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Items: 1 to 50 of 204

1.

ITGA5 inhibition in pancreatic stellate cells attenuates desmoplasia and potentiates efficacy of chemotherapy in pancreatic cancer.

Kuninty PR, Bansal R, De Geus SWL, Mardhian DF, Schnittert J, van Baarlen J, Storm G, Bijlsma MF, van Laarhoven HW, Metselaar JM, Kuppen PJK, Vahrmeijer AL, Östman A, Sier CFM, Prakash J.

Sci Adv. 2019 Sep 4;5(9):eaax2770. doi: 10.1126/sciadv.aax2770. eCollection 2019 Sep.

2.

Astrocytes enhance glioblastoma growth.

Mega A, Hartmark Nilsen M, Leiss LW, Tobin NP, Miletic H, Sleire L, Strell C, Nelander S, Krona C, Hägerstrand D, Enger PØ, Nistér M, Östman A.

Glia. 2019 Sep 11. doi: 10.1002/glia.23718. [Epub ahead of print]

PMID:
31509308
3.

Differential prognostic impact of platelet-derived growth factor receptor expression in NSCLC.

Kilvaer TK, Rakaee M, Hellevik T, Vik J, Petris L, Donnem T, Strell C, Ostman A, Busund LR, Martinez-Zubiaurre I.

Sci Rep. 2019 Jul 15;9(1):10163. doi: 10.1038/s41598-019-46510-3.

4.

Stroma-normalised vessel density predicts benefit from adjuvant fluorouracil-based chemotherapy in patients with stage II/III colon cancer.

Mezheyeuski A, Hrynchyk I, Herrera M, Karlberg M, Osterman E, Ragnhammar P, Edler D, Portyanko A, Ponten F, Sjöblom T, Glimelius B, Östman A.

Br J Cancer. 2019 Aug;121(4):303-311. doi: 10.1038/s41416-019-0519-1. Epub 2019 Jul 10.

PMID:
31289351
5.

Fibroblast as a critical stromal cell type determining prognosis in prostate cancer.

Blom S, Erickson A, Östman A, Rannikko A, Mirtti T, Kallioniemi O, Pellinen T.

Prostate. 2019 Sep;79(13):1505-1513. doi: 10.1002/pros.23867. Epub 2019 Jul 3.

PMID:
31269283
6.

Inhibition of diverse opportunistic viruses by structurally optimized retrograde trafficking inhibitors.

Desai D, Lauver M, Ostman A, Cruz L, Ferguson K, Jin G, Roper B, Brosius D, Lukacher A, Amin S, Buchkovich N.

Bioorg Med Chem. 2019 May 1;27(9):1795-1803. doi: 10.1016/j.bmc.2019.03.026. Epub 2019 Mar 13.

PMID:
30890396
7.

A Novel ACKR2-Dependent Role of Fibroblast-Derived CXCL14 in Epithelial-to-Mesenchymal Transition and Metastasis of Breast Cancer.

Sjöberg E, Meyrath M, Milde L, Herrera M, Lövrot J, Hägerstrand D, Frings O, Bartish M, Rolny C, Sonnhammer E, Chevigné A, Augsten M, Östman A.

Clin Cancer Res. 2019 Jun 15;25(12):3702-3717. doi: 10.1158/1078-0432.CCR-18-1294. Epub 2019 Mar 8.

PMID:
30850359
8.

Impact of Epithelial-Stromal Interactions on Peritumoral Fibroblasts in Ductal Carcinoma in Situ.

Strell C, Paulsson J, Jin SB, Tobin NP, Mezheyeuski A, Roswall P, Mutgan C, Mitsios N, Johansson H, Wickberg SM, Svedlund J, Nilsson M, Hall P, Mulder J, Radisky DC, Pietras K, Bergh J, Lendahl U, Wärnberg F, Östman A.

J Natl Cancer Inst. 2019 Sep 1;111(9):983-995. doi: 10.1093/jnci/djy234.

PMID:
30816935
9.

Integrin α11 in pancreatic stellate cells regulates tumor stroma interaction in pancreatic cancer.

Schnittert J, Bansal R, Mardhian DF, van Baarlen J, Östman A, Prakash J.

FASEB J. 2019 May;33(5):6609-6621. doi: 10.1096/fj.201802336R. Epub 2019 Feb 26.

PMID:
30808244
10.

Microvascular Mural Cells in Cancer.

Östman A, Corvigno S.

Trends Cancer. 2018 Dec;4(12):838-848. doi: 10.1016/j.trecan.2018.10.004. Epub 2018 Oct 28. Review.

PMID:
30470305
11.

A minority-group of renal cell cancer patients with high infiltration of CD20+B-cells is associated with poor prognosis.

Sjöberg E, Frödin M, Lövrot J, Mezheyeuski A, Johansson M, Harmenberg U, Egevad L, Sandström P, Östman A.

Br J Cancer. 2018 Oct;119(7):840-846. doi: 10.1038/s41416-018-0266-8. Epub 2018 Oct 8.

12.

Irreversible inhibition of cytosolic thioredoxin reductase 1 as a mechanistic basis for anticancer therapy.

Stafford WC, Peng X, Olofsson MH, Zhang X, Luci DK, Lu L, Cheng Q, Trésaugues L, Dexheimer TS, Coussens NP, Augsten M, Ahlzén HM, Orwar O, Östman A, Stone-Elander S, Maloney DJ, Jadhav A, Simeonov A, Linder S, Arnér ESJ.

Sci Transl Med. 2018 Feb 14;10(428). pii: eaaf7444. doi: 10.1126/scitranslmed.aaf7444.

PMID:
29444979
13.

Tissue analyses reveal a potential immune-adjuvant function of FAP-1 positive fibroblasts in non-small cell lung cancer.

Kilvaer TK, Rakaee M, Hellevik T, Østman A, Strell C, Bremnes RM, Busund LT, Dønnem T, Martinez-Zubiaurre I.

PLoS One. 2018 Feb 7;13(2):e0192157. doi: 10.1371/journal.pone.0192157. eCollection 2018.

14.

Publisher Correction: Whole-tissue biopsy phenotyping of three-dimensional tumours reveals patterns of cancer heterogeneity.

Tanaka N, Kanatani S, Tomer R, Sahlgren C, Kronqvist P, Kaczynska D, Louhivuori L, Kis L, Lindh C, Mitura P, Stepulak A, Corvigno S, Hartman J, Micke P, Mezheyeuski A, Strell C, Carlson JW, Fernández Moro C, Dahlstrand H, Östman A, Matsumoto K, Wiklund P, Oya M, Miyakawa A, Deisseroth K, Uhlén P.

Nat Biomed Eng. 2018 Jan;2(1):48. doi: 10.1038/s41551-017-0162-1.

PMID:
31015657
15.

Treatment-related survival associations of claudin-2 expression in fibroblasts of colorectal cancer.

Mezheyeuski A, Strell C, Hrynchyk I, Guren TK, Dragomir A, Doroshenko T, Pashkova O, Gorgun J, Ruksha K, Pfeiffer P, Kure EH, Sorbye H, Edler D, Martling A, Glimelius B, Östman A, Portyanko A.

Virchows Arch. 2018 Mar;472(3):395-405. doi: 10.1007/s00428-017-2263-3. Epub 2017 Nov 13.

16.

PDGF receptors in tumor stroma: Biological effects and associations with prognosis and response to treatment.

Östman A.

Adv Drug Deliv Rev. 2017 Nov 1;121:117-123. doi: 10.1016/j.addr.2017.09.022. Epub 2017 Sep 29. Review.

PMID:
28970051
17.

Whole-tissue biopsy phenotyping of three-dimensional tumours reveals patterns of cancer heterogeneity.

Tanaka N, Kanatani S, Tomer R, Sahlgren C, Kronqvist P, Kaczynska D, Louhivuori L, Kis L, Lindh C, Mitura P, Stepulak A, Corvigno S, Hartman J, Micke P, Mezheyeuski A, Strell C, Carlson JW, Fernández Moro C, Dahlstrand H, Östman A, Matsumoto K, Wiklund P, Oya M, Miyakawa A, Deisseroth K, Uhlén P.

Nat Biomed Eng. 2017 Oct;1(10):796-806. doi: 10.1038/s41551-017-0139-0. Epub 2017 Oct 2. Erratum in: Nat Biomed Eng. 2018 Jan;2(1):48.

PMID:
31015588
18.

Multi-parametric profiling of renal cell, colorectal, and ovarian cancer identifies tumour-type-specific stroma phenotypes and a novel vascular biomarker.

Corvigno S, Frödin M, Wisman GBA, Nijman HW, Van der Zee AG, Jirström K, Nodin B, Hrynchyk I, Edler D, Ragnhammar P, Johansson M, Dahlstrand H, Mezheyeuski A, Östman A.

J Pathol Clin Res. 2017 Jul 24;3(3):214-224. doi: 10.1002/cjp2.74. eCollection 2017 Jul.

19.

Thioredoxin reductase 1 and NADPH directly protect protein tyrosine phosphatase 1B from inactivation during H2O2 exposure.

Dagnell M, Pace PE, Cheng Q, Frijhoff J, Östman A, Arnér ESJ, Hampton MB, Winterbourn CC.

J Biol Chem. 2017 Sep 1;292(35):14371-14380. doi: 10.1074/jbc.M117.793745. Epub 2017 Jul 6.

20.

Human cancer-associated fibroblasts enhance glutathione levels and antagonize drug-induced prostate cancer cell death.

Cheteh EH, Augsten M, Rundqvist H, Bianchi J, Sarne V, Egevad L, Bykov VJ, Östman A, Wiman KG.

Cell Death Dis. 2017 Jun 1;8(6):e2848. doi: 10.1038/cddis.2017.225.

21.

Stroma-regulated HMGA2 is an independent prognostic marker in PDAC and AAC.

Strell C, Norberg KJ, Mezheyeuski A, Schnittert J, Kuninty PR, Moro CF, Paulsson J, Schultz NA, Calatayud D, Löhr JM, Frings O, Verbeke CS, Heuchel RL, Prakash J, Johansen JS, Östman A.

Br J Cancer. 2017 Jun 27;117(1):65-77. doi: 10.1038/bjc.2017.140. Epub 2017 May 18.

22.

High expression of stromal PDGFRβ is associated with reduced benefit of tamoxifen in breast cancer.

Paulsson J, Rydén L, Strell C, Frings O, Tobin NP, Fornander T, Bergh J, Landberg G, Stål O, Östman A.

J Pathol Clin Res. 2016 Sep 14;3(1):38-43. doi: 10.1002/cjp2.56. eCollection 2017 Jan.

23.

Perivascular PDGFR-β is an independent marker for prognosis in renal cell carcinoma.

Frödin M, Mezheyeuski A, Corvigno S, Harmenberg U, Sandström P, Egevad L, Johansson M, Östman A.

Br J Cancer. 2017 Jan 17;116(2):195-201. doi: 10.1038/bjc.2016.407. Epub 2016 Dec 8.

24.

Image analysis-derived metrics of histomorphological complexity predicts prognosis and treatment response in stage II-III colon cancer.

Mezheyeuski A, Hrynchyk I, Karlberg M, Portyanko A, Egevad L, Ragnhammar P, Edler D, Glimelius B, Östman A.

Sci Rep. 2016 Nov 2;6:36149. doi: 10.1038/srep36149.

25.

Glioma-induced inhibition of caspase-3 in microglia promotes a tumor-supportive phenotype.

Shen X, Burguillos MA, Osman AM, Frijhoff J, Carrillo-Jiménez A, Kanatani S, Augsten M, Saidi D, Rodhe J, Kavanagh E, Rongvaux A, Rraklli V, Nyman U, Holmberg J, Östman A, Flavell RA, Barragan A, Venero JL, Blomgren K, Joseph B.

Nat Immunol. 2016 Nov;17(11):1282-1290. doi: 10.1038/ni.3545. Epub 2016 Sep 12.

PMID:
27618552
26.

Amount of stroma is associated with mammographic density and stromal expression of oestrogen receptor in normal breast tissues.

Gabrielson M, Chiesa F, Paulsson J, Strell C, Behmer C, Rönnow K, Czene K, Östman A, Hall P.

Breast Cancer Res Treat. 2016 Jul;158(2):253-61. doi: 10.1007/s10549-016-3877-x. Epub 2016 Jun 27.

PMID:
27349429
27.

Survival-associated heterogeneity of marker-defined perivascular cells in colorectal cancer.

Mezheyeuski A, Bradic Lindh M, Guren TK, Dragomir A, Pfeiffer P, Kure EH, Ikdahl T, Skovlund E, Corvigno S, Strell C, Pietras K, Ponten F, Mulder J, Qvortrup C, Portyanko A, Tveit KM, Glimelius B, Sorbye H, Östman A.

Oncotarget. 2016 Jul 5;7(27):41948-41958. doi: 10.18632/oncotarget.9632.

28.

Guidance Molecule SEMA3A Restricts Tumor Growth by Differentially Regulating the Proliferation of Tumor-Associated Macrophages.

Wallerius M, Wallmann T, Bartish M, Östling J, Mezheyeuski A, Tobin NP, Nygren E, Pangigadde P, Pellegrini P, Squadrito ML, Pontén F, Hartman J, Bergh J, De Milito A, De Palma M, Östman A, Andersson J, Rolny C.

Cancer Res. 2016 Jun 1;76(11):3166-78. doi: 10.1158/0008-5472.CAN-15-2596. Epub 2016 Apr 6.

29.

Expression of the chemokine CXCL14 in the tumour stroma is an independent marker of survival in breast cancer.

Sjöberg E, Augsten M, Bergh J, Jirström K, Östman A.

Br J Cancer. 2016 May 10;114(10):1117-24. doi: 10.1038/bjc.2016.104. Epub 2016 Apr 26.

30.

Inhibition of Src homology 2 domain-containing phosphatase 1 increases insulin sensitivity in high-fat diet-induced insulin-resistant mice.

Krüger J, Wellnhofer E, Meyborg H, Stawowy P, Östman A, Kintscher U, Kappert K.

FEBS Open Bio. 2016 Jan 4;6(3):179-89. doi: 10.1002/2211-5463.12000. eCollection 2016 Mar.

31.

MicroRNA-199a and -214 as potential therapeutic targets in pancreatic stellate cells in pancreatic tumor.

Kuninty PR, Bojmar L, Tjomsland V, Larsson M, Storm G, Östman A, Sandström P, Prakash J.

Oncotarget. 2016 Mar 29;7(13):16396-408. doi: 10.18632/oncotarget.7651.

32.

Markers of fibroblast-rich tumor stroma and perivascular cells in serous ovarian cancer: Inter- and intra-patient heterogeneity and impact on survival.

Corvigno S, Wisman GB, Mezheyeuski A, van der Zee AG, Nijman HW, Åvall-Lundqvist E, Östman A, Dahlstrand H.

Oncotarget. 2016 Apr 5;7(14):18573-84. doi: 10.18632/oncotarget.7613.

33.

An Endothelial Gene Signature Score Predicts Poor Outcome in Patients with Endocrine-Treated, Low Genomic Grade Breast Tumors.

Tobin NP, Wennmalm K, Lindström LS, Foukakis T, He L, Genové G, Östman A, Landberg G, Betsholtz C, Bergh J.

Clin Cancer Res. 2016 May 15;22(10):2417-26. doi: 10.1158/1078-0432.CCR-15-1691. Epub 2016 Jan 14.

34.

Role of Tumor Pericytes in the Recruitment of Myeloid-Derived Suppressor Cells.

Hong J, Tobin NP, Rundqvist H, Li T, Lavergne M, García-Ibáñez Y, Qin H, Paulsson J, Zeitelhofer M, Adzemovic MZ, Nilsson I, Roswall P, Hartman J, Johnson RS, Östman A, Bergh J, Poljakovic M, Genové G.

J Natl Cancer Inst. 2015 Aug 21;107(10). pii: djv209. doi: 10.1093/jnci/djv209. Print 2015 Oct. Erratum in: J Natl Cancer Inst. 2016 Mar;108(3). pii: djv434. doi: 10.1093/jnci/djv434.

35.

SIRT1 inhibition in pancreatic cancer models: contrasting effects in vitro and in vivo.

Oon CE, Strell C, Yeong KY, Östman A, Prakash J.

Eur J Pharmacol. 2015 Jun 15;757:59-67. doi: 10.1016/j.ejphar.2015.03.064. Epub 2015 Apr 3.

PMID:
25843411
36.

Enhanced insulin signaling in density-enhanced phosphatase-1 (DEP-1) knockout mice.

Krüger J, Brachs S, Trappiel M, Kintscher U, Meyborg H, Wellnhofer E, Thöne-Reineke C, Stawowy P, Östman A, Birkenfeld AL, Böhmer FD, Kappert K.

Mol Metab. 2015 Feb 12;4(4):325-36. doi: 10.1016/j.molmet.2015.02.001. eCollection 2015 Apr.

37.

Inter- and intra-tumoral relationships between vasculature characteristics, GLUT1 and budding in colorectal carcinoma.

Mezheyeuski A, Nerovnya A, Bich T, Tur G, Ostman A, Portyanko A.

Histol Histopathol. 2015 Oct;30(10):1203-11. doi: 10.14670/HH-11-613. Epub 2015 Mar 26.

PMID:
25811313
38.

Knockout of mitochondrial thioredoxin reductase stabilizes prolyl hydroxylase 2 and inhibits tumor growth and tumor-derived angiogenesis.

Hellfritsch J, Kirsch J, Schneider M, Fluege T, Wortmann M, Frijhoff J, Dagnell M, Fey T, Esposito I, Kölle P, Pogoda K, Angeli JP, Ingold I, Kuhlencordt P, Östman A, Pohl U, Conrad M, Beck H.

Antioxid Redox Signal. 2015 Apr 10;22(11):938-50. doi: 10.1089/ars.2014.5889.

39.

Preclinical evaluation of dasatinib alone and in combination with cabozantinib for the treatment of diffuse intrinsic pontine glioma.

Truffaux N, Philippe C, Paulsson J, Andreiuolo F, Guerrini-Rousseau L, Cornilleau G, Le Dret L, Richon C, Lacroix L, Puget S, Geoerger B, Vassal G, Östman A, Grill J.

Neuro Oncol. 2015 Jul;17(7):953-64. doi: 10.1093/neuonc/nou330. Epub 2014 Dec 21.

40.

microRNA expression signatures of gastrointestinal stromal tumours: associations with imatinib resistance and patient outcome.

Akçakaya P, Caramuta S, Åhlen J, Ghaderi M, Berglund E, Östman A, Bränström R, Larsson C, Lui WO.

Br J Cancer. 2014 Nov 25;111(11):2091-102. doi: 10.1038/bjc.2014.548. Epub 2014 Oct 30.

41.

PDGF receptors in tumor biology: prognostic and predictive potential.

Paulsson J, Ehnman M, Östman A.

Future Oncol. 2014;10(9):1695-708. doi: 10.2217/fon.14.83. Review.

PMID:
25145436
42.

Hydrolysis and composition of recovered fibres fractionated from solid recovered fuel.

Kemppainen K, Siika-Aho M, Östman A, Sipilä E, Puranen T, von Weymarn N, Kruus K.

Bioresour Technol. 2014 Oct;169:88-95. doi: 10.1016/j.biortech.2014.06.069. Epub 2014 Jun 26.

PMID:
25033328
43.

Effects of epigenetic modificators in combination with small molecule inhibitors of receptor tyrosine kinases on medulloblastoma growth.

Marino AM, Frijhoff J, Calero R, Baryawno N, Ostman A, Johnsen JI.

Biochem Biophys Res Commun. 2014 Aug 8;450(4):1600-5. doi: 10.1016/j.bbrc.2014.07.042. Epub 2014 Jul 12.

PMID:
25026552
44.

Inhibition of protein tyrosine phosphatases enhances cerebral collateral growth in rats.

Buschmann I, Hackbusch D, Gatzke N, Dülsner A, Trappiel M, Dagnell M, Ostman A, Hooft van Huijsduijnen R, Kappert K.

J Mol Med (Berl). 2014 Sep;92(9):983-94. doi: 10.1007/s00109-014-1164-z. Epub 2014 May 27.

PMID:
24858946
45.

Local and systemic protumorigenic effects of cancer-associated fibroblast-derived GDF15.

Bruzzese F, Hägglöf C, Leone A, Sjöberg E, Roca MS, Kiflemariam S, Sjöblom T, Hammarsten P, Egevad L, Bergh A, Ostman A, Budillon A, Augsten M.

Cancer Res. 2014 Jul 1;74(13):3408-17. doi: 10.1158/0008-5472.CAN-13-2259. Epub 2014 Apr 29.

46.

Cancer-associated fibroblasts expressing CXCL14 rely upon NOS1-derived nitric oxide signaling for their tumor-supporting properties.

Augsten M, Sjöberg E, Frings O, Vorrink SU, Frijhoff J, Olsson E, Borg Å, Östman A.

Cancer Res. 2014 Jun 1;74(11):2999-3010. doi: 10.1158/0008-5472.CAN-13-2740. Epub 2014 Apr 7.

47.

Cancer-associated fibroblasts: recent developments and emerging challenges.

Östman A.

Semin Cancer Biol. 2014 Apr;25:1-2. doi: 10.1016/j.semcancer.2014.02.004. Epub 2014 Feb 18. No abstract available.

PMID:
24561109
48.

The mitochondrial reactive oxygen species regulator p66Shc controls PDGF-induced signaling and migration through protein tyrosine phosphatase oxidation.

Frijhoff J, Dagnell M, Augsten M, Beltrami E, Giorgio M, Östman A.

Free Radic Biol Med. 2014 Mar;68:268-77. doi: 10.1016/j.freeradbiomed.2013.12.022. Epub 2013 Dec 27.

PMID:
24378437
49.

Therapeutic targeting of platelet-derived growth factor receptors in solid tumors.

Ehnman M, Östman A.

Expert Opin Investig Drugs. 2014 Feb;23(2):211-26. doi: 10.1517/13543784.2014.847086. Epub 2013 Nov 11. Review.

PMID:
24206431
50.

Regulation of protein tyrosine phosphatase oxidation in cell adhesion and migration.

Frijhoff J, Dagnell M, Godfrey R, Ostman A.

Antioxid Redox Signal. 2014 May 1;20(13):1994-2010. doi: 10.1089/ars.2013.5643. Epub 2014 Mar 10. Review.

PMID:
24111825

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