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Items: 43

1.

Mapping Aldehyde Dehydrogenase 1A1 Activity using an [18F]Substrate-based Approach.

Pereira R, Gendron T, Sanghera C, Greenwood HE, Newcombe J, McCormick P, Sander K, Topf M, Årstad E, Witney TH.

Chemistry. 2018 Dec 6. doi: 10.1002/chem.201805473. [Epub ahead of print]

PMID:
30521138
2.

Assessment of tumor redox status through (S)-4-(3-[18F]fluoropropyl)-L-glutamic acid positron emission tomography imaging of system xc- activity.

McCormick PN, Greenwood HE, Glaser M, Maddocks ODK, Gendron T, Sander K, Gowrishankar G, Hoehne A, Zhang T, Shuhendler AJ, Lewis DY, Berndt M, Koglin N, Lythgoe MF, Gambhir SS, Årstad E, Witney TH.

Cancer Res. 2018 Nov 6. pii: canres.2634.2018. doi: 10.1158/0008-5472.CAN-18-2634. [Epub ahead of print]

PMID:
30401715
3.

Comment on " In Vivo [18F]GE-179 Brain Signal Does Not Show NMDA-Specific Modulation with Drug Challenges in Rodents and Nonhuman Primates".

McGinnity CJ, Årstad E, Beck K, Brooks DJ, Coles JP, Duncan JS, Galovic M, Hinz R, Hirani E, Howes OD, Jones PA, Koepp MJ, Luo F, Riaño Barros DA, Singh N, Trigg W, Hammers A.

ACS Chem Neurosci. 2018 Oct 11. doi: 10.1021/acschemneuro.8b00246. [Epub ahead of print]

PMID:
30346706
4.

Ring-Closing Synthesis of Dibenzothiophene Sulfonium Salts and Their Use as Leaving Groups for Aromatic 18F-Fluorination.

Gendron T, Sander K, Cybulska K, Benhamou L, Sin PKB, Khan A, Wood M, Porter MJ, Årstad E.

J Am Chem Soc. 2018 Sep 5;140(35):11125-11132. doi: 10.1021/jacs.8b06730. Epub 2018 Aug 22.

5.

Large inter- and intra-case variability of first generation tau PET ligand binding in neurodegenerative dementias.

Wren MC, Lashley T, Årstad E, Sander K.

Acta Neuropathol Commun. 2018 May 1;6(1):34. doi: 10.1186/s40478-018-0535-z.

6.

Functional imaging in microfluidic chambers reveals sensory neuron sensitivity is differentially regulated between neuronal regions.

Clark AJ, Menendez G, AlQatari M, Patel N, Arstad E, Schiavo G, Koltzenburg M.

Pain. 2018 Jul;159(7):1413-1425. doi: 10.1097/j.pain.0000000000001145.

PMID:
29419650
7.

A Dual Reporter Iodinated Labeling Reagent for Cancer Positron Emission Tomography Imaging and Fluorescence-Guided Surgery.

Lu Z, Pham TT, Rajkumar V, Yu Z, Pedley RB, Årstad E, Maher J, Yan R.

J Med Chem. 2018 Feb 22;61(4):1636-1645. doi: 10.1021/acs.jmedchem.7b01746. Epub 2018 Feb 6.

8.

Neuroinflammation imaging markers for epileptogenesis.

Koepp MJ, Årstad E, Bankstahl JP, Dedeurwaerdere S, Friedman A, Potschka H, Ravizza T, Theodore WH, Baram TZ.

Epilepsia. 2017 Jul;58 Suppl 3:11-19. doi: 10.1111/epi.13778.

9.

Detecting intratumoral heterogeneity of EGFR activity by liposome-based in vivo transfection of a fluorescent biosensor.

Weitsman G, Mitchell NJ, Evans R, Cheung A, Kalber TL, Bofinger R, Fruhwirth GO, Keppler M, Wright ZVF, Barber PR, Gordon P, de Koning T, Wulaningsih W, Sander K, Vojnovic B, Ameer-Beg S, Lythgoe M, Arnold JN, Årstad E, Festy F, Hailes HC, Tabor AB, Ng T.

Oncogene. 2017 Jun 22;36(25):3618-3628. doi: 10.1038/onc.2016.522. Epub 2017 Feb 6.

10.

Characterization of tau positron emission tomography tracer [18F]AV-1451 binding to postmortem tissue in Alzheimer's disease, primary tauopathies, and other dementias.

Sander K, Lashley T, Gami P, Gendron T, Lythgoe MF, Rohrer JD, Schott JM, Revesz T, Fox NC, Årstad E.

Alzheimers Dement. 2016 Nov;12(11):1116-1124. doi: 10.1016/j.jalz.2016.01.003. Epub 2016 Feb 15.

PMID:
26892233
11.

A dual optical and nuclear imaging reagent for peptide labelling via disulfide bridging.

Fletcher SA, Sin PK, Nobles M, Årstad E, Tinker A, Baker JR.

Org Biomol Chem. 2015 Oct 7;13(37):9559-63. doi: 10.1039/c5ob01468a.

PMID:
26299430
12.

Bimodal Imaging of Inflammation with SPECT/CT and MRI Using Iodine-125 Labeled VCAM-1 Targeting Microparticle Conjugates.

Patel N, Duffy BA, Badar A, Lythgoe MF, Årstad E.

Bioconjug Chem. 2015 Aug 19;26(8):1542-9. doi: 10.1021/acs.bioconjchem.5b00380. Epub 2015 Aug 11.

13.

Development of Fluorine-18 Labeled Metabolically Activated Tracers for Imaging of Drug Efflux Transporters with Positron Emission Tomography.

Sander K, Galante E, Gendron T, Yiannaki E, Patel N, Kalber TL, Badar A, Robson M, Johnson SP, Bauer F, Mairinger S, Stanek J, Wanek T, Kuntner C, Kottke T, Weizel L, Dickens D, Erlandsson K, Hutton BF, Lythgoe MF, Stark H, Langer O, Koepp M, Årstad E.

J Med Chem. 2015 Aug 13;58(15):6058-80. doi: 10.1021/acs.jmedchem.5b00652. Epub 2015 Jul 24.

PMID:
26161456
14.

Significant Therapeutic Efficacy with Combined Radioimmunotherapy and Cetuximab in Preclinical Models of Colorectal Cancer.

Vassileva V, Rajkumar V, Mazzantini M, Robson M, Badar A, Sharma S, Årstad E, Hochhauser D, Lythgoe MF, Kinghorn J, Boxer GM, Pedley RB.

J Nucl Med. 2015 Aug;56(8):1239-45. doi: 10.2967/jnumed.115.157362. Epub 2015 Jun 4. Erratum in: J Nucl Med. 2015 Nov;56(11):1807. Kinghorn, Jane [added].

15.

Sulfonium salts as leaving groups for aromatic labelling of drug-like small molecules with fluorine-18.

Sander K, Gendron T, Yiannaki E, Cybulska K, Kalber TL, Lythgoe MF, Årstad E.

Sci Rep. 2015 Apr 21;5:9941. doi: 10.1038/srep09941.

16.

Fluorescence-guided development of a tricistronic vector encoding bimodal optical and nuclear genetic reporters for in vivo cellular imaging.

Badar A, Kiru L, Kalber TL, Jathoul A, Straathof K, Årstad E, Lythgoe MF, Pule M.

EJNMMI Res. 2015 Mar 28;5:18. doi: 10.1186/s13550-015-0097-z. eCollection 2015.

17.

Preferential targeting of disseminated liver tumors using a recombinant adeno-associated viral vector.

Della Peruta M, Badar A, Rosales C, Chokshi S, Kia A, Nathwani D, Galante E, Yan R, Arstad E, Davidoff AM, Williams R, Lythgoe MF, Nathwani AC.

Hum Gene Ther. 2015 Feb;26(2):94-103. doi: 10.1089/hum.2014.052.

18.

Development of purine-derived 18F-labeled pro-drug tracers for imaging of MRP1 activity with PET.

Galante E, Okamura T, Sander K, Kikuchi T, Okada M, Zhang MR, Robson M, Badar A, Lythgoe M, Koepp M, Årstad E.

J Med Chem. 2014 Feb 13;57(3):1023-32. doi: 10.1021/jm401764a. Epub 2014 Feb 4.

19.

Synthesis and evaluation of a 125I-labeled iminodihydroquinoline-derived tracer for imaging of voltage-gated sodium channels.

Pérez-Medina C, Patel N, Robson M, Lythgoe MF, Arstad E.

Bioorg Med Chem Lett. 2013 Sep 15;23(18):5170-3. doi: 10.1016/j.bmcl.2013.07.014. Epub 2013 Jul 18.

20.

In vivo imaging of glucose uptake and metabolism in tumors.

Walker-Samuel S, Ramasawmy R, Torrealdea F, Rega M, Rajkumar V, Johnson SP, Richardson S, Gonçalves M, Parkes HG, Arstad E, Thomas DL, Pedley RB, Lythgoe MF, Golay X.

Nat Med. 2013 Aug;19(8):1067-72. doi: 10.1038/nm.3252. Epub 2013 Jul 7.

21.

Chelator-accelerated one-pot 'click' labeling of small molecule tracers with 2-[¹⁸F]fluoroethyl azide.

Galante E, Schoultz BW, Koepp M, Arstad E.

Molecules. 2013 May 10;18(5):5335-47. doi: 10.3390/molecules18055335.

22.

Exploration of the structure-activity relationship of a novel tetracyclic class of TSPO ligands-potential novel positron emitting tomography imaging agents.

O'Shea D, Ahmad R, Årstad E, Avory M, Chau WF, Durrant C, Hirani E, Jones PA, Khan I, Luthra SK, Mantzilas D, Morisson-Iveson V, Passmore J, Robins EG, Shan B, Wadsworth H, Walton S, Zhao Y, Trigg W.

Bioorg Med Chem Lett. 2013 Apr 15;23(8):2368-72. doi: 10.1016/j.bmcl.2013.02.057. Epub 2013 Feb 24.

PMID:
23489633
23.

Radiosynthesis of the D2/3 agonist [3-11C]-(+)-PHNO using [11C]iodomethane.

Francisco Garcia-Arguello S, Fortt R, Steel CJ, Brickute D, Glaser M, Turton DR, Robins EG, Arstad E, Luthra SK.

Appl Radiat Isot. 2013 Mar;73:79-83. doi: 10.1016/j.apradiso.2012.11.009. Epub 2012 Nov 23.

PMID:
23291563
24.

A one-pot three-component radiochemical reaction for rapid assembly of 125I-labeled molecular probes.

Yan R, Sander K, Galante E, Rajkumar V, Badar A, Robson M, El-Emir E, Lythgoe MF, Pedley RB, Årstad E.

J Am Chem Soc. 2013 Jan 16;135(2):703-9. doi: 10.1021/ja307926g. Epub 2013 Jan 7.

PMID:
23194416
25.

Evaluation of a 125I-labelled benzazepinone derived voltage-gated sodium channel blocker for imaging with SPECT.

Pérez-Medina C, Patel N, Robson M, Badar A, Lythgoe MF, Årstad E.

Org Biomol Chem. 2012 Dec 21;10(47):9474-80. doi: 10.1039/c2ob26695d. Epub 2012 Nov 2.

PMID:
23117159
26.

One-pot synthesis of an 125I-labeled trifunctional reagent for multiscale imaging with optical and nuclear techniques.

Yan R, El-Emir E, Rajkumar V, Robson M, Jathoul AP, Pedley RB, Årstad E.

Angew Chem Int Ed Engl. 2011 Jul 18;50(30):6793-5. doi: 10.1002/anie.201102072. Epub 2011 Jun 14. No abstract available.

PMID:
21674741
27.

Radiosynthesis and pre-clinical evaluation of [(18)F]fluoro-[1,2-(2)H(4)]choline.

Smith G, Zhao Y, Leyton J, Shan B, Nguyen QD, Perumal M, Turton D, Årstad E, Luthra SK, Robins EG, Aboagye EO.

Nucl Med Biol. 2011 Jan;38(1):39-51. doi: 10.1016/j.nucmedbio.2010.06.012. Epub 2010 Sep 1.

PMID:
21220128
28.

Evaluation of the kappa-opioid receptor-selective tracer [(11)C]GR103545 in awake rhesus macaques.

Schoultz BW, Hjornevik T, Willoch F, Marton J, Noda A, Murakami Y, Miyoshi S, Nishimura S, Arstad E, Drzezga A, Matsunari I, Henriksen G.

Eur J Nucl Med Mol Imaging. 2010 Jun;37(6):1174-80. doi: 10.1007/s00259-010-1384-6. Epub 2010 Feb 16.

PMID:
20157708
29.

Positron emission tomography imaging of drug-induced tumor apoptosis with a caspase-3/7 specific [18F]-labeled isatin sulfonamide.

Nguyen QD, Smith G, Glaser M, Perumal M, Arstad E, Aboagye EO.

Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16375-80. doi: 10.1073/pnas.0901310106. Epub 2009 Sep 3.

30.

Nuclear imaging of molecular processes in cancer.

Torres Martin de Rosales R, Arstad E, Blower PJ.

Target Oncol. 2009 Sep;4(3):183-97. doi: 10.1007/s11523-009-0120-2. Epub 2009 Sep 25. Review. Erratum in: Target Oncol. 2009 Sep;4(3):199.

PMID:
19779864
31.

[18F]fluoromethyl-[1,2-2H4]-choline: a novel radiotracer for imaging choline metabolism in tumors by positron emission tomography.

Leyton J, Smith G, Zhao Y, Perumal M, Nguyen QD, Robins E, Arstad E, Aboagye EO.

Cancer Res. 2009 Oct 1;69(19):7721-8. doi: 10.1158/0008-5472.CAN-09-1419. Epub 2009 Sep 22.

32.

Design, synthesis, and biological characterization of a caspase 3/7 selective isatin labeled with 2-[18F]fluoroethylazide.

Smith G, Glaser M, Perumal M, Nguyen QD, Shan B, Arstad E, Aboagye EO.

J Med Chem. 2008 Dec 25;51(24):8057-67. doi: 10.1021/jm801107u.

PMID:
19049429
33.

Methods for 18F-labeling of RGD peptides: comparison of aminooxy [18F]fluorobenzaldehyde condensation with 'click labeling' using 2-[18F]fluoroethylazide, and S-alkylation with [18F]fluoropropanethiol.

Glaser M, Solbakken M, Turton DR, Pettitt R, Barnett J, Arukwe J, Karlsen H, Cuthbertson A, Luthra SK, Arstad E.

Amino Acids. 2009 Oct;37(4):717-24. doi: 10.1007/s00726-008-0200-0. Epub 2008 Nov 15.

PMID:
19011732
34.

Relationship between ketamine-induced psychotic symptoms and NMDA receptor occupancy: a [(123)I]CNS-1261 SPET study.

Stone JM, Erlandsson K, Arstad E, Squassante L, Teneggi V, Bressan RA, Krystal JH, Ell PJ, Pilowsky LS.

Psychopharmacology (Berl). 2008 Apr;197(3):401-8. doi: 10.1007/s00213-007-1047-x. Epub 2008 Jan 5.

PMID:
18176855
35.

A New Method for Radiosynthesis of C-Labeled Carbamate Groups and its Application for a Highly Efficient Synthesis of the Kappa-Opioid Receptor Tracer [C]GR103545.

Schoultz BW, Arstad E, Marton J, Willoch F, Drzezga A, Wester HJ, Henriksen G.

Open Med Chem J. 2008 Jul 16;2:72-4. doi: 10.2174/1874104500802010072.

36.

Synthesis and reactivity of [18F]-N-fluorobenzenesulfonimide.

Teare H, Robins EG, Arstad E, Luthra SK, Gouverneur V.

Chem Commun (Camb). 2007 Jun 21;(23):2330-2.

PMID:
17844736
37.

"Click labeling" with 2-[18f]fluoroethylazide for positron emission tomography.

Glaser M, Arstad E.

Bioconjug Chem. 2007 May-Jun;18(3):989-93. Epub 2007 Apr 13.

PMID:
17429938
38.

Towards NR2B receptor selective imaging agents for PET-synthesis and evaluation of N-[11C]-(2-methoxy)benzyl (E)-styrene-, 2-naphthyl- and 4-trifluoromethoxyphenylamidine.

Arstad E, Platzer S, Berthele A, Pilowsky LS, Luthra SK, Wester HJ, Henriksen G.

Bioorg Med Chem. 2006 Sep 15;14(18):6307-13. Epub 2006 Jun 13.

PMID:
16777419
39.

[123I]TPCNE--a novel SPET tracer for the sigma-1 receptor: first human studies and in vivo haloperidol challenge.

Stone JM, Arstad E, Erlandsson K, Waterhouse RN, Ell PJ, Pilowsky LS.

Synapse. 2006 Aug;60(2):109-17.

PMID:
16715498
40.

Closing in on the AMPA receptor: synthesis and evaluation of 2-acetyl-1-(4'-chlorophenyl)-6-methoxy-7-[11C]methoxy-1,2,3,4-tetrahydroisoquinoline as a potential PET tracer.

Arstad E, Gitto R, Chimirri A, Caruso R, Constanti A, Turton D, Hume SP, Ahmad R, Pilowsky LS, Luthra SK.

Bioorg Med Chem. 2006 Jul 15;14(14):4712-7. Epub 2006 Apr 18.

PMID:
16621575
41.

Ketamine displaces the novel NMDA receptor SPET probe [(123)I]CNS-1261 in humans in vivo.

Stone JM, Erlandsson K, Arstad E, Bressan RA, Squassante L, Teneggi V, Ell PJ, Pilowsky LS.

Nucl Med Biol. 2006 Feb;33(2):239-43.

PMID:
16546678
43.

ROMPgel-supported triphenylphosphine with potential application in parallel synthesis.

Arstad E, Barrett AG, Hopkins BT, Köbberling J.

Org Lett. 2002 May 30;4(11):1975-7.

PMID:
12027661

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