumba L.

Sci Rep. 2017 Jan 13;7:40408. doi: 10.1038/srep40408.

16.

Oligomeric interface modulation causes misregulation of purine 5´-nucleotidase in relapsed leukemia.

Hnízda A, Škerlová J, Fábry M, Pachl P, Šinalová M, Vrzal L, Man P, Novák P, Řezáčová P, Veverka V.

BMC Biol. 2016 Oct 19;14(1):91.

17.

Kinetic, thermodynamic and structural analysis of tamiphosphor binding to neuraminidase of H1N1 (2009) pandemic influenza.

Albiñana CB, Machara A, Řezáčová P, Pachl P, Konvalinka J, Kožíšek M.

Eur J Med Chem. 2016 Oct 4;121:100-109. doi: 10.1016/j.ejmech.2016.05.016. Epub 2016 May 7.

PMID:
27236066
18.

Atomic resolution crystal structure of Sapp2p, a secreted aspartic protease from Candida parapsilosis.

Dostál J, Pecina A, Hrušková-Heidingsfeldová O, Marečková L, Pichová I, Řezáčová P, Lepšík M, Brynda J.

Acta Crystallogr D Biol Crystallogr. 2015 Dec 1;71(Pt 12):2494-504. doi: 10.1107/S1399004715019392. Epub 2015 Nov 27.

PMID:
26627656
19.

Carbonic anhydrase inhibitors: Design, synthesis and structural characterization of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms.

Buemi MR, De Luca L, Ferro S, Bruno E, Ceruso M, Supuran CT, Pospíšilová K, Brynda J, Řezáčová P, Gitto R.

Eur J Med Chem. 2015 Sep 18;102:223-32. doi: 10.1016/j.ejmech.2015.07.049. Epub 2015 Jul 31.

PMID:
26276436
20.

Multiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motif.

Tesina P, Čermáková K, Hořejší M, Procházková K, Fábry M, Sharma S, Christ F, Demeulemeester J, Debyser Z, Rijck J, Veverka V, Řezáčová P.

Nat Commun. 2015 Aug 6;6:7968. doi: 10.1038/ncomms8968.

PMID:
26245978
21.

Molecular mechanism for the action of the anti-CD44 monoclonal antibody MEM-85.

Škerlová J, Král V, Kachala M, Fábry M, Bumba L, Svergun DI, Tošner Z, Veverka V, Řezáčová P.

J Struct Biol. 2015 Aug;191(2):214-23. doi: 10.1016/j.jsb.2015.06.005. Epub 2015 Jun 9.

PMID:
26066970
22.

Triggering HIV polyprotein processing by light using rapid photodegradation of a tight-binding protease inhibitor.

Schimer J, Pávová M, Anders M, Pachl P, Šácha P, Cígler P, Weber J, Majer P, Řezáčová P, Kräusslich HG, Müller B, Konvalinka J.

Nat Commun. 2015 Mar 9;6:6461. doi: 10.1038/ncomms7461.

23.

Optimization of the crystallizability of a single-chain antibody fragment.

Škerlová J, Král V, Fábry M, Sedláček J, Veverka V, Rezáčová P.

Acta Crystallogr F Struct Biol Commun. 2014 Dec 1;70(Pt 12):1701-6. doi: 10.1107/S2053230X1402247X. Epub 2014 Nov 14.

24.

Activation route of the Schistosoma mansoni cathepsin B1 drug target: structural map with a glycosaminoglycan switch.

Jílková A, Horn M, Řezáčová P, Marešová L, Fajtová P, Brynda J, Vondrášek J, McKerrow JH, Caffrey CR, Mareš M.

Structure. 2014 Dec 2;22(12):1786-1798. doi: 10.1016/j.str.2014.09.015. Epub 2014 Nov 13.

25.

Carborane-based carbonic anhydrase inhibitors: insight into CAII/CAIX specificity from a high-resolution crystal structure, modeling, and quantum chemical calculations.

Mader P, Pecina A, Cígler P, Lepšík M, Šícha V, Hobza P, Grüner B, Fanfrlík J, Brynda J, Řezáčová P.

Biomed Res Int. 2014;2014:389869. doi: 10.1155/2014/389869. Epub 2014 Sep 18.

26.

Structural basis for inhibition of mycobacterial and human adenosine kinase by 7-substituted 7-(Het)aryl-7-deazaadenine ribonucleosides.

Snášel J, Nauš P, Dostál J, Hnízda A, Fanfrlík J, Brynda J, Bourderioux A, Dušek M, Dvořáková H, Stolaříková J, Zábranská H, Pohl R, Konečný P, Džubák P, Votruba I, Hajdúch M, Rezáčová P, Veverka V, Hocek M, Pichová I.

J Med Chem. 2014 Oct 23;57(20):8268-79. doi: 10.1021/jm500497v. Epub 2014 Oct 8.

PMID:
25259627
27.

Conformationally constrained nucleoside phosphonic acids--potent inhibitors of human mitochondrial and cytosolic 5'(3')-nucleotidases.

Šimák O, Pachl P, Fábry M, Buděšínský M, Jandušík T, Hnízda A, Skleničková R, Petrová M, Veverka V, Řezáčová P, Brynda J, Rosenberg I.

Org Biomol Chem. 2014 Oct 28;12(40):7971-82. doi: 10.1039/c4ob01332h. Epub 2014 Sep 1.

PMID:
25178098
28.

Validation and structural characterization of the LEDGF/p75-MLL interface as a new target for the treatment of MLL-dependent leukemia.

Cermáková K, Tesina P, Demeulemeester J, El Ashkar S, Méreau H, Schwaller J, Rezáčová P, Veverka V, De Rijck J.

Cancer Res. 2014 Sep 15;74(18):5139-51. doi: 10.1158/0008-5472.CAN-13-3602. Epub 2014 Jul 31.

29.

Structural and functional analysis of a novel haloalkane dehalogenase with two halide-binding sites.

Chaloupkova R, Prudnikova T, Rezacova P, Prokop Z, Koudelakova T, Daniel L, Brezovsky J, Ikeda-Ohtsubo W, Sato Y, Kuty M, Nagata Y, Kuta Smatanova I, Damborsky J.

Acta Crystallogr D Biol Crystallogr. 2014 Jul;70(Pt 7):1884-97. doi: 10.1107/S1399004714009018. Epub 2014 Jun 29.

PMID:
25004965
30.

Structure of the effector-binding domain of deoxyribonucleoside regulator DeoR from Bacillus subtilis.

Škerlová J, Fábry M, Hubálek M, Otwinowski Z, Rezáčová P.

FEBS J. 2014 Sep;281(18):4280-92. doi: 10.1111/febs.12856. Epub 2014 Jun 25.

31.

Thermodynamic and structural analysis of HIV protease resistance to darunavir - analysis of heavily mutated patient-derived HIV-1 proteases.

Kožíšek M, Lepšík M, Grantz Šašková K, Brynda J, Konvalinka J, Rezáčová P.

FEBS J. 2014 Apr;281(7):1834-47. doi: 10.1111/febs.12743.

32.

Structures of human cytosolic and mitochondrial nucleotidases: implications for structure-based design of selective inhibitors.

Pachl P, Fábry M, Rosenberg I, Simák O, Rezáčová P, Brynda J.

Acta Crystallogr D Biol Crystallogr. 2014 Feb;70(Pt 2):461-70. doi: 10.1107/S1399004713030502. Epub 2014 Jan 29.

PMID:
24531480
33.

Kinetic and structural characterization of an alternatively spliced variant of human mitochondrial 5'(3')-deoxyribonucleotidase.

Pachl P, Fábry M, Veverka V, Brynda J, Řezáčová P.

J Enzyme Inhib Med Chem. 2015 Feb;30(1):63-8. doi: 10.3109/14756366.2013.879577. Epub 2014 Feb 10.

PMID:
24506201
34.

Carborane-based carbonic anhydrase inhibitors.

Brynda J, Mader P, Šícha V, Fábry M, Poncová K, Bakardiev M, Grüner B, Cígler P, Řezáčová P.

Angew Chem Int Ed Engl. 2013 Dec 16;52(51):13760-3. doi: 10.1002/anie.201307583. Epub 2013 Nov 4.

PMID:
24307504
35.

QM/MM calculations reveal the different nature of the interaction of two carborane-based sulfamide inhibitors of human carbonic anhydrase II.

Pecina A, Lepšík M, Řezáč J, Brynda J, Mader P, Řezáčová P, Hobza P, Fanfrlík J.

J Phys Chem B. 2013 Dec 19;117(50):16096-104. doi: 10.1021/jp410216m. Epub 2013 Dec 11.

PMID:
24289143
36.

Feasibility and constraints of particle targeting using the antigen-antibody interaction.

Tokárová V, Pittermannová A, Král V, Řezáčová P, Štěpánek F.

Nanoscale. 2013 Dec 7;5(23):11490-8. doi: 10.1039/c3nr04340a. Epub 2013 Oct 29.

37.

Crystallographic analysis of new psychrophilic haloalkane dehalogenases: DpcA from Psychrobacter cryohalolentis K5 and DmxA from Marinobacter sp. ELB17.

Tratsiak K, Degtjarik O, Drienovska I, Chrast L, Rezacova P, Kuty M, Chaloupkova R, Damborsky J, Kuta Smatanova I.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Jun;69(Pt 6):683-8. doi: 10.1107/S1744309113012979. Epub 2013 May 25.

38.

Differences in crystallization of two LinB variants from Sphingobium japonicum UT26.

Degtjarik O, Chaloupkova R, Rezacova P, Kuty M, Damborsky J, Kuta Smatanova I.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Mar 1;69(Pt 3):284-7. doi: 10.1107/S1744309113002467. Epub 2013 Feb 22.

39.

Engineering enzyme stability and resistance to an organic cosolvent by modification of residues in the access tunnel.

Koudelakova T, Chaloupkova R, Brezovsky J, Prokop Z, Sebestova E, Hesseler M, Khabiri M, Plevaka M, Kulik D, Kuta Smatanova I, Rezacova P, Ettrich R, Bornscheuer UT, Damborsky J.

Angew Chem Int Ed Engl. 2013 Feb 11;52(7):1959-63. doi: 10.1002/anie.201206708. Epub 2013 Jan 9. No abstract available.

PMID:
23303607
40.

Backbone resonance assignments of the outer membrane lipoprotein FrpD from Neisseria meningitidis.

Bumba L, Sviridova E, Kutá Smatanová I, Řezáčová P, Veverka V.

Biomol NMR Assign. 2014 Apr;8(1):53-5. doi: 10.1007/s12104-012-9451-5. Epub 2012 Dec 9.

PMID:
23225222
41.

Structure-aided design of novel inhibitors of HIV protease based on a benzodiazepine scaffold.

Schimer J, Cígler P, Veselý J, Grantz Šašková K, Lepšík M, Brynda J, Rezáčová P, Kožíšek M, Císařová I, Oberwinkler H, Kraeusslich HG, Konvalinka J.

J Med Chem. 2012 Nov 26;55(22):10130-5. doi: 10.1021/jm301249q. Epub 2012 Oct 23.

PMID:
23050738
42.

Mutations in HIV-1 gag and pol compensate for the loss of viral fitness caused by a highly mutated protease.

Kozísek M, Henke S, Sasková KG, Jacobs GB, Schuch A, Buchholz B, Müller V, Kräusslich HG, Rezácová P, Konvalinka J, Bodem J.

Antimicrob Agents Chemother. 2012 Aug;56(8):4320-30. doi: 10.1128/AAC.00465-12. Epub 2012 May 29.

43.

Synthesis, structure-activity relationship studies, and X-ray crystallographic analysis of arylsulfonamides as potent carbonic anhydrase inhibitors.

Gitto R, Damiano FM, Mader P, De Luca L, Ferro S, Supuran CT, Vullo D, Brynda J, Rezáčová P, Chimirri A.

J Med Chem. 2012 Apr 26;55(8):3891-9. doi: 10.1021/jm300112w. Epub 2012 Apr 6.

PMID:
22443141
44.

Structure of the effector-binding domain of the arabinose repressor AraR from Bacillus subtilis.

Procházková K, Cermáková K, Pachl P, Sieglová I, Fábry M, Otwinowski Z, Rezáčová P.

Acta Crystallogr D Biol Crystallogr. 2012 Feb;68(Pt 2):176-85. doi: 10.1107/S090744491105414X. Epub 2012 Jan 17.

45.

The crystal structure of protease Sapp1p from Candida parapsilosis in complex with the HIV protease inhibitor ritonavir.

Dostál J, Brynda J, Hrušková-Heidingsfeldová O, Pachl P, Pichová I, Rezáčová P.

J Enzyme Inhib Med Chem. 2012 Feb;27(1):160-5. doi: 10.3109/14756366.2011.627508. Epub 2011 Dec 6.

PMID:
22146051
46.

Structural basis for inhibition of cathepsin B drug target from the human blood fluke, Schistosoma mansoni.

Jílková A, Rezácová P, Lepsík M, Horn M, Váchová J, Fanfrlík J, Brynda J, McKerrow JH, Caffrey CR, Mares M.

J Biol Chem. 2011 Oct 14;286(41):35770-81. doi: 10.1074/jbc.M111.271304. Epub 2011 Aug 10.

47.

Crystallization and diffraction analysis of thioredoxin reductase from Streptomyces coelicolor.

Koháryová M, Brynda J, Rezáčová P, Kollárová M.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Aug 1;67(Pt 8):917-21. doi: 10.1107/S1744309111021385. Epub 2011 Jul 20.

48.

Crystallization and diffraction analysis of β-N-acetylhexosaminidase from Aspergillus oryzae.

Vaněk O, Brynda J, Hofbauerová K, Kukačka Z, Pachl P, Bezouška K, Rezáčová P.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Apr 1;67(Pt 4):498-503. doi: 10.1107/S1744309111004945. Epub 2011 Mar 26.

49.

Structural basis for the interaction between carbonic anhydrase and 1,2,3,4-tetrahydroisoquinolin-2-ylsulfonamides.

Mader P, Brynda J, Gitto R, Agnello S, Pachl P, Supuran CT, Chimirri A, Řezáčová P.

J Med Chem. 2011 Apr 14;54(7):2522-6. doi: 10.1021/jm2000213. Epub 2011 Mar 11.

PMID:
21395315
50.

Structure of the mouse galectin-4 N-terminal carbohydrate-recognition domain reveals the mechanism of oligosaccharide recognition.

Krejčiříková V, Pachl P, Fábry M, Malý P, Rezáčová P, Brynda J.

Acta Crystallogr D Biol Crystallogr. 2011 Mar;67(Pt 3):204-11. doi: 10.1107/S0907444911004082. Epub 2011 Feb 15.

PMID:
21358051

Supplemental Content

Loading ...
Support Center