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Items: 1 to 50 of 1169

1.

Pochoniolides A and B, new antioxidants from the fungal strain Pochonia chlamydosporia var. spinulospora FKI-7537.

Miyano R, Matsuo H, Nonaka K, Mokudai T, Niwano Y, Shiomi K, Takahashi Y, Ōmura S, Nakashima T.

J Biosci Bioeng. 2018 Jun 22. pii: S1389-1723(18)30288-3. doi: 10.1016/j.jbiosc.2018.05.003. [Epub ahead of print]

PMID:
29941346
2.

Staurosporine: new lease of life for parent compound of today's novel and highly successful anti-cancer drugs.

Ōmura S, Asami Y, Crump A.

J Antibiot (Tokyo). 2018 Jun 22. doi: 10.1038/s41429-018-0029-z. [Epub ahead of print] Review.

PMID:
29934602
3.

Distribution and functional analysis of the phosphopantetheinyl transferase superfamily in Actinomycetales microorganisms.

Kim JH, Komatsu M, Shin-Ya K, Omura S, Ikeda H.

Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):6828-6833. doi: 10.1073/pnas.1800715115. Epub 2018 Jun 14.

4.

Synthesis and insecticidal efficacy of pyripyropene derivatives focusing on the C-1, C-7, and C-11 positions' substituent groups.

Goto K, Horikoshi R, Mitomi M, Oyama K, Hirose T, Sunazuka T, Ōmura S.

J Antibiot (Tokyo). 2018 May 23. doi: 10.1038/s41429-018-0064-9. [Epub ahead of print]

PMID:
29789612
5.

The first horse herders and the impact of early Bronze Age steppe expansions into Asia.

de Barros Damgaard P, Martiniano R, Kamm J, Moreno-Mayar JV, Kroonen G, Peyrot M, Barjamovic G, Rasmussen S, Zacho C, Baimukhanov N, Zaibert V, Merz V, Biddanda A, Merz I, Loman V, Evdokimov V, Usmanova E, Hemphill B, Seguin-Orlando A, Yediay FE, Ullah I, Sjögren KG, Iversen KH, Choin J, de la Fuente C, Ilardo M, Schroeder H, Moiseyev V, Gromov A, Polyakov A, Omura S, Senyurt SY, Ahmad H, McKenzie C, Margaryan A, Hameed A, Samad A, Gul N, Khokhar MH, Goriunova OI, Bazaliiskii VI, Novembre J, Weber AW, Orlando L, Allentoft ME, Nielsen R, Kristiansen K, Sikora M, Outram AK, Durbin R, Willerslev E.

Science. 2018 Jun 29;360(6396). pii: eaar7711. doi: 10.1126/science.aar7711. Epub 2018 May 9.

PMID:
29743352
6.

New metabolites, sarcopodinols A and B, isolated from deep-sea derived fungal strain Sarcopodium sp. FKJ-0025.

Matsuo H, Nonaka K, Nagano Y, Yabuki A, Fujikura K, Takahashi Y, Ōmura S, Nakashima T.

Biosci Biotechnol Biochem. 2018 Aug;82(8):1323-1326. doi: 10.1080/09168451.2018.1467264. Epub 2018 Apr 26.

PMID:
29699461
7.

Hamuramicins A and B, 22-membered macrolides, produced by an endophytic actinomycete Allostreptomyces sp. K12-0794.

Suga T, Kimura T, Inahashi Y, Iwatsuki M, Nonaka K, Také A, Matsumoto A, Takahashi Y, Ōmura S, Nakashima T.

J Antibiot (Tokyo). 2018 Jul;71(7):619-625. doi: 10.1038/s41429-018-0055-x. Epub 2018 Apr 24.

PMID:
29691484
8.

Quellenin, a new anti-Saprolegnia compound isolated from the deep-sea fungus, Aspergillus sp. YK-76.

Takahashi K, Sakai K, Fukasawa W, Nagano Y, Sakaguchi SO, Lima AO, Pellizari VH, Iwatsuki M, Takishita K, Yoshida T, Nonaka K, Fujikura K, Ōmura S.

J Antibiot (Tokyo). 2018 Apr 23. doi: 10.1038/s41429-018-0053-z. [Epub ahead of print]

PMID:
29686353
9.

Identification and heterologous expression of the actinoallolide biosynthetic gene cluster.

Inahashi Y, Shiraishi T, Také A, Matsumoto A, Takahashi Y, Ōmura S, Kuzuyama T, Nakashima T.

J Antibiot (Tokyo). 2018 Apr 20. doi: 10.1038/s41429-018-0057-8. [Epub ahead of print]

PMID:
29679043
10.

Streptomyces boninensis sp. nov., isolated from soil from a limestone cave in the Ogasawara Islands.

Také A, Inahashi Y, Ōmura S, Takahashi Y, Matsumoto A.

Int J Syst Evol Microbiol. 2018 May;68(5):1795-1799. doi: 10.1099/ijsem.0.002753. Epub 2018 Apr 6.

PMID:
29624162
11.

Tolyprolinol, a new dipeptide from Tolypocladium sp. FKI-7981.

Fukasawa W, Mori N, Iwatsuki M, Hokari R, Ishiyama A, Nakajima M, Ouchi T, Nonaka K, Kojima H, Matsuo H, Ōmura S, Shiomi K.

J Antibiot (Tokyo). 2018 Jul;71(7):682-684. doi: 10.1038/s41429-018-0041-3. Epub 2018 Mar 22.

PMID:
29563600
12.

Oxoberkedienoic acid: a new octadienoic acid derivative isolated from Talaromyces verruculosus using a chemical screening system.

Sakai K, Asami Y, Chiba T, Suga T, Nonaka K, Iwatsuki M, Ōmura S, Shiomi K.

J Gen Appl Microbiol. 2018 Mar 19. doi: 10.2323/jgam.2017.09.001. [Epub ahead of print] No abstract available.

13.

Pyrizomicin A and B: structure and bioactivity of new thiazolyl pyridines from Lechevalieria aerocolonigenes K10-0216.

Kimura T, Inahashi Y, Matsuo H, Suga T, Iwatsuki M, Shiomi K, Takahashi Y, Ōmura S, Nakashima T.

J Antibiot (Tokyo). 2018 Jun;71(6):606-608. doi: 10.1038/s41429-018-0038-y. Epub 2018 Mar 7.

PMID:
29515230
14.

Dipyrimicin A and B, microbial compounds isolated from Amycolatopsis sp. K16-0194.

Izuta S, Kosaka S, Kawai M, Miyano R, Matsuo H, Matsumoto A, Nonaka K, Takahashi Y, Ōmura S, Nakashima T.

J Antibiot (Tokyo). 2018 May;71(5):535-537. doi: 10.1038/s41429-018-0028-0. Epub 2018 Feb 20.

PMID:
29463887
15.

Orthognathic Surgery and Implant-Supported Bridge in a Class III Patient Injured in a Motor Vehicle Accident.

Honda K, Hirota M, Iwai T, Fujita K, Omura S, Ono T, Tohnai I.

J Craniofac Surg. 2018 May;29(3):e296-e298. doi: 10.1097/SCS.0000000000004339.

PMID:
29420385
16.

Mumiamicin: Structure and bioactivity of a new furan fatty acid from Mumia sp. YSP-2-79.

Kimura T, Tajima A, Inahashi Y, Iwatsuki M, Kasai H, Mokudai T, Niwano Y, Shiomi K, Takahashi Y, Ōmura S, Nakashima T.

J Gen Appl Microbiol. 2018 May 21;64(2):62-67. doi: 10.2323/jgam.2017.06.004. Epub 2018 Jan 25.

17.

Immunoregulation of Theiler's virus-induced demyelinating disease by glatiramer acetate without suppression of antiviral immune responses.

Omura S, Sato F, Martinez NE, Range T, Ekshyyan L, Minagar A, Alexander JS, Tsunoda I.

Arch Virol. 2018 May;163(5):1279-1284. doi: 10.1007/s00705-018-3729-6. Epub 2018 Jan 23.

PMID:
29362931
18.

Jietacins, azoxy antibiotics with potent nematocidal activity: Design, synthesis, and biological evaluation against parasitic nematodes.

Sugawara A, Kubo M, Hirose T, Yahagi K, Tsunoda N, Noguchi Y, Nakashima T, Takahashi Y, Welz C, Mueller D, Mertens C, Koebberling J, Ōmura S, Sunazuka T.

Eur J Med Chem. 2018 Feb 10;145:524-538. doi: 10.1016/j.ejmech.2017.12.031. Epub 2017 Dec 28.

PMID:
29335213
19.

Design and Synthesis of A-Ring Simplified Pyripyropene A Analogues as Potent and Selective Synthetic SOAT2 Inhibitors.

Ohtawa M, Arima S, Ichida N, Terayama T, Ohno H, Yamazaki T, Ohshiro T, Sato N, Omura S, Tomoda H, Nagamitsu T.

ChemMedChem. 2018 Mar 6;13(5):411-421. doi: 10.1002/cmdc.201700645. Epub 2018 Jan 30.

PMID:
29323466
20.

Design, synthesis and anti-malarial activities of synthetic analogs of biselyngbyolide B, a Ca2+ pump inhibitor from marine cyanobacteria.

Sato E, Morita M, Ogawa H, Iwatsuki M, Hokari R, Ishiyama A, Ōmura S, Iwasaki A, Suenaga K.

Bioorg Med Chem Lett. 2017 Dec 24. pii: S0960-894X(17)31224-6. doi: 10.1016/j.bmcl.2017.12.050. [Epub ahead of print]

PMID:
29292225
21.

Metallothionein I as a direct link between therapeutic hematopoietic stem/progenitor cells and cerebral protection in stroke.

Smith HK, Omura S, Vital SA, Becker F, Senchenkova EY, Kaur G, Tsunoda I, Peirce SM, Gavins FNE.

FASEB J. 2018 May;32(5):2381-2394. doi: 10.1096/fj.201700746R. Epub 2017 Dec 21.

PMID:
29269399
22.

Helicobacter pylori and gut microbiota in multiple sclerosis versus Alzheimer's disease: 10 pitfalls of microbiome studies.

Park AM, Omura S, Fujita M, Sato F, Tsunoda I.

Clin Exp Neuroimmunol. 2017 Aug;8(3):215-232. doi: 10.1111/cen3.12401. Epub 2017 Jul 23.

PMID:
29158778
23.

Chemotherapeutic efficacies of a clofazimine and diminazene aceturate combination against piroplasm parasites and their AT-rich DNA-binding activity on Babesia bovis.

Tuvshintulga B, AbouLaila M, Sivakumar T, Tayebwa DS, Gantuya S, Naranbaatar K, Ishiyama A, Iwatsuki M, Otoguro K, Ōmura S, Terkawi MA, Guswanto A, Rizk MA, Yokoyama N, Igarashi I.

Sci Rep. 2017 Oct 24;7(1):13888. doi: 10.1038/s41598-017-14304-0.

24.

Beauvericin counteracted multi-drug resistant Candida albicans by blocking ABC transporters.

Tong Y, Liu M, Zhang Y, Liu X, Huang R, Song F, Dai H, Ren B, Sun N, Pei G, Bian J, Jia XM, Huang G, Zhou X, Li S, Zhang B, Fukuda T, Tomoda H, Ōmura S, Cannon RD, Calderone R, Zhang L.

Synth Syst Biotechnol. 2016 Oct 25;1(3):158-168. doi: 10.1016/j.synbio.2016.10.001. eCollection 2016 Sep.

25.

Ascosteroside D, a new mitochondrial respiration inhibitor discovered by pesticidal screening using insect ADP/ATP carrier protein-expressing Saccharomyces cerevisiae.

Watanabe Y, Asami Y, Narusawa S, Hashimoto S, Iwatsuki M, Nonaka K, Shinohara Y, Shiotsuki T, Ichimaru N, Miyoshi H, Ōmura S, Shiomi K.

J Antibiot (Tokyo). 2017 Oct 11. doi: 10.1038/ja.2017.118. [Epub ahead of print]

PMID:
29018265
26.

Bisoxazolomycin A: a new natural product from 'Streptomyces subflavus subsp. irumaensis' AM-3603.

Koomsiri W, Inahashi Y, Kimura T, Shiomi K, Takahashi Y, Ōmura S, Thamchaipenet A, Nakashima T.

J Antibiot (Tokyo). 2017 Dec;70(12):1142-1145. doi: 10.1038/ja.2017.113. Epub 2017 Sep 27.

PMID:
28951599
27.

Saccharomonospora colocasiae sp. nov., an actinomycete isolated from the rhizosphere of Colocasia esculenta.

Wattanasuepsin W, Intra B, Také A, Inahashi Y, Euanorasetr J, Ōmura S, Matsumoto A, Panbangred W.

Int J Syst Evol Microbiol. 2017 Nov;67(11):4572-4577. doi: 10.1099/ijsem.0.002336. Epub 2017 Sep 25.

PMID:
28945543
28.

T-bet, but not Gata3, overexpression is detrimental in a neurotropic viral infection.

Sato F, Kawai E, Martinez NE, Omura S, Park AM, Takahashi S, Yoh K, Tsunoda I.

Sci Rep. 2017 Sep 5;7(1):10496. doi: 10.1038/s41598-017-10980-0.

29.

Corrigendum: γ-Ionylidene-type sesquiterpenoids possessing antimicrobial activity against Porphyromonas gingivalis from Phellinus linteus and their absolute structure determination.

Shirahata T, Ino C, Mizuno F, Asada Y, Hirotani M, Petersson GA, Ōmura S, Yoshikawa T, Kobayashi Y.

J Antibiot (Tokyo). 2017 Aug;70(9):979. doi: 10.1038/ja.2017.71.

PMID:
28845046
30.

Antimalarial troponoids, puberulic acid and viticolins; divergent synthesis and structure-activity relationship studies.

Sennari G, Saito R, Hirose T, Iwatsuki M, Ishiyama A, Hokari R, Otoguro K, Ōmura S, Sunazuka T.

Sci Rep. 2017 Aug 3;7(1):7259. doi: 10.1038/s41598-017-07718-3.

31.

Corrigendum: Iminimycin A, the new iminium metabolite produced by Streptomyces griseus OS-3601.

Nakashima T, Miyano R, Iwatsuki M, Shirahata T, Kimura T, Asami Y, Kobayashi Y, Shiomi K, Petersson GA, Takahashi Y, Ōmura S.

J Antibiot (Tokyo). 2017 Jul;70(8):921. doi: 10.1038/ja.2017.68.

PMID:
28747796
32.

Toward the total synthesis of luminamicin; an anaerobic antibiotic: construction of highly functionalized cis-decalin containing a bridged ether moiety.

Ando H, Kimishima A, Ohara M, Hirose T, Matsumaru T, Takada H, Morodome K, Miyamoto T, Sugawara A, Ōmura S, Sunazuka T.

J Antibiot (Tokyo). 2018 Feb;71(2):268-272. doi: 10.1038/ja.2017.77. Epub 2017 Jul 5.

PMID:
28676718
33.

Three immune-mediated disease models induced by Theiler's virus: Multiple sclerosis, seizures and myocarditis.

Tsunoda I, Sato F, Omura S, Fujita M, Sakiyama N, Park AM.

Clin Exp Neuroimmunol. 2016 Nov;7(4):330-345. doi: 10.1111/cen3.12341. Epub 2016 Oct 25.

34.

Three novel species of the genus Kibdelosporangium; Kibdelosporangium kanagawaense sp. nov., Kibdelosporangiumrhizosphaerae sp. nov. and Kibdelosporangium rhizovicinum sp. nov.

Mingma R, Duangmal K, Ōmura S, Takahashi Y, Matsumoto A.

Int J Syst Evol Microbiol. 2017 Jun;67(6):1758-1765. doi: 10.1099/ijsem.0.001861. Epub 2017 Jun 9.

PMID:
28598312
35.

Cladomarine, a new anti-saprolegniasis compound isolated from the deep-sea fungus, Penicillium coralligerum YK-247.

Takahashi K, Sakai K, Nagano Y, Orui Sakaguchi S, Lima AO, Pellizari VH, Iwatsuki M, Takishita K, Nonaka K, Fujikura K, Ōmura S.

J Antibiot (Tokyo). 2017 Jul;70(8):911-914. doi: 10.1038/ja.2017.58. Epub 2017 May 31. No abstract available.

PMID:
28559580
36.

5-O-Mycaminosyltylonolide antibacterial derivatives: design, synthesis and bioactivity.

Sugawara A, Maruyama H, Shibusawa S, Matsui H, Hirose T, Tsutsui A, Froyman R, Ludwig C, Koebberling J, Hanaki H, Kleefeld G, Ōmura S, Sunazuka T.

J Antibiot (Tokyo). 2017 Jul;70(8):878-887. doi: 10.1038/ja.2017.61. Epub 2017 May 31.

PMID:
28559578
37.

Ivermectin and malaria control.

Ōmura S, Crump A.

Malar J. 2017 Apr 24;16(1):172. doi: 10.1186/s12936-017-1825-9.

38.

Computational fluid dynamics study of the pharyngeal airway space before and after mandibular setback surgery in patients with mandibular prognathism.

Yajima Y, Oshima M, Iwai T, Kitajima H, Omura S, Tohnai I.

Int J Oral Maxillofac Surg. 2017 Jul;46(7):839-844. doi: 10.1016/j.ijom.2017.03.028. Epub 2017 Apr 12.

PMID:
28412180
39.

γ-Ionylidene-type sesquiterpenoids possessing antimicrobial activity against Porphyromonas gingivalis from Phellinus linteus and their absolute structure determination.

Shirahata T, Ino C, Mizuno F, Asada Y, Hirotani M, Petersson GA, Ōmura S, Yoshikawa T, Kobayashi Y.

J Antibiot (Tokyo). 2017 May;70(5):695-698. doi: 10.1038/ja.2017.35. Epub 2017 Mar 22. No abstract available. Erratum in: J Antibiot (Tokyo). 2017 Aug;70(9):979.

PMID:
28325930
40.

Naphthacemycins, novel circumventors of β-lactam resistance in MRSA, produced by Streptomyces sp. KB-3346-5. I. The taxonomy of the producing strain, and the fermentation, isolation and antibacterial activities.

Fukumoto A, Kim YP, Matsumoto A, Takahashi Y, Suzuki M, Onodera H, Tomoda H, Matsui H, Hanaki H, Iwatsuki M, Ōmura S, Shiomi K.

J Antibiot (Tokyo). 2017 May;70(5):562-567. doi: 10.1038/ja.2017.28. Epub 2017 Mar 15.

PMID:
28293038
41.

Naphthacemycins, novel circumventors of β-lactam resistance in MRSA, produced by Streptomyces sp. KB-3346-5. II. Structure elucidation.

Fukumoto A, Kim YP, Iwatsuki M, Hirose T, Sunazuka T, Hanaki H, Ōmura S, Shiomi K.

J Antibiot (Tokyo). 2017 May;70(5):568-573. doi: 10.1038/ja.2017.29. Epub 2017 Mar 15.

PMID:
28293036
42.

Ivermectin efficacy against Biomphalaria, intermediate host snail vectors of Schistosomiasis.

Katz N, Araújo N, Coelho PMZ, Morel CM, Linde-Arias AR, Yamada T, Horimatsu Y, Suzuki K, Sunazuka T, Ōmura S.

J Antibiot (Tokyo). 2017 May;70(5):680-684. doi: 10.1038/ja.2017.31. Epub 2017 Mar 15.

PMID:
28293033
43.

Development of a new air-stable structure-simplified nafuredin-γ analog as a potent and selective nematode complex I inhibitor.

Ohtawa M, Arima S, Shimizu R, Hanatani N, Shimizu E, Shiomi K, Kita K, Ōmura S, Nagamitsu T.

J Antibiot (Tokyo). 2017 May;70(5):647-654. doi: 10.1038/ja.2017.16. Epub 2017 Feb 22.

PMID:
28223689
44.

Nanaomycin H: A new nanaomycin analog.

Nakashima T, Kimura T, Miyano R, Matsuo H, Hirose T, Kimishima A, Nonaka K, Iwatsuki M, Nakanishi J, Takahashi Y, Ōmura S.

J Biosci Bioeng. 2017 Jun;123(6):765-770. doi: 10.1016/j.jbiosc.2017.01.011. Epub 2017 Feb 13.

PMID:
28202308
45.

Decatamariic acid, a new mitochondrial respiration inhibitor discovered by pesticidal screening using drug-sensitive Saccharomyces cerevisiae.

Watanabe Y, Suga T, Narusawa S, Iwatsuki M, Nonaka K, Nakashima T, Shinohara Y, Shiotsuki T, Ichimaru N, Miyoshi H, Asami Y, Ōmura S, Shiomi K.

J Antibiot (Tokyo). 2017 Apr;70(4):395-399. doi: 10.1038/ja.2016.164. Epub 2017 Jan 18.

PMID:
28096549
46.

Identification of pyripyropene A as a promising insecticidal compound in a microbial metabolite screening.

Horikoshi R, Goto K, Mitomi M, Oyama K, Sunazuka T, Ōmura S.

J Antibiot (Tokyo). 2017 Mar;70(3):272-276. doi: 10.1038/ja.2016.155. Epub 2017 Jan 11.

PMID:
28074053
47.

Corrigendum: Streptomyces lactacystinicus sp. nov. and Streptomyces cyslabdanicus sp. nov., producing lactacystin and cyslabdan, respectively.

Také A, Matsumoto A, Ōmura S, Takahashi Y.

J Antibiot (Tokyo). 2017 Jan;70(1):113. doi: 10.1038/ja.2016.103. No abstract available.

PMID:
28053352
48.

Total synthesis of (±)-naphthacemycin A9, possessing both antibacterial activity against methicillin-resistant Staphylococcus aureus and circumventing effect of β-lactam resistance.

Hirose T, Kojima Y, Matsui H, Hanaki H, Iwatsuki M, Shiomi K, Ōmura S, Sunazuka T.

J Antibiot (Tokyo). 2017 May;70(5):574-581. doi: 10.1038/ja.2016.141. Epub 2016 Dec 7.

PMID:
27924114
49.

The Design, Synthesis, and Evaluation of 1,5,7-Trisubstituted-3-Pyridyl-Xanthones for Use as Insecticides Starting from Pyripyropene A.

Fuse S, Matsumura K, Johmoto K, Uekusa H, Tanaka H, Hirose T, Sunazuka T, Ōmura S, Takahashi T.

Chemistry. 2016 Dec 19;22(51):18450-18455. doi: 10.1002/chem.201603980. Epub 2016 Nov 9.

PMID:
27862416
50.

Computational Fluid Dynamic Study of Nasal Respiratory Function Before and After Bimaxillary Orthognathic Surgery With Bone Trimming at the Inferior Edge of the Pyriform Aperture.

Kita S, Oshima M, Shimazaki K, Iwai T, Omura S, Ono T.

J Oral Maxillofac Surg. 2016 Nov;74(11):2241-2251. doi: 10.1016/j.joms.2016.06.171. Epub 2016 Jun 21.

PMID:
27425883

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