Format
Sort by
Items per page

Send to

Choose Destination

Best matches for Ørum H[au]:

Electronic Structures of LNA Phosphorothioate Oligonucleotides. Bohr HG et al. Mol Ther Nucleic Acids. (2017)

PCR clamping. Orum H et al. Curr Issues Mol Biol. (2000)

MicroRNAs in liver disease. Wang XW et al. Gastroenterology. (2012)

Search results

Items: 1 to 50 of 58

1.

Electronic Structures of LNA Phosphorothioate Oligonucleotides.

Bohr HG, Shim I, Stein C, Ørum H, Hansen HF, Koch T.

Mol Ther Nucleic Acids. 2017 Sep 15;8:428-441. doi: 10.1016/j.omtn.2017.05.011. Epub 2017 Jun 1.

2.

Antisense-mediated reduction of proprotein convertase subtilisin/kexin type 9 (PCSK9): a first-in-human randomized, placebo-controlled trial.

van Poelgeest EP, Hodges MR, Moerland M, Tessier Y, Levin AA, Persson R, Lindholm MW, Dumong Erichsen K, Ørum H, Cohen AF, Burggraaf J.

Br J Clin Pharmacol. 2015 Dec;80(6):1350-61. doi: 10.1111/bcp.12738. Epub 2015 Oct 24.

3.

Quantum mechanical studies of DNA and LNA.

Koch T, Shim I, Lindow M, Ørum H, Bohr HG.

Nucleic Acid Ther. 2014 Apr;24(2):139-48. doi: 10.1089/nat.2013.0465. Epub 2014 Feb 3.

4.

Hepatotoxic potential of therapeutic oligonucleotides can be predicted from their sequence and modification pattern.

Hagedorn PH, Yakimov V, Ottosen S, Kammler S, Nielsen NF, Høg AM, Hedtjärn M, Meldgaard M, Møller MR, Orum H, Koch T, Lindow M.

Nucleic Acid Ther. 2013 Oct;23(5):302-10. doi: 10.1089/nat.2013.0436. Epub 2013 Aug 16.

5.

A locked nucleic acid oligonucleotide targeting microRNA 122 is well-tolerated in cynomolgus monkeys.

Hildebrandt-Eriksen ES, Aarup V, Persson R, Hansen HF, Munk ME, Ørum H.

Nucleic Acid Ther. 2012 Jun;22(3):152-61. doi: 10.1089/nat.2011.0332. Epub 2012 Apr 30.

PMID:
22545703
6.

MicroRNAs in liver disease.

Wang XW, Heegaard NH, Orum H.

Gastroenterology. 2012 Jun;142(7):1431-43. doi: 10.1053/j.gastro.2012.04.007. Epub 2012 Apr 11. Review.

7.

Does anti-TNF therapy cause any change in platelet activation in ankylosing spondylitis patients? A comparative study.

Orüm H, Pamuk GE, Pamuk ON, Demir M, Turgut B.

J Thromb Thrombolysis. 2012 Feb;33(2):154-9. doi: 10.1007/s11239-011-0663-9.

PMID:
22173846
8.

PCSK9 LNA antisense oligonucleotides induce sustained reduction of LDL cholesterol in nonhuman primates.

Lindholm MW, Elmén J, Fisker N, Hansen HF, Persson R, Møller MR, Rosenbohm C, Ørum H, Straarup EM, Koch T.

Mol Ther. 2012 Feb;20(2):376-81. doi: 10.1038/mt.2011.260. Epub 2011 Nov 22.

9.

The novel antisense Bcl-2 inhibitor SPC2996 causes rapid leukemic cell clearance and immune activation in chronic lymphocytic leukemia.

Dürig J, Dührsen U, Klein-Hitpass L, Worm J, Hansen JB, Ørum H, Wissenbach M.

Leukemia. 2011 Apr;25(4):638-47. doi: 10.1038/leu.2010.322. Epub 2011 Mar 1.

PMID:
21358717
10.

Silencing the expression of Ras family GTPase homologues decreases inflammation and joint destruction in experimental arthritis.

de Launay D, Vreijling J, Hartkamp LM, Karpus ON, Abreu JR, van Maanen MA, Sanders ME, Grabiec AM, Hamann J, Ørum H, Vervoordeldonk MJ, Fluiter K, Tak PP, Reedquist KA.

Am J Pathol. 2010 Dec;177(6):3010-24. doi: 10.2353/ajpath.2010.091053. Epub 2010 Oct 22.

11.

Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates.

Straarup EM, Fisker N, Hedtjärn M, Lindholm MW, Rosenbohm C, Aarup V, Hansen HF, Ørum H, Hansen JB, Koch T.

Nucleic Acids Res. 2010 Nov;38(20):7100-11. doi: 10.1093/nar/gkq457. Epub 2010 Jul 8.

12.

A locked nucleic acid antisense oligonucleotide (LNA) silences PCSK9 and enhances LDLR expression in vitro and in vivo.

Gupta N, Fisker N, Asselin MC, Lindholm M, Rosenbohm C, Ørum H, Elmén J, Seidah NG, Straarup EM.

PLoS One. 2010 May 17;5(5):e10682. doi: 10.1371/journal.pone.0010682.

13.

Might platelet-leucocyte complexes be playing a role in major vascular involvement of Behçet's disease? A comparative study.

Pamuk GE, Pamuk ON, Orüm H, Demir M, Turgut B, Cakir N.

Blood Coagul Fibrinolysis. 2010 Mar;21(2):113-7.

PMID:
20135752
14.

Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection.

Lanford RE, Hildebrandt-Eriksen ES, Petri A, Persson R, Lindow M, Munk ME, Kauppinen S, Ørum H.

Science. 2010 Jan 8;327(5962):198-201. doi: 10.1126/science.1178178. Epub 2009 Dec 3.

15.

Efficient gene silencing by delivery of locked nucleic acid antisense oligonucleotides, unassisted by transfection reagents.

Stein CA, Hansen JB, Lai J, Wu S, Voskresenskiy A, Høg A, Worm J, Hedtjärn M, Souleimanian N, Miller P, Soifer HS, Castanotto D, Benimetskaya L, Ørum H, Koch T.

Nucleic Acids Res. 2010 Jan;38(1):e3. doi: 10.1093/nar/gkp841. Epub 2009 Oct 23.

16.

Elevated platelet-monocyte complexes in patients with psoriatic arthritis.

Pamuk GE, Nuri Pamuk O, Orüm H, Arican O, Turgut B, Demir M.

Platelets. 2009 Nov;20(7):493-7. doi: 10.3109/09537100903165174.

PMID:
19852688
17.

MicroRNA-219 modulates NMDA receptor-mediated neurobehavioral dysfunction.

Kocerha J, Faghihi MA, Lopez-Toledano MA, Huang J, Ramsey AJ, Caron MG, Sales N, Willoughby D, Elmen J, Hansen HF, Orum H, Kauppinen S, Kenny PJ, Wahlestedt C.

Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3507-12. doi: 10.1073/pnas.0805854106. Epub 2009 Feb 5.

18.

A RNA antagonist of hypoxia-inducible factor-1alpha, EZN-2968, inhibits tumor cell growth.

Greenberger LM, Horak ID, Filpula D, Sapra P, Westergaard M, Frydenlund HF, Albaek C, Schrøder H, Ørum H.

Mol Cancer Ther. 2008 Nov;7(11):3598-608. doi: 10.1158/1535-7163.MCT-08-0510. Epub 2008 Oct 30.

19.

SPC3042: a proapoptotic survivin inhibitor.

Hansen JB, Fisker N, Westergaard M, Kjaerulff LS, Hansen HF, Thrue CA, Rosenbohm C, Wissenbach M, Orum H, Koch T.

Mol Cancer Ther. 2008 Sep;7(9):2736-45. doi: 10.1158/1535-7163.MCT-08-0161.

20.

An Endogenous TNF-α Antagonist Induced by Splice-switching Oligonucleotides Reduces Inflammation in Hepatitis and Arthritis Mouse Models.

Graziewicz MA, Tarrant TK, Buckley B, Roberts J, Fulton L, Hansen H, Ørum H, Kole R, Sazani P.

Mol Ther. 2008 Jul;16(7):1316-1322. doi: 10.1038/mt.2008.85. Epub 2016 Dec 8.

PMID:
28178484
21.

Locked nucleic acid holds promise in the treatment of cancer.

Frieden M, Ørum H.

Curr Pharm Des. 2008;14(11):1138-42. Review.

PMID:
18473860
22.

An endogenous TNF-alpha antagonist induced by splice-switching oligonucleotides reduces inflammation in hepatitis and arthritis mouse models.

Graziewicz MA, Tarrant TK, Buckley B, Roberts J, Fulton L, Hansen H, Ørum H, Kole R, Sazani P.

Mol Ther. 2008 Jul;16(7):1316-22. doi: 10.1038/mt.2008.85. Epub 2008 May 6.

23.

The application of locked nucleic acids in the treatment of cancer.

Frieden M, Orum H.

IDrugs. 2006 Oct;9(10):706-11.

PMID:
17016778
24.

Aptamers targeted to an RNA hairpin show improved specificity compared to that of complementary oligonucleotides.

Darfeuille F, Reigadas S, Hansen JB, Orum H, Di Primo C, Toulmé JJ.

Biochemistry. 2006 Oct 3;45(39):12076-82.

PMID:
17002307
25.

Secondary amyloidosis causing nephrotic syndrome in a patient with non-Hodgkin's lymphoma: quite a rare diagnosis.

Pamuk GE, Demir M, Orüm H, Turgut B, Ozyilmaz F, Tekgündüz E.

Clin Lab Haematol. 2006 Aug;28(4):259-61.

PMID:
16898966
26.

Efficient and persistent splice switching by systemically delivered LNA oligonucleotides in mice.

Roberts J, Palma E, Sazani P, Ørum H, Cho M, Kole R.

Mol Ther. 2006 Oct;14(4):471-5. Epub 2006 Jul 18.

27.

Engineering genomics. RNA antagonists--a new class of antisense drugs.

Orum H.

IEEE Eng Med Biol Mag. 2005 Jul-Aug;24(4):81-7. Review. No abstract available.

PMID:
16119218
28.

On the in vitro and in vivo properties of four locked nucleic acid nucleotides incorporated into an anti-H-Ras antisense oligonucleotide.

Fluiter K, Frieden M, Vreijling J, Rosenbohm C, De Wissel MB, Christensen SM, Koch T, Ørum H, Baas F.

Chembiochem. 2005 Jun;6(6):1104-9.

PMID:
15861430
29.

Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality.

Elmén J, Thonberg H, Ljungberg K, Frieden M, Westergaard M, Xu Y, Wahren B, Liang Z, Ørum H, Koch T, Wahlestedt C.

Nucleic Acids Res. 2005 Jan 14;33(1):439-47. Print 2005.

30.

LNA/DNA chimeric oligomers mimic RNA aptamers targeted to the TAR RNA element of HIV-1.

Darfeuille F, Hansen JB, Orum H, Di Primo C, Toulmé JJ.

Nucleic Acids Res. 2004 Jun 4;32(10):3101-7. Print 2004. Erratum in: Nucleic Acids Res. 2004 Jun 29;32(11):3512.

31.

Expanding the design horizon of antisense oligonucleotides with alpha-L-LNA.

Frieden M, Christensen SM, Mikkelsen ND, Rosenbohm C, Thrue CA, Westergaard M, Hansen HF, Ørum H, Koch T.

Nucleic Acids Res. 2003 Nov 1;31(21):6365-72.

32.

PNA synthesis using a novel Boc/acyl protecting group strategy.

Kofoed T, Hansen HF, Orum H, Koch T.

J Pept Sci. 2001 Aug;7(8):402-12.

PMID:
11548056
33.
34.
35.

PCR clamping.

Orum H.

Curr Issues Mol Biol. 2000 Jan;2(1):27-30. Review.

36.
37.
38.

A formula for thermal stability (Tm) prediction of PNA/DNA duplexes.

Giesen U, Kleider W, Berding C, Geiger A, Orum H, Nielsen PE.

Nucleic Acids Res. 1998 Nov 1;26(21):5004-6.

39.

Detection of thymine [2+2] photodimer repair in DNA: selective reaction of KMnO4.

Ramaiah D, Koch T, Orum H, Schuster GB.

Nucleic Acids Res. 1998 Sep 1;26(17):3940-3.

40.

Hairpin-forming peptide nucleic acid oligomers.

Armitage B, Ly D, Koch T, Frydenlund H, Orum H, Schuster GB.

Biochemistry. 1998 Jun 30;37(26):9417-25.

PMID:
9649324
41.

Peptide nucleic acid (PNA)/DNA hybrid duplexes: intercalation by an internally linked anthraquinone.

Armitage B, Koch T, Frydenlund H, Orum H, Schuster GB.

Nucleic Acids Res. 1998 Feb 1;26(3):715-20.

42.

Peptide nucleic acid-anthraquinone conjugates: strand invasion and photoinduced cleavage of duplex DNA.

Armitage B, Koch T, Frydenlund H, Orum H, Batz HG, Schuster GB.

Nucleic Acids Res. 1997 Nov 15;25(22):4674-8.

43.

Peptide nucleic acid-DNA duplexes: long range hole migration from an internally linked anthraquinone.

Armitage B, Ly D, Koch T, Frydenlund H, Orum H, Batz HG, Schuster GB.

Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12320-5.

44.

PNA-mediated purification of PCR amplifiable human genomic DNA from whole blood.

Seeger C, Batz HG, Orum H.

Biotechniques. 1997 Sep;23(3):512-7.

45.

Kinetics for hybridization of peptide nucleic acids (PNA) with DNA and RNA studied with the BIAcore technique.

Jensen KK, Orum H, Nielsen PE, Nordén B.

Biochemistry. 1997 Apr 22;36(16):5072-7.

PMID:
9125529
46.

Improvements in automated PNA synthesis using Boc/Z monomers.

Koch T, Hansen HF, Andersen P, Larsen T, Batz HG, Otteson K, Orum H.

J Pept Res. 1997 Jan;49(1):80-8.

PMID:
9128104
47.

One-step cloning of murine Fab gene fragments independent of IgH isotype for phage display libraries.

Andersen PS, Orum H, Engberg J.

Biotechniques. 1996 Mar;20(3):340-2. No abstract available.

48.

Sequence-specific purification of nucleic acids by PNA-controlled hybrid selection.

Orum H, Nielsen PE, Jørgensen M, Larsson C, Stanley C, Koch T.

Biotechniques. 1995 Sep;19(3):472-80.

PMID:
7495562
49.

Single base pair mutation analysis by PNA directed PCR clamping.

Orum H, Nielsen PE, Egholm M, Berg RH, Buchardt O, Stanley C.

Nucleic Acids Res. 1993 Nov 25;21(23):5332-6.

50.

Efficient method for constructing comprehensive murine Fab antibody libraries displayed on phage.

Orum H, Andersen PS, Oster A, Johansen LK, Riise E, Bjørnvad M, Svendsen I, Engberg J.

Nucleic Acids Res. 1993 Sep 25;21(19):4491-8.

Supplemental Content

Support Center