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Items: 1 to 50 of 192

1.

Endocannabinoid Signaling in Embryonic Neuronal Motility and Cell-Cell Contact - Role of mGluR5 and TRPC3 Channels.

Turunen PM, Louhivuori LM, Louhivuori V, Kukkonen JP, Åkerman KE.

Neuroscience. 2018 Apr 1;375:135-148. doi: 10.1016/j.neuroscience.2018.02.005. Epub 2018 Feb 10.

PMID:
29438802
2.

Regulation of radial glial process growth by glutamate via mGluR5/TRPC3 and neuregulin/ErbB4.

Louhivuori LM, Turunen PM, Louhivuori V, Yellapragada V, Nordström T, Uhlén P, Åkerman KE.

Glia. 2018 Jan;66(1):94-107. doi: 10.1002/glia.23230. Epub 2017 Sep 9.

PMID:
28887860
3.
4.

Calpain Activity Is Essential for ATP-Driven Unconventional Vesicle-Mediated Protein Secretion and Inflammasome Activation in Human Macrophages.

Välimäki E, Cypryk W, Virkanen J, Nurmi K, Turunen PM, Eklund KK, Åkerman KE, Nyman TA, Matikainen S.

J Immunol. 2016 Oct 15;197(8):3315-3325. Epub 2016 Sep 16.

5.

Transient receptor potential channels and their role in modulating radial glial-neuronal interaction: a signaling pathway involving mGluR5.

Louhivuori LM, Jansson L, Turunen PM, Jäntti MH, Nordström T, Louhivuori V, Åkerman KE.

Stem Cells Dev. 2015 Mar 15;24(6):701-13. doi: 10.1089/scd.2014.0209. Epub 2014 Dec 17.

6.

The role of glutamate and its receptors in the proliferation, migration, differentiation and survival of neural progenitor cells.

Jansson LC, Åkerman KE.

J Neural Transm (Vienna). 2014 Aug;121(8):819-36. doi: 10.1007/s00702-014-1174-6. Epub 2014 Feb 23. Review.

PMID:
24562403
7.

Enhanced early expression of membrane receptors with the Rous sarcoma virus promoter in baculovirus-infected insect cells.

Näreoja K, Akerman KE, Näsman J.

Biotechnol Appl Biochem. 2012 Jul-Aug;59(4):314-21. doi: 10.1002/bab.1029. Epub 2012 Jul 26.

PMID:
23586865
8.

Extracellular acidosis is a novel danger signal alerting innate immunity via the NLRP3 inflammasome.

Rajamäki K, Nordström T, Nurmi K, Åkerman KE, Kovanen PT, Öörni K, Eklund KK.

J Biol Chem. 2013 May 10;288(19):13410-9. doi: 10.1074/jbc.M112.426254. Epub 2013 Mar 25.

9.

Effect of glutamate receptor antagonists on migrating neural progenitor cells.

Jansson LC, Louhivuori L, Wigren HK, Nordström T, Louhivuori V, Castrén ML, Åkerman KE.

Eur J Neurosci. 2013 May;37(9):1369-82. doi: 10.1111/ejn.12152. Epub 2013 Feb 6.

PMID:
23383979
10.

Role of low voltage activated calcium channels in neuritogenesis and active migration of embryonic neural progenitor cells.

Louhivuori LM, Louhivuori V, Wigren HK, Hakala E, Jansson LC, Nordström T, Castrén ML, Akerman KE.

Stem Cells Dev. 2013 Apr 15;22(8):1206-19. doi: 10.1089/scd.2012.0234. Epub 2013 Feb 19.

PMID:
23234460
11.

Brain-derived neurotrophic factor increases the motility of a particular N-methyl-D-aspartate /GABA-responsive subset of neural progenitor cells.

Jansson LC, Louhivuori L, Wigren HK, Nordström T, Louhivuori V, Castrén ML, Åkerman KE.

Neuroscience. 2012 Nov 8;224:223-34. doi: 10.1016/j.neuroscience.2012.08.038. Epub 2012 Aug 23.

PMID:
22922352
12.

Effects of acute hypoxia/acidosis on intracellular pH in differentiating neural progenitor cells.

Nordström T, Jansson LC, Louhivuori LM, Akerman KE.

Brain Res. 2012 Jun 21;1461:10-23. doi: 10.1016/j.brainres.2012.04.043. Epub 2012 Apr 28.

PMID:
22608071
13.

Glycosylphosphatidylinositol (GPI)-anchoring of mamba toxins enables cell-restricted receptor silencing.

Näreoja K, Louhivuori LM, Akerman KE, Meriluoto J, Näsman J.

Biochem Biophys Res Commun. 2012 Jan 6;417(1):93-7. doi: 10.1016/j.bbrc.2011.11.062. Epub 2011 Nov 19.

PMID:
22138651
14.

Inhibiting TRPA1 ion channel reduces loss of cutaneous nerve fiber function in diabetic animals: sustained activation of the TRPA1 channel contributes to the pathogenesis of peripheral diabetic neuropathy.

Koivisto A, Hukkanen M, Saarnilehto M, Chapman H, Kuokkanen K, Wei H, Viisanen H, Akerman KE, Lindstedt K, Pertovaara A.

Pharmacol Res. 2012 Jan;65(1):149-58. doi: 10.1016/j.phrs.2011.10.006. Epub 2011 Nov 23.

PMID:
22133672
15.

Functional α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors in differentiating embryonic neural progenitor cells.

Jansson LC, Wigren HK, Nordström T, Akerman KE.

Neuroreport. 2011 Apr 20;22(6):282-7. doi: 10.1097/WNR.0b013e3283457b34.

PMID:
21399551
16.

BDNF and TrkB in neuronal differentiation of Fmr1-knockout mouse.

Louhivuori V, Vicario A, Uutela M, Rantamäki T, Louhivuori LM, Castrén E, Tongiorgi E, Akerman KE, Castrén ML.

Neurobiol Dis. 2011 Feb;41(2):469-80. doi: 10.1016/j.nbd.2010.10.018. Epub 2010 Nov 1.

PMID:
21047554
17.

Selective interference with TRPC3/6 channels disrupts OX1 receptor signalling via NCX and reveals a distinct calcium influx pathway.

Louhivuori LM, Jansson L, Nordström T, Bart G, Näsman J, Akerman KE.

Cell Calcium. 2010 Aug-Sep;48(2-3):114-23. doi: 10.1016/j.ceca.2010.07.005. Epub 2010 Aug 21.

PMID:
20728215
18.

A role for PKD1 and PKD3 activation in modulation of calcium oscillations induced by orexin receptor 1 stimulation.

Peltonen HM, Akerman KE, Bart G.

Biochim Biophys Acta. 2010 Oct;1803(10):1206-12. doi: 10.1016/j.bbamcr.2010.07.001. Epub 2010 Jul 16.

19.

Altered calcium signaling in an experimental model of glaucoma.

Niittykoski M, Kalesnykas G, Larsson KP, Kaarniranta K, Akerman KE, Uusitalo H.

Invest Ophthalmol Vis Sci. 2010 Dec;51(12):6387-93. doi: 10.1167/iovs.09-3816. Epub 2010 Jun 30.

PMID:
20592232
20.

Differentiation dependent expression of TRPA1 and TRPM8 channels in IMR-32 human neuroblastoma cells.

Louhivuori LM, Bart G, Larsson KP, Louhivuori V, Näsman J, Nordström T, Koivisto AP, Akerman KE.

J Cell Physiol. 2009 Oct;221(1):67-74. doi: 10.1002/jcp.21828.

PMID:
19507192
21.

Involvement of TRPC3 channels in calcium oscillations mediated by OX(1) orexin receptors.

Peltonen HM, Magga JM, Bart G, Turunen PM, Antikainen MS, Kukkonen JP, Akerman KE.

Biochem Biophys Res Commun. 2009 Jul 31;385(3):408-12. doi: 10.1016/j.bbrc.2009.05.077. Epub 2009 May 21.

PMID:
19464259
22.

Neurotransmitter responsiveness during early maturation of neural progenitor cells.

Kärkkäinen V, Louhivuori V, Castrén ML, Akerman KE.

Differentiation. 2009 Feb;77(2):188-98. doi: 10.1016/j.diff.2008.10.005. Epub 2008 Nov 18.

PMID:
19281779
23.

Measurement of chloride movement in neuronal preparations.

Schwartz-Bloom RD, Engblom AC, Akerman KE, Inglefield JR.

Curr Protoc Neurosci. 2001 May;Chapter 7:Unit7.10. doi: 10.1002/0471142301.ns0710s04.

PMID:
18428521
24.

Food-induced expression of orexin receptors in rat duodenal mucosa regulates the bicarbonate secretory response to orexin-A.

Bengtsson MW, Mäkelä K, Sjöblom M, Uotila S, Akerman KE, Herzig KH, Flemström G.

Am J Physiol Gastrointest Liver Physiol. 2007 Aug;293(2):G501-9. Epub 2007 Jun 21.

25.

The orexin OX1 receptor regulates Ca2+ entry via diacylglycerol-activated channels in differentiated neuroblastoma cells.

Näsman J, Bart G, Larsson K, Louhivuori L, Peltonen H, Akerman KE.

J Neurosci. 2006 Oct 18;26(42):10658-66.

26.

Agonist potency differentiates G protein activation and Ca2+ signalling by the orexin receptor type 1.

Magga J, Bart G, Oker-Blom C, Kukkonen JP, Akerman KE, Näsman J.

Biochem Pharmacol. 2006 Mar 14;71(6):827-36. Epub 2006 Jan 20.

PMID:
16430869
27.

G-protein-coupled OX1 orexin/hcrtr-1 hypocretin receptors induce caspase-dependent and -independent cell death through p38 mitogen-/stress-activated protein kinase.

Ammoun S, Lindholm D, Wootz H, Akerman KE, Kukkonen JP.

J Biol Chem. 2006 Jan 13;281(2):834-42. Epub 2005 Nov 10.

28.

OX1 orexin receptors activate extracellular signal-regulated kinase in Chinese hamster ovary cells via multiple mechanisms: the role of Ca2+ influx in OX1 receptor signaling.

Ammoun S, Johansson L, Ekholm ME, Holmqvist T, Danis AS, Korhonen L, Sergeeva OA, Haas HL, Akerman KE, Kukkonen JP.

Mol Endocrinol. 2006 Jan;20(1):80-99. Epub 2005 Sep 1.

PMID:
16141359
29.

Pharmacology of stomoxytachykinin receptor depends on second messenger system.

Poels J, Nachman RJ, Akerman KE, Oonk HB, Guerrero F, De Loof A, Janecka AE, Torfs H, Vanden Broeck J.

Peptides. 2005 Jan;26(1):109-14.

PMID:
15626510
30.

OX1 orexin receptors couple to adenylyl cyclase regulation via multiple mechanisms.

Holmqvist T, Johansson L, Ostman M, Ammoun S, Akerman KE, Kukkonen JP.

J Biol Chem. 2005 Feb 25;280(8):6570-9. Epub 2004 Dec 16.

31.

PC12 and HEL cell communication in a reconstituted synapse analyzed with mathematical modeling.

Krjukova J, Mirtov V, Akerman KE.

Neurochem Int. 2005 Jan;46(1):83-91.

PMID:
15567518
32.

Orexin-A-induced Ca2+ entry: evidence for involvement of trpc channels and protein kinase C regulation.

Larsson KP, Peltonen HM, Bart G, Louhivuori LM, Penttonen A, Antikainen M, Kukkonen JP, Akerman KE.

J Biol Chem. 2005 Jan 21;280(3):1771-81. Epub 2004 Nov 10.

33.

Muscarinic toxin 7 selectivity is dictated by extracellular receptor loops.

Kukkonen A, Peräkylä M, Akerman KE, Näsman J.

J Biol Chem. 2004 Dec 3;279(49):50923-9. Epub 2004 Sep 27.

34.

Ca2+-dependent potentiation of muscarinic receptor-mediated Ca2+ elevation.

Akerman KE, Shariatmadari R, Krjukova J, Larsson KP, Courtney MJ, Kukkonen JP.

Cell Calcium. 2004 Nov;36(5):397-408.

PMID:
15451623
35.

Phospholipase C activator m-3M3FBS affects Ca2+ homeostasis independently of phospholipase C activation.

Krjukova J, Holmqvist T, Danis AS, Akerman KE, Kukkonen JP.

Br J Pharmacol. 2004 Sep;143(1):3-7. Epub 2004 Aug 9.

36.

Substitution of conserved glycine residue by alanine in natural and synthetic neuropeptide ligands causes partial agonism at the stomoxytachykinin receptor.

Poels J, Van Loy T, Franssens V, Detheux M, Nachman RJ, Oonk HB, Akerman KE, Vassart G, Parmentier M, De Loof A, Torfs H, Broeck JV.

J Neurochem. 2004 Jul;90(2):472-8.

37.

Characterization of M2 muscarinic receptor activation of different G protein subtypes.

Uustare A, Näsman J, Akerman KE, Rinken A.

Neurochem Int. 2004 Jan;44(2):119-24.

PMID:
12971914
38.

The STC-1 cells express functional orexin-A receptors coupled to CCK release.

Larsson KP, Akerman KE, Magga J, Uotila S, Kukkonen JP, Näsman J, Herzig KH.

Biochem Biophys Res Commun. 2003 Sep 12;309(1):209-16.

PMID:
12943684
39.

Prevention of NMDA-induced death of cortical neurons by inhibition of protein kinase Czeta.

Koponen S, Kurkinen K, Akerman KE, Mochly-Rosen D, Chan PH, Koistinaho J.

J Neurochem. 2003 Jul;86(2):442-50.

40.

Short fasting dramatically decreases rat duodenal secretory responsiveness to orexin A but not to VIP or melatonin.

Flemström G, Sjöblom M, Jedstedt G, Akerman KE.

Am J Physiol Gastrointest Liver Physiol. 2003 Dec;285(6):G1091-6. Epub 2003 Jul 17.

41.

Distinct recognition of OX1 and OX2 receptors by orexin peptides.

Ammoun S, Holmqvist T, Shariatmadari R, Oonk HB, Detheux M, Parmentier M, Akerman KE, Kukkonen JP.

J Pharmacol Exp Ther. 2003 May;305(2):507-14. Epub 2003 Jan 24.

42.

Different roles for Gi and Go proteins in modulation of adenylyl cyclase type-2 activity.

Näsman J, Kukkonen JP, Holmqvist T, Akerman KE.

J Neurochem. 2002 Dec;83(6):1252-61.

43.

Functional analysis of synthetic insectatachykinin analogs on recombinant neurokinin receptor expressing cell lines.

Torfs H, Akerman KE, Nachman RJ, Oonk HB, Detheux M, Poels J, Loy TV, Loof AD, Meloen RH, Vassart G, Parmentier M, Broeck JV.

Peptides. 2002 Nov;23(11):1999-2005.

PMID:
12431738
44.

Functions of the orexinergic/hypocretinergic system.

Kukkonen JP, Holmqvist T, Ammoun S, Akerman KE.

Am J Physiol Cell Physiol. 2002 Dec;283(6):C1567-91. Review. Erratum in: Am J Physiol Cell Physiol. 2003 Apr;284(4):following table of contents.

45.

Orexin signaling in recombinant neuron-like cells.

Holmqvist T, Akerman KE, Kukkonen JP.

FEBS Lett. 2002 Aug 28;526(1-3):11-4.

46.

Regulation of TRKB surface expression by brain-derived neurotrophic factor and truncated TRKB isoforms.

Haapasalo A, Sipola I, Larsson K, Akerman KE, Stoilov P, Stamm S, Wong G, Castren E.

J Biol Chem. 2002 Nov 8;277(45):43160-7. Epub 2002 Aug 28.

47.

Mechanisms of nicotine mediated communication between NGF-differentiated PC12 and HEL cells.

Krjukova J, Akerman KE.

Neuroreport. 2002 Jul 2;13(9):1157-61.

PMID:
12151760
48.

Contribution of glycolytic and mitochondrial pathways in glucose-induced changes in islet respiration and insulin secretion.

Ortsäter H, Liss P, Akerman KE, Bergsten P.

Pflugers Arch. 2002 Jul;444(4):506-12. Epub 2002 Jun 8.

PMID:
12136270
49.

Cloning, structural characterization and functional expression of a zebrafish bradykinin B2-related receptor.

Dunér T, Conlon JM, Kukkonen JP, Akerman KE, Yan YL, Postlethwait JH, Larhammar D.

Biochem J. 2002 Jun 15;364(Pt 3):817-24.

50.

Analysis of C-terminally substituted tachykinin-like peptide agonists by means of aequorin-based luminescent assays for human and insect neurokinin receptors.

Torfs H, Detheux M, Oonk HB, Akerman KE, Poels J, Van Loy T, De Loof A, Vassart G, Parmentier M, Vanden Broeck J.

Biochem Pharmacol. 2002 May 1;63(9):1675-82.

PMID:
12007570

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