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Changes in metabolism but not myocellular signaling by training with CHO-restriction in endurance athletes.

Gejl KD, Vissing K, Hansen M, Thams L, Rokkedal-Lausch T, Plomgaard P, Meinild Lundby AK, Nybo L, Jensen K, Holmberg HC, Ørtenblad N.

Physiol Rep. 2018 Sep;6(17):e13847. doi: 10.14814/phy2.13847.


The Muscle Fiber Profiles, Mitochondrial Content, and Enzyme Activities of the Exceptionally Well-Trained Arm and Leg Muscles of Elite Cross-Country Skiers.

Ørtenblad N, Nielsen J, Boushel R, Söderlund K, Saltin B, Holmberg HC.

Front Physiol. 2018 Aug 2;9:1031. doi: 10.3389/fphys.2018.01031. eCollection 2018.


High-intensity interval, but not endurance, training induces muscle fiber type-specific subsarcolemmal lipid droplet size reduction in type 2 diabetic patients.

Koh HE, Ørtenblad N, Winding KM, Hellsten Y, Mortensen SP, Nielsen J.

Am J Physiol Endocrinol Metab. 2018 Nov 1;315(5):E872-E884. doi: 10.1152/ajpendo.00161.2018. Epub 2018 Jul 17.


Plasticity in central neural drive with short-term disuse and recovery - effects on muscle strength and influence of aging.

Hvid LG, Aagaard P, Ørtenblad N, Kjaer M, Suetta C.

Exp Gerontol. 2018 Jun;106:145-153. doi: 10.1016/j.exger.2018.02.019. Epub 2018 Feb 21.


Reliability of maximal mitochondrial oxidative phosphorylation in permeabilized fibers from the vastus lateralis employing high-resolution respirometry.

Cardinale DA, Gejl KD, Ørtenblad N, Ekblom B, Blomstrand E, Larsen FJ.

Physiol Rep. 2018 Feb;6(4). doi: 10.14814/phy2.13611.


Fundamental constraints in synchronous muscle limit superfast motor control in vertebrates.

Mead AF, Osinalde N, Ørtenblad N, Nielsen J, Brewer J, Vellema M, Adam I, Scharff C, Song Y, Frandsen U, Blagoev B, Kratchmarova I, Elemans CP.

Elife. 2017 Nov 22;6. pii: e29425. doi: 10.7554/eLife.29425.


Post-exercise recovery of contractile function and endurance in humans and mice is accelerated by heating and slowed by cooling skeletal muscle.

Cheng AJ, Willis SJ, Zinner C, Chaillou T, Ivarsson N, Ørtenblad N, Lanner JT, Holmberg HC, Westerblad H.

J Physiol. 2017 Dec 15;595(24):7413-7426. doi: 10.1113/JP274870. Epub 2017 Oct 25.


Mitochondrial increase in volume density with exercise training: More, larger or better?

Ørtenblad N.

Acta Physiol (Oxf). 2018 Jan;222(1). doi: 10.1111/apha.12976. Epub 2017 Oct 14. No abstract available.


No Superior Adaptations to Carbohydrate Periodization in Elite Endurance Athletes.

Gejl KD, Thams LB, Hansen M, Rokkedal-Lausch T, Plomgaard P, Nybo L, Larsen FJ, Cardinale DA, Jensen K, Holmberg HC, Vissing K, Ørtenblad N.

Med Sci Sports Exerc. 2017 Dec;49(12):2486-2497. doi: 10.1249/MSS.0000000000001377.


Pronounced limb and fibre type differences in subcellular lipid droplet content and distribution in elite skiers before and after exhaustive exercise.

Koh HE, Nielsen J, Saltin B, Holmberg HC, Ørtenblad N.

J Physiol. 2017 Sep 1;595(17):5781-5795. doi: 10.1113/JP274462. Epub 2017 Jul 16.


Reply from Joachim Nielsen, Kasper D. Gejl and Niels Ørtenblad.

Nielsen J, Gejl KD, Ørtenblad N.

J Physiol. 2017 May 1;595(9):2987-2988. doi: 10.1113/JP273880. No abstract available.


SPARC Interacts with Actin in Skeletal Muscle in Vitro and in Vivo.

Jørgensen LH, Jepsen PL, Boysen A, Dalgaard LB, Hvid LG, Ørtenblad N, Ravn D, Sellathurai J, Møller-Jensen J, Lochmüller H, Schrøder HD.

Am J Pathol. 2017 Feb;187(2):457-474. doi: 10.1016/j.ajpath.2016.10.013. Epub 2016 Nov 29.


Myosin content of single muscle fibers following short-term disuse and active recovery in young and old healthy men.

Hvid LG, Brocca L, Ørtenblad N, Suetta C, Aagaard P, Kjaer M, Bottinelli R, Pellegrino MA.

Exp Gerontol. 2017 Jan;87(Pt A):100-107. doi: 10.1016/j.exger.2016.10.009. Epub 2016 Oct 26.


No Muscle Is an Island: Integrative Perspectives on Muscle Fatigue.

Kent JA, Ørtenblad N, Hogan MC, Poole DC, Musch TI.

Med Sci Sports Exerc. 2016 Nov;48(11):2281-2293. Review.


The Physiological Mechanisms of Performance Enhancement with Sprint Interval Training Differ between the Upper and Lower Extremities in Humans.

Zinner C, Morales-Alamo D, Ørtenblad N, Larsen FJ, Schiffer TA, Willis SJ, Gelabert-Rebato M, Perez-Valera M, Boushel R, Calbet JA, Holmberg HC.

Front Physiol. 2016 Sep 30;7:426. eCollection 2016.


Plasticity in mitochondrial cristae density allows metabolic capacity modulation in human skeletal muscle.

Nielsen J, Gejl KD, Hey-Mogensen M, Holmberg HC, Suetta C, Krustrup P, Elemans CPH, Ørtenblad N.

J Physiol. 2017 May 1;595(9):2839-2847. doi: 10.1113/JP273040. Epub 2016 Nov 13.


Local depletion of glycogen with supramaximal exercise in human skeletal muscle fibres.

Gejl KD, Ørtenblad N, Andersson E, Plomgaard P, Holmberg HC, Nielsen J.

J Physiol. 2017 May 1;595(9):2809-2821. doi: 10.1113/JP273109. Epub 2016 Nov 8.


Metabolic Responses and Pacing Strategies during Successive Sprint Skiing Time Trials.

Andersson E, Holmberg HC, Ørtenblad N, Björklund G.

Med Sci Sports Exerc. 2016 Dec;48(12):2544-2554.


Energy system contributions and determinants of performance in sprint cross-country skiing.

Andersson E, Björklund G, Holmberg HC, Ørtenblad N.

Scand J Med Sci Sports. 2017 Apr;27(4):385-398. doi: 10.1111/sms.12666. Epub 2016 Feb 29.


Muscle glycogen and cell function--Location, location, location.

Ørtenblad N, Nielsen J.

Scand J Med Sci Sports. 2015 Dec;25 Suppl 4:34-40. doi: 10.1111/sms.12599. Review.


High-intensity sprint training inhibits mitochondrial respiration through aconitase inactivation.

Larsen FJ, Schiffer TA, Ørtenblad N, Zinner C, Morales-Alamo D, Willis SJ, Calbet JA, Holmberg HC, Boushel R.

FASEB J. 2016 Jan;30(1):417-27. doi: 10.1096/fj.15-276857. Epub 2015 Oct 9.


Skeletal muscle fiber characteristics and oxidative capacity in hemiparetic stroke survivors.

Severinsen K, Dalgas U, Overgaard K, Pedersen AR, Ørtenblad N, Lund C, Jakobsen JK, Andersen H.

Muscle Nerve. 2016 May;53(5):748-54. doi: 10.1002/mus.24907. Epub 2016 Feb 26.


Mechanisms underlying enhancements in muscle force and power output during maximal cycle ergometer exercise induced by chronic β2-adrenergic stimulation in men.

Hostrup M, Kalsen A, Onslev J, Jessen S, Haase C, Habib S, Ørtenblad N, Backer V, Bangsbo J.

J Appl Physiol (1985). 2015 Sep 1;119(5):475-86. doi: 10.1152/japplphysiol.00319.2015. Epub 2015 Jul 9.


Repeated high-intensity exercise modulates Ca(2+) sensitivity of human skeletal muscle fibers.

Gejl KD, Hvid LG, Willis SJ, Andersson E, Holmberg HC, Jensen R, Frandsen U, Hansen J, Plomgaard P, Ørtenblad N.

Scand J Med Sci Sports. 2016 May;26(5):488-97. doi: 10.1111/sms.12483. Epub 2015 May 5.


Carbohydrate restricted recovery from long term endurance exercise does not affect gene responses involved in mitochondrial biogenesis in highly trained athletes.

Jensen L, Gejl KD, Ørtenblad N, Nielsen JL, Bech RD, Nygaard T, Sahlin K, Frandsen U.

Physiol Rep. 2015 Feb 12;3(2). pii: e12184. doi: 10.14814/phy2.12184. Print 2015 Feb 1.


β2-adrenergic stimulation enhances Ca2+ release and contractile properties of skeletal muscles, and counteracts exercise-induced reductions in Na+-K+-ATPase Vmax in trained men.

Hostrup M, Kalsen A, Ortenblad N, Juel C, Mørch K, Rzeppa S, Karlsson S, Backer V, Bangsbo J.

J Physiol. 2014 Dec 15;592(24):5445-59. doi: 10.1113/jphysiol.2014.277095. Epub 2014 Oct 24.


McArdle disease: a unique study model in sports medicine.

Santalla A, Nogales-Gadea G, Ørtenblad N, Brull A, de Luna N, Pinós T, Lucia A.

Sports Med. 2014 Nov;44(11):1531-44. doi: 10.1007/s40279-014-0223-5. Review.


Subcellular distribution of glycogen and decreased tetanic Ca2+ in fatigued single intact mouse muscle fibres.

Nielsen J, Cheng AJ, Ørtenblad N, Westerblad H.

J Physiol. 2014 May 1;592(9):2003-12. doi: 10.1113/jphysiol.2014.271528. Epub 2014 Mar 3.


A PGC-1α- and muscle fibre type-related decrease in markers of mitochondrial oxidative metabolism in skeletal muscle of humans with inherited insulin resistance.

Kristensen JM, Skov V, Petersson SJ, Ørtenblad N, Wojtaszewski JF, Beck-Nielsen H, Højlund K.

Diabetologia. 2014 May;57(5):1006-15. doi: 10.1007/s00125-014-3187-y. Epub 2014 Feb 9.


Aging impairs the recovery in mechanical muscle function following 4 days of disuse.

Hvid LG, Suetta C, Nielsen JH, Jensen MM, Frandsen U, Ørtenblad N, Kjaer M, Aagaard P.

Exp Gerontol. 2014 Apr;52:1-8. doi: 10.1016/j.exger.2014.01.012. Epub 2014 Jan 18.


Muscle glycogen content modifies SR Ca2+ release rate in elite endurance athletes.

Gejl KD, Hvid LG, Frandsen U, Jensen K, Sahlin K, Ørtenblad N.

Med Sci Sports Exerc. 2014 Mar;46(3):496-505. doi: 10.1249/MSS.0000000000000132.


Muscle glycogen stores and fatigue.

Ørtenblad N, Westerblad H, Nielsen J.

J Physiol. 2013 Sep 15;591(18):4405-13. doi: 10.1113/jphysiol.2013.251629. Epub 2013 May 7. Review.


Transient impairments in single muscle fibre contractile function after prolonged cycling in elite endurance athletes.

Hvid LG, Gejl K, Bech RD, Nygaard T, Jensen K, Frandsen U, Ørtenblad N.

Acta Physiol (Oxf). 2013 Jul;208(3):265-73. doi: 10.1111/apha.12095. Epub 2013 Apr 6.


Physiological aspects of the subcellular localization of glycogen in skeletal muscle.

Nielsen J, Ørtenblad N.

Appl Physiol Nutr Metab. 2013 Feb;38(2):91-9. doi: 10.1139/apnm-2012-0184. Epub 2012 Nov 9. Review.


Four days of muscle disuse impairs single fiber contractile function in young and old healthy men.

Hvid LG, Suetta C, Aagaard P, Kjaer M, Frandsen U, Ørtenblad N.

Exp Gerontol. 2013 Feb;48(2):154-61. doi: 10.1016/j.exger.2012.11.005. Epub 2012 Dec 3.


Both short intense and prolonged moderate in vitro stimulation reduce the mRNA expression of calcium-regulatory proteins in rat skeletal muscle.

Mänttäri S, Ørtenblad N, Madsen K, Pilegaard H.

Mol Cell Biochem. 2013 Jan;373(1-2):171-8. doi: 10.1007/s11010-012-1486-5. Epub 2012 Oct 31.


Effects of β₂-agonists on force during and following anoxia in rat extensor digitorum longus muscle.

Fredsted A, Gissel H, Ortenblad N, Clausen T.

J Appl Physiol (1985). 2012 Jun;112(12):2057-67. doi: 10.1152/japplphysiol.01558.2011. Epub 2012 Apr 5.


Skeletal muscle glycogen content and particle size of distinct subcellular localizations in the recovery period after a high-level soccer match.

Nielsen J, Krustrup P, Nybo L, Gunnarsson TP, Madsen K, Schrøder HD, Bangsbo J, Ortenblad N.

Eur J Appl Physiol. 2012 Oct;112(10):3559-67. doi: 10.1007/s00421-012-2341-9. Epub 2012 Feb 10.


Effects of ageing on single muscle fibre contractile function following short-term immobilisation.

Hvid LG, Ortenblad N, Aagaard P, Kjaer M, Suetta C.

J Physiol. 2011 Oct 1;589(Pt 19):4745-57. doi: 10.1113/jphysiol.2011.215434. Epub 2011 Aug 8.


Human skeletal muscle glycogen utilization in exhaustive exercise: role of subcellular localization and fibre type.

Nielsen J, Holmberg HC, Schrøder HD, Saltin B, Ortenblad N.

J Physiol. 2011 Jun 1;589(Pt 11):2871-85. doi: 10.1113/jphysiol.2010.204487. Epub 2011 Apr 4.


Maximal voluntary contraction force, SR function and glycogen resynthesis during the first 72 h after a high-level competitive soccer game.

Krustrup P, Ortenblad N, Nielsen J, Nybo L, Gunnarsson TP, Iaia FM, Madsen K, Stephens F, Greenhaff P, Bangsbo J.

Eur J Appl Physiol. 2011 Dec;111(12):2987-95. doi: 10.1007/s00421-011-1919-y. Epub 2011 Mar 30.


Role of glycogen availability in sarcoplasmic reticulum Ca2+ kinetics in human skeletal muscle.

Ørtenblad N, Nielsen J, Saltin B, Holmberg HC.

J Physiol. 2011 Feb 1;589(Pt 3):711-25. doi: 10.1113/jphysiol.2010.195982. Epub 2010 Dec 6.


Lactate per se improves the excitability of depolarized rat skeletal muscle by reducing the Cl- conductance.

de Paoli FV, Ørtenblad N, Pedersen TH, Jørgensen R, Nielsen OB.

J Physiol. 2010 Dec 1;588(Pt 23):4785-94. doi: 10.1113/jphysiol.2010.196568. Epub 2010 Sep 27.


Effects of aging on muscle mechanical function and muscle fiber morphology during short-term immobilization and subsequent retraining.

Hvid L, Aagaard P, Justesen L, Bayer ML, Andersen JL, Ørtenblad N, Kjaer M, Suetta C.

J Appl Physiol (1985). 2010 Dec;109(6):1628-34. doi: 10.1152/japplphysiol.00637.2010. Epub 2010 Sep 23.


Subcellular localization-dependent decrements in skeletal muscle glycogen and mitochondria content following short-term disuse in young and old men.

Nielsen J, Suetta C, Hvid LG, Schrøder HD, Aagaard P, Ortenblad N.

Am J Physiol Endocrinol Metab. 2010 Dec;299(6):E1053-60. doi: 10.1152/ajpendo.00324.2010. Epub 2010 Sep 21.


Increased subsarcolemmal lipids in type 2 diabetes: effect of training on localization of lipids, mitochondria, and glycogen in sedentary human skeletal muscle.

Nielsen J, Mogensen M, Vind BF, Sahlin K, Højlund K, Schrøder HD, Ortenblad N.

Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E706-13. doi: 10.1152/ajpendo.00692.2009. Epub 2009 Dec 22.


Effects of aging on human skeletal muscle after immobilization and retraining.

Suetta C, Hvid LG, Justesen L, Christensen U, Neergaard K, Simonsen L, Ortenblad N, Magnusson SP, Kjaer M, Aagaard P.

J Appl Physiol (1985). 2009 Oct;107(4):1172-80. doi: 10.1152/japplphysiol.00290.2009. Epub 2009 Aug 6.


Distinct effects of subcellular glycogen localization on tetanic relaxation time and endurance in mechanically skinned rat skeletal muscle fibres.

Nielsen J, Schrøder HD, Rix CG, Ortenblad N.

J Physiol. 2009 Jul 15;587(Pt 14):3679-90. doi: 10.1113/jphysiol.2009.174862. Epub 2009 May 26.


Glycolysis in contracting rat skeletal muscle is controlled by factors related to energy state.

Ortenblad N, Macdonald WA, Sahlin K.

Biochem J. 2009 May 13;420(2):161-8. doi: 10.1042/BJ20082135.


Reduced sarcoplasmic reticulum content of releasable Ca2+ in rat soleus muscle fibres after eccentric contractions.

Nielsen JS, Sahlin K, Ørtenblad N.

Acta Physiol (Oxf). 2007 Nov;191(3):217-28. Epub 2007 Jul 17.


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