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Items: 1 to 20 of 99

1.

Inhibiting the stringent response blocks Mycobacterium tuberculosis entry into quiescence and reduces persistence.

Dutta NK, Klinkenberg LG, Vazquez MJ, Segura-Carro D, Colmenarejo G, Ramon F, Rodriguez-Miquel B, Mata-Cantero L, Porras-De Francisco E, Chuang YM, Rubin H, Lee JJ, Eoh H, Bader JS, Perez-Herran E, Mendoza-Losana A, Karakousis PC.

Sci Adv. 2019 Mar 20;5(3):eaav2104. doi: 10.1126/sciadv.aav2104. eCollection 2019 Mar.

2.

Remembering the Host in Tuberculosis Drug Development.

Frank DJ, Horne DJ, Dutta NK, Shaku MT, Madensein R, Hawn TR, Steyn AJC, Karakousis PC, Kana BD, Meintjes G, Laughon B, Tanvir Z.

J Infect Dis. 2019 Apr 19;219(10):1518-1524. doi: 10.1093/infdis/jiy712.

PMID:
30590592
3.

Transcriptional Approach for Decoding the Mechanism of rpoC Compensatory Mutations for the Fitness Cost in Rifampicin-Resistant Mycobacterium tuberculosis.

Xu Z, Zhou A, Wu J, Zhou A, Li J, Zhang S, Wu W, Karakousis PC, Yao YF.

Front Microbiol. 2018 Nov 30;9:2895. doi: 10.3389/fmicb.2018.02895. eCollection 2018.

4.

Genome analysis of Mycobacterium avium subspecies hominissuis strain 109.

Matern WM, Bader JS, Karakousis PC.

Sci Data. 2018 Dec 4;5:180277. doi: 10.1038/sdata.2018.277.

5.

Unprecedented in Vitro Antitubercular Activitiy of Manganese(II) Complexes Containing 1,10-Phenanthroline and Dicarboxylate Ligands: Increased Activity, Superior Selectivity, and Lower Toxicity in Comparison to Their Copper(II) Analogs.

McCarron P, McCann M, Devereux M, Kavanagh K, Skerry C, Karakousis PC, Aor AC, Mello TP, Santos ALS, Campos DL, Pavan FR.

Front Microbiol. 2018 Jul 2;9:1432. doi: 10.3389/fmicb.2018.01432. eCollection 2018.

6.

Gene Enrichment Analysis Reveals Major Regulators of Mycobacterium tuberculosis Gene Expression in Two Models of Antibiotic Tolerance.

Matern WM, Rifat D, Bader JS, Karakousis PC.

Front Microbiol. 2018 Apr 4;9:610. doi: 10.3389/fmicb.2018.00610. eCollection 2018.

7.

Altered Mycobacterium tuberculosis Cell Wall Metabolism and Physiology Associated With RpoB Mutation H526D.

Campodónico VL, Rifat D, Chuang YM, Ioerger TR, Karakousis PC.

Front Microbiol. 2018 Mar 19;9:494. doi: 10.3389/fmicb.2018.00494. eCollection 2018.

8.

Intranasal Immunization with DnaK Protein Induces Protective Mucosal Immunity against Tuberculosis in CD4-Depleted Mice.

Chuang YM, Pinn ML, Karakousis PC, Hung CF.

Front Cell Infect Microbiol. 2018 Feb 8;8:31. doi: 10.3389/fcimb.2018.00031. eCollection 2018.

9.

Erratum for Dutta et al., "Metformin Adjunctive Therapy Does Not Improve the Sterilizing Activity of the First-Line Antitubercular Regimen in Mice".

Dutta NK, Pinn ML, Karakousis PC.

Antimicrob Agents Chemother. 2018 Jan 25;62(2). pii: e02493-17. doi: 10.1128/AAC.02493-17. Print 2018 Feb. No abstract available.

10.

Metformin Use Reverses the Increased Mortality Associated With Diabetes Mellitus During Tuberculosis Treatment.

Degner NR, Wang JY, Golub JE, Karakousis PC.

Clin Infect Dis. 2018 Jan 6;66(2):198-205. doi: 10.1093/cid/cix819.

11.

Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13.

Aggarwal A, Parai MK, Shetty N, Wallis D, Woolhiser L, Hastings C, Dutta NK, Galaviz S, Dhakal RC, Shrestha R, Wakabayashi S, Walpole C, Matthews D, Floyd D, Scullion P, Riley J, Epemolu O, Norval S, Snavely T, Robertson GT, Rubin EJ, Ioerger TR, Sirgel FA, van der Merwe R, van Helden PD, Keller P, Böttger EC, Karakousis PC, Lenaerts AJ, Sacchettini JC.

Cell. 2017 Jul 13;170(2):249-259.e25. doi: 10.1016/j.cell.2017.06.025. Epub 2017 Jun 29.

12.

Metformin Adjunctive Therapy Does Not Improve the Sterilizing Activity of the First-Line Antitubercular Regimen in Mice.

Dutta NK, Pinn ML, Karakousis PC.

Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e00652-17. doi: 10.1128/AAC.00652-17. Print 2017 Aug. Erratum in: Antimicrob Agents Chemother. 2018 Jan 25;62(2):.

13.

In vitro and in vivo fitness costs associated with Mycobacterium tuberculosis RpoB mutation H526D.

Rifat D, Campodónico VL, Tao J, Miller JA, Alp A, Yao Y, Karakousis PC.

Future Microbiol. 2017 Jul;12:753-765. doi: 10.2217/fmb-2017-0022. Epub 2017 Mar 27.

14.

Empirical Antifungal Therapy in Critically Ill Patients With Sepsis: Another Case of Less Is More in the ICU.

Siddharthan T, Karakousis PC, Checkley W.

JAMA. 2016 Oct 18;316(15):1549-1550. doi: 10.1001/jama.2016.13801. No abstract available.

PMID:
27706463
15.

Stringent Response Factors PPX1 and PPK2 Play an Important Role in Mycobacterium tuberculosis Metabolism, Biofilm Formation, and Sensitivity to Isoniazid In Vivo.

Chuang YM, Dutta NK, Hung CF, Wu TC, Rubin H, Karakousis PC.

Antimicrob Agents Chemother. 2016 Oct 21;60(11):6460-6470. doi: 10.1128/AAC.01139-16. Print 2016 Nov.

16.

Mycobacterial Protein Tyrosine Phosphatases A and B Inhibitors Augment the Bactericidal Activity of the Standard Anti-tuberculosis Regimen.

Dutta NK, He R, Pinn ML, He Y, Burrows F, Zhang ZY, Karakousis PC.

ACS Infect Dis. 2016 Mar 11;2(3):231-239. Epub 2015 Dec 24.

17.

First Evaluation of GenoType MTBDRplus 2.0 Performed Directly on Respiratory Specimens in Central America.

Lanzas F, Ioerger TR, Shah H, Acosta W, Karakousis PC.

J Clin Microbiol. 2016 Oct;54(10):2498-502. doi: 10.1128/JCM.01196-16. Epub 2016 Jul 20.

18.

Identification of a Transcription Factor That Regulates Host Cell Exit and Virulence of Mycobacterium tuberculosis.

Srinivasan L, Gurses SA, Hurley BE, Miller JL, Karakousis PC, Briken V.

PLoS Pathog. 2016 May 18;12(5):e1005652. doi: 10.1371/journal.ppat.1005652. eCollection 2016 May.

19.

Statin adjunctive therapy shortens the duration of TB treatment in mice.

Dutta NK, Bruiners N, Pinn ML, Zimmerman MD, Prideaux B, Dartois V, Gennaro ML, Karakousis PC.

J Antimicrob Chemother. 2016 Jun;71(6):1570-7. doi: 10.1093/jac/dkw014. Epub 2016 Feb 21.

20.

TLR2-Modulating Lipoproteins of the Mycobacterium tuberculosis Complex Enhance the HIV Infectivity of CD4+ T Cells.

Skerry C, Klinkenberg LG, Page KR, Karakousis PC.

PLoS One. 2016 Jan 25;11(1):e0147192. doi: 10.1371/journal.pone.0147192. eCollection 2016.

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