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Extremely poor patient-reported outcomes are associated with lack of clinical response and decreased retention rate of tumour necrosis factor inhibitor treatment in patients with axial spondyloarthritis.

Krabbe S, Glintborg B, Østergaard M, Hetland ML.

Scand J Rheumatol. 2018 Aug 13:1-5. doi: 10.1080/03009742.2018.1481225. [Epub ahead of print]


Anti-cyclic citrullinated peptide antibodies, 28-joint Disease Activity Score, and magnetic resonance imaging bone oedema at baseline predict 11 years' functional and radiographic outcome in early rheumatoid arthritis.

Hetland ML, Østergaard M, Stengaard-Pedersen K, Junker P, Ejbjerg B, Jacobsen S, Ellingsen T, Lindegaard H, Pødenphant J, Vestergaard A, Jurik AG, Krogh NS, Hørslev-Petersen K; and The CIMESTRA Study Group*.

Scand J Rheumatol. 2018 Aug 13:1-8. doi: 10.1080/03009742.2018.1466362. [Epub ahead of print]


Prevalence of Psoriasis and Psoriatic Arthritis and Patient Perceptions of Severity in Sweden, Norway and Denmark: Results from the Nordic Patient Survey of Psoriasis and Psoriatic Arthritis.

Danielsen K, Duvetorp A, Iversen L, Østergaard M, Seifert O, Steinar Tveit K, Skov L.

Acta Derm Venereol. 2018 Aug 7. doi: 10.2340/00015555-3017. [Epub ahead of print]


Structural damage progression in patients with early rheumatoid arthritis treated with methotrexate, baricitinib, or baricitinib plus methotrexate based on clinical response in the phase 3 RA-BEGIN study.

van der Heijde D, Durez P, Schett G, Naredo E, Østergaard M, Meszaros G, De Leonardis F, de la Torre I, López-Romero P, Schlichting D, Nantz E, Fleischmann R.

Clin Rheumatol. 2018 Sep;37(9):2381-2390. doi: 10.1007/s10067-018-4221-0. Epub 2018 Aug 4.


The D-vitamin metabolite 1,25(OH)2D in serum is associated with disease activity and Anti-Citrullinated Protein Antibodies in active and treatment naïve, early Rheumatoid Arthritis Patients.

Herly M, Stengaard-Pedersen K, Vestergaard P, Østergaard M, Junker P, Hetland ML, Hørslev-Petersen K, Ellingsen T.

Scand J Immunol. 2018 Jul 20:e12704. doi: 10.1111/sji.12704. [Epub ahead of print]


Studies directed toward the asialoglycoprotein receptor mediated delivery of 5-fluoro-2'-deoxyuridine for hepatocellular carcinoma.

Rico L, Østergaard ME, Bell M, Seth PP, Hanessian S.

Bioorg Med Chem Lett. 2018 Aug 15;28(15):2652-2654. doi: 10.1016/j.bmcl.2018.06.002. Epub 2018 Jun 1.


Predictive value of a multi-biomarker disease activity score for clinical remission and radiographic progression in patients with early rheumatoid arthritis: a post-hoc study of the OPERA trial.

Brahe CH, Østergaard M, Johansen JS, Defranoux N, Wang X, Bolce R, Sasso EH, Ørnbjerg LM, Hørslev-Petersen K, Stengaard-Pedersen K, Junker P, Ellingsen T, Ahlquist P, Lindegaard H, Linauskas A, Schlemmer A, Dam MY, Hansen I, Lottenburger T, Ammitzbøll C, Jørgensen A, Krintel SB, Raun J, Hetland ML.

Scand J Rheumatol. 2018 Jul 9:1-8. doi: 10.1080/03009742.2018.1464206. [Epub ahead of print]


Author Correction: Recurrent lower respiratory illnesses among young children in rural Kyrgyzstan: overuse of antibiotics and possible under-diagnosis of asthma. A qualitative FRESH AIR study.

Østergaard MS, Kjærgaard J, Kristensen MM, Reventlow S, Poulsen A, Isaeva E, Akylbekov A, Sooronbaev T.

NPJ Prim Care Respir Med. 2018 Jun 28;28(1):25. doi: 10.1038/s41533-018-0082-x.


Risankizumab, an IL-23 inhibitor, for ankylosing spondylitis: results of a randomised, double-blind, placebo-controlled, proof-of-concept, dose-finding phase 2 study.

Baeten D, Østergaard M, Wei JC, Sieper J, Järvinen P, Tam LS, Salvarani C, Kim TH, Solinger A, Datsenko Y, Pamulapati C, Visvanathan S, Hall DB, Aslanyan S, Scholl P, Padula SJ.

Ann Rheum Dis. 2018 Sep;77(9):1295-1302. doi: 10.1136/annrheumdis-2018-213328. Epub 2018 Jun 26.


Options for Assessing Joints and Entheses in Psoriatic Arthritis by Ultrasonography and Magnetic Resonance Imaging: How to Move Forward.

Eder L, Aydin SZ, Kaeley GS, Maksymowych WP, Østergaard M.

J Rheumatol Suppl. 2018 Jun;94:44-47. doi: 10.3899/jrheum.180140.


Standardised assessment of competence in Focused Assessment with Sonography for Trauma.

Russell L, Østergaard ML, Nielsen MB, Konge L, Nielsen KR.

Acta Anaesthesiol Scand. 2018 Apr 30. doi: 10.1111/aas.13141. [Epub ahead of print]


Recurrent lower respiratory illnesses among young children in rural Kyrgyzstan: overuse of antibiotics and possible under-diagnosis of asthma. A qualitative FRESH AIR study.

Østergaard MS, Kjærgaard J, Kristensen MM, Reventlow S, Poulsen A, Isaeva E, Akylbekov A, Sooronbaev T.

NPJ Prim Care Respir Med. 2018 Apr 10;28(1):13. doi: 10.1038/s41533-018-0081-y. Erratum in: NPJ Prim Care Respir Med. 2018 Jun 28;28(1):25.


Inflammatory and structural changes in vertebral bodies and posterior elements of the spine in axial spondyloarthritis: construct validity, responsiveness and discriminatory ability of the anatomy-based CANDEN scoring system in a randomised placebo-controlled trial.

Krabbe S, Sørensen IJ, Jensen B, Møller JM, Balding L, Madsen OR, Lambert RGW, Maksymowych WP, Pedersen SJ, Østergaard M.

RMD Open. 2018 Mar 16;4(1):e000624. doi: 10.1136/rmdopen-2017-000624. eCollection 2018.


Atlas for the OMERACT thumb base osteoarthritis MRI scoring system (TOMS).

Kroon FPB, Peterfy CG, Conaghan PG, Foltz V, Gandjbakhch F, Eshed I, Genant HK, Østergaard M, Reijnierse M, Bloem JL, Haugen IK, Kloppenburg M.

RMD Open. 2018 Feb 8;4(1):e000583. doi: 10.1136/rmdopen-2017-000583. eCollection 2018. Review. Erratum in: RMD Open. 2018 Apr 25;4(1):e000583corr1.


Whole-body Magnetic Resonance Imaging in Axial Spondyloarthritis: Reduction of Sacroiliac, Spinal, and Entheseal Inflammation in a Placebo-controlled Trial of Adalimumab.

Krabbe S, Østergaard M, Eshed I, Sørensen IJ, Jensen B, Møller JM, Balding L, Madsen OR, Asmussen K, Eng G, Jørgensen NR, Pedersen SJ.

J Rheumatol. 2018 May;45(5):621-629. doi: 10.3899/jrheum.170408. Epub 2018 Feb 15.


Glycoconjugate Oxime Formation Catalyzed at Neutral pH: Mechanistic Insights and Applications of 1,4-Diaminobenzene as a Superior Catalyst for Complex Carbohydrates.

Østergaard M, Christensen NJ, Hjuler CT, Jensen KJ, Thygesen MB.

Bioconjug Chem. 2018 Apr 18;29(4):1219-1230. doi: 10.1021/acs.bioconjchem.8b00019. Epub 2018 Feb 27.


Circulating serum interleukin-6, serum chitinase-3-like protein-1, and plasma vascular endothelial growth factor are not predictive for remission and radiographic progression in patients with early rheumatoid arthritis: post-hoc explorative and validation studies based on the CIMESTRA and OPERA trials.

Brahe CH, Dehlendorff C, Østergaard M, Johansen JS, Ørnbjerg LM, Hørslev-Petersen K, Stengaard-Pedersen K, Junker P, Ellingsen T, Lindegaard H, Hansen I, Lottenburger T, Jacobsen S, Jurik AG, Hetland ML.

Scand J Rheumatol. 2018 Jul;47(4):259-269. doi: 10.1080/03009742.2017.1376107. Epub 2018 Jan 16.


The Use of the OMERACT Ultrasound Tenosynovitis Scoring System in Multicenter Clinical Trials.

Ammitzbøll-Danielsen M, Østergaard M, Naredo E, Iagnocco A, Möller I, D'Agostino MA, Gandjbakhch F, Terslev L.

J Rheumatol. 2018 Feb;45(2):165-169. doi: 10.3899/jrheum.170501. Epub 2017 Dec 15.


The effect of an intensive smoking cessation intervention on disease activity in patients with rheumatoid arthritis: study protocol for a randomised controlled trial.

Roelsgaard IK, Thomsen T, Østergaard M, Christensen R, Hetland ML, Jacobsen S, Andersen L, Tønnesen H, Rollefstad S, Semb AG, Esbensen BA.

Trials. 2017 Nov 28;18(1):570. doi: 10.1186/s13063-017-2309-5.


Minimal Disease Activity as a Treatment Target in Psoriatic Arthritis: A Review of the Literature.

Gossec L, McGonagle D, Korotaeva T, Lubrano E, de Miguel E, Østergaard M, Behrens F.

J Rheumatol. 2018 Jan;45(1):6-13. doi: 10.3899/jrheum.170449. Epub 2017 Nov 15. Review.


Plasma MicroRNA Profiles in Patients with Early Rheumatoid Arthritis Responding to Adalimumab plus Methotrexate vs Methotrexate Alone: A Placebo-controlled Clinical Trial.

Sode J, Krintel SB, Carlsen AL, Hetland ML, Johansen JS, Hørslev-Petersen K, Stengaard-Pedersen K, Ellingsen T, Burton M, Junker P, Østergaard M, Heegaard NHH.

J Rheumatol. 2018 Jan;45(1):53-61. doi: 10.3899/jrheum.170266. Epub 2017 Nov 15.


Test-Retest Reliability of an Experienced Global Trigger Tool Review Team.

Bjørn B, Anhøj J, Østergaard M, Kodal AM, von Plessen C.

J Patient Saf. 2017 Oct 12. doi: 10.1097/PTS.0000000000000433. [Epub ahead of print]


Galectin-3 is Persistently Increased in Early Rheumatoid Arthritis (RA) and Associates with Anti-CCP Seropositivity and MRI Bone Lesions, While Early Fibrosis Markers Correlate with Disease Activity.

Issa SF, Christensen AF, Lindegaard HM, Hetland ML, Hørslev-Petersen K, Stengaard-Pedersen K, Ejbjerg BJ, Lottenburger T, Ellingsen T, Pedersen JK, Junker K, Svendsen A, Tarp U, Østergaard M, Junker P.

Scand J Immunol. 2017 Dec;86(6):471-478. doi: 10.1111/sji.12619. Epub 2017 Nov 1.


Development and Validation of MRI Sacroiliac Joint Scoring Methods for the Semiaxial Scan Plane Corresponding to the Berlin and SPARCC MRI Scoring Methods, and of a New Global MRI Sacroiliac Joint Method.

Hededal P, Østergaard M, Sørensen IJ, Loft AG, Hindrup JS, Thamsborg G, Asmussen K, Hendricks O, Nørregaard J, Møller JM, Jurik AG, Morsel L, Balding L, Pedersen SJ.

J Rheumatol. 2018 Jan;45(1):70-77. doi: 10.3899/jrheum.161583. Epub 2017 Oct 1.


Prolonged exposure of mouse and human podocytes to insulin induces insulin resistance through lysosomal and proteasomal degradation of the insulin receptor.

Lay AC, Hurcombe JA, Betin VMS, Barrington F, Rollason R, Ni L, Gillam L, Pearson GME, Østergaard MV, Hamidi H, Lennon R, Welsh GI, Coward RJM.

Diabetologia. 2017 Nov;60(11):2299-2311. doi: 10.1007/s00125-017-4394-0. Epub 2017 Aug 29.


The OMERACT Rheumatoid Arthritis Magnetic Resonance Imaging (MRI) Scoring System: Updated Recommendations by the OMERACT MRI in Arthritis Working Group.

Østergaard M, Peterfy CG, Bird P, Gandjbakhch F, Glinatsi D, Eshed I, Haavardsholm EA, Lillegraven S, Bøyesen P, Ejbjerg B, Foltz V, Emery P, Genant HK, Conaghan PG.

J Rheumatol. 2017 Nov;44(11):1706-1712. doi: 10.3899/jrheum.161433. Epub 2017 Aug 15.


What the Rheumatologist Is Looking for and What the Radiologist Should Know in Imaging for Rheumatoid Arthritis.

Teh J, Østergaard M.

Radiol Clin North Am. 2017 Sep;55(5):905-916. doi: 10.1016/j.rcl.2017.04.001. Epub 2017 Jun 12. Review.


Development of a reliable simulation-based test for diagnostic abdominal ultrasound with a pass/fail standard usable for mastery learning.

Østergaard ML, Nielsen KR, Albrecht-Beste E, Konge L, Nielsen MB.

Eur Radiol. 2018 Jan;28(1):51-57. doi: 10.1007/s00330-017-4913-x. Epub 2017 Jul 4.


Web-Based Alcohol Intervention: Study of Systematic Attrition of Heavy Drinkers.

Radtke T, Ostergaard M, Cooke R, Scholz U.

J Med Internet Res. 2017 Jun 28;19(6):e217. doi: 10.2196/jmir.6780.


Fluorinated Nucleotide Modifications Modulate Allele Selectivity of SNP-Targeting Antisense Oligonucleotides.

Østergaard ME, Nichols J, Dwight TA, Lima W, Jung ME, Swayze EE, Seth PP.

Mol Ther Nucleic Acids. 2017 Jun 16;7:20-30. doi: 10.1016/j.omtn.2017.02.001. Epub 2017 Feb 9.


Whole-body Magnetic Resonance Imaging in Inflammatory Arthritis: Systematic Literature Review and First Steps Toward Standardization and an OMERACT Scoring System.

Østergaard M, Eshed I, Althoff CE, Poggenborg RP, Diekhoff T, Krabbe S, Weckbach S, Lambert RGW, Pedersen SJ, Maksymowych WP, Peterfy CG, Freeston J, Bird P, Conaghan PG, Hermann KG.

J Rheumatol. 2017 Nov;44(11):1699-1705. doi: 10.3899/jrheum.161114. Epub 2017 Jun 15. Review.


Magnetic resonance imaging assessed inflammation in the wrist is associated with patient-reported physical impairment, global assessment of disease activity and pain in early rheumatoid arthritis: longitudinal results from two randomised controlled trials.

Glinatsi D, Baker JF, Hetland ML, Hørslev-Petersen K, Ejbjerg BJ, Stengaard-Pedersen K, Junker P, Ellingsen T, Lindegaard HM, Hansen I, Lottenburger T, Møller JM, Ørnbjerg L, Vestergaard A, Jurik AG, Thomsen HS, Torfing T, Møller-Bisgaard S, Axelsen MB, Østergaard M.

Ann Rheum Dis. 2017 Oct;76(10):1707-1715. doi: 10.1136/annrheumdis-2017-211315. Epub 2017 Jun 13.


Obesity and rates of clinical remission and low MRI inflammation in rheumatoid arthritis.

George MD, Østergaard M, Conaghan PG, Emery P, Baker DG, Baker JF.

Ann Rheum Dis. 2017 Oct;76(10):1743-1746. doi: 10.1136/annrheumdis-2017-211569. Epub 2017 Jun 12.


Soluble CD206 plasma levels in rheumatoid arthritis reflect decrease in disease activity.

Heftdal LD, Stengaard-Pedersen K, Ørnbjerg LM, Hetland ML, Hørslev-Petersen K, Junker P, Østergaard M, Hvid M, Deleuran B, Møller HJ, Greisen SR.

Scand J Clin Lab Invest. 2017 Sep;77(5):385-389. doi: 10.1080/00365513.2017.1331462. Epub 2017 Jun 9.


The efficacy of motivational counselling and SMS reminders on daily sitting time in patients with rheumatoid arthritis: a randomised controlled trial.

Thomsen T, Aadahl M, Beyer N, Hetland ML, Løppenthin K, Midtgaard J, Christensen R, Østergaard M, Jennum PJ, Esbensen BA.

Ann Rheum Dis. 2017 Sep;76(9):1603-1606. doi: 10.1136/annrheumdis-2016-210953. Epub 2017 Jun 5.


Analysis of risk factors for infant mortality in the 1992-3 and 2002-3 birth cohorts in rural Guinea-Bissau.

Byberg S, Østergaard MD, Rodrigues A, Martins C, Benn CS, Aaby P, Fisker AB.

PLoS One. 2017 May 18;12(5):e0177984. doi: 10.1371/journal.pone.0177984. eCollection 2017.


Tenosynovitis Evaluation Using Image Fusion and B-Flow - A Pilot Study on New Imaging Techniques in Rheumatoid Arthritis Patients.

Ammitzbøll-Danielsen M, Glinatsi D, Torp-Pedersen S, Møller JM, Naredo E, Ostergaard M, Terslev L.

Ultraschall Med. 2017 Jun;38(3):285-293. doi: 10.1055/s-0043-101228. Epub 2017 May 16.


Development and Validation of the OMERACT Rheumatoid Arthritis Magnetic Resonance Tenosynovitis Scoring System in a Multireader Exercise.

Glinatsi D, Bird P, Gandjbakhch F, Haavardsholm EA, Peterfy CG, Vital EM, Emery P, Conaghan PG, Østergaard M.

J Rheumatol. 2017 Nov;44(11):1688-1693. doi: 10.3899/jrheum.161097. Epub 2017 May 1.


Increased galectin-3 may serve as a serologic signature of pre-rheumatoid arthritis while markers of synovitis and cartilage do not differ between early undifferentiated arthritis subsets.

Issa SF, Duer A, Østergaard M, Hørslev-Petersen K, Hetland ML, Hansen MS, Junker K, Lindegaard HM, Møller JM, Junker P.

Arthritis Res Ther. 2017 Apr 26;19(1):80. doi: 10.1186/s13075-017-1282-4.


Association between baseline vitamin D metabolite levels and long-term cardiovascular events in patients with rheumatoid arthritis from the CIMESTRA trial: protocol for a cohort study with patient-record evaluated outcomes.

Herly M, Stengaard-Pedersen K, Hørslev-Petersen K, Hetland ML, Østergaard M, Christensen R, Løgstrup BB, Vestergaard P, Pødenphant J, Junker P, Ellingsen T.

BMJ Open. 2017 Apr 8;7(4):e014816. doi: 10.1136/bmjopen-2016-014816.


Head-to-head comparison of aggressive conventional therapy and three biological treatments and comparison of two de-escalation strategies in patients who respond to treatment: study protocol for a multicenter, randomized, open-label, blinded-assessor, phase 4 study.

Glinatsi D, Heiberg MS, Rudin A, Nordström D, Haavardsholm EA, Gudbjornsson B, Østergaard M, Uhlig T, Grondal G, Hørslev-Petersen K, van Vollenhoven R, Hetland ML.

Trials. 2017 Apr 4;18(1):161. doi: 10.1186/s13063-017-1891-x.


Work ability in rheumatoid arthritis patients: a register study on the prospective risk of exclusion and probability of returning to work.

Hansen SM, Hetland ML, Pedersen J, Østergaard M, Rubak TS, Bjorner JB.

Rheumatology (Oxford). 2017 Jul 1;56(7):1135-1143. doi: 10.1093/rheumatology/kex064.


Letter to the Editor.

Hjorthøj C, Østergaard ML, Benros ME, Toftdahl NG, Andersen JT, Nordentoft M.

Eur J Gastroenterol Hepatol. 2017 May;29(5):615. doi: 10.1097/MEG.0000000000000816. No abstract available.


A young child with a history of wheeze.

Paton J, Bindels P, McMurray A, Biggins J, Nantanda R, Østergaard MS.

NPJ Prim Care Respir Med. 2017 Mar 16;27(1):19. doi: 10.1038/s41533-017-0020-3.


Is MRI a predictive biomarker for clinical response to biologics in rheumatoid arthritis?

Baker JF, Østergaard M, Conaghan PG.

Ann Rheum Dis. 2017 Nov;76(11):e45. doi: 10.1136/annrheumdis-2017-211265. Epub 2017 Mar 10. No abstract available.


Expression of soluble CD83 in plasma from early-stage rheumatoid arthritis patients is not modified by anti-TNF-α therapy.

Kristensen AM, Stengaard-Pedersen K, Hetland ML, Hørslev-Petersen K, Junker P, Østergaard M, Höllsberg P, Deleuran B, Hvid M.

Cytokine. 2017 Aug;96:1-7. doi: 10.1016/j.cyto.2017.02.017. Epub 2017 Mar 6.


Development and Reliability of the OMERACT Thumb Base Osteoarthritis Magnetic Resonance Imaging Scoring System.

Kroon FPB, Conaghan PG, Foltz V, Gandjbakhch F, Peterfy C, Eshed I, Genant HK, Østergaard M, Kloppenburg M, Haugen IK.

J Rheumatol. 2017 Nov;44(11):1694-1698. doi: 10.3899/jrheum.161099. Epub 2017 Mar 1.


Characterizing the effect of GalNAc and phosphorothioate backbone on binding of antisense oligonucleotides to the asialoglycoprotein receptor.

Schmidt K, Prakash TP, Donner AJ, Kinberger GA, Gaus HJ, Low A, Østergaard ME, Bell M, Swayze EE, Seth PP.

Nucleic Acids Res. 2017 Mar 17;45(5):2294-2306. doi: 10.1093/nar/gkx060.


Development and validation of rheumatoid arthritis magnetic resonance imaging inflammation thresholds associated with lack of damage progression.

Baker JF, Østergaard M, Emery P, Baker DG, Conaghan PG.

Clin Exp Rheumatol. 2017 Jul-Aug;35(4):607-613. Epub 2017 Jan 27.


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