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Items: 1 to 20 of 180


A new experimental platform facilitates assessment of the transcriptional and chromatin landscapes of aging yeast.

Hendrickson DG, Soifer I, Wranik BJ, Kim G, Robles M, Gibney PA, McIsaac RS.

Elife. 2018 Oct 18;7. pii: e39911. doi: 10.7554/eLife.39911. [Epub ahead of print]


Electron microscopy of Chaetomium pom152 shows the assembly of ten-bead string.

Hao Q, Zhang B, Yuan K, Shi H, Blobel G.

Cell Discov. 2018 Sep 18;4:56. doi: 10.1038/s41421-018-0057-7. eCollection 2018. No abstract available.


A Promising Small Molecule for Vanishing White Matter Disease.

Mithal DS, Rubin JP.

Pediatr Neurol Briefs. 2018 Aug 28;32:5. doi: 10.15844/pedneurbriefs-32-5.


An open-source platform for analyzing and sharing worm-behavior data.

Javer A, Currie M, Lee CW, Hokanson J, Li K, Martineau CN, Yemini E, Grundy LJ, Li C, Ch'ng Q, Schafer WR, Nollen EAA, Kerr R, Brown AEX.

Nat Methods. 2018 Sep;15(9):645-646. doi: 10.1038/s41592-018-0112-1. No abstract available.


Enhancer Activity Requires CBP/P300 Bromodomain-Dependent Histone H3K27 Acetylation.

Raisner R, Kharbanda S, Jin L, Jeng E, Chan E, Merchant M, Haverty PM, Bainer R, Cheung T, Arnott D, Flynn EM, Romero FA, Magnuson S, Gascoigne KE.

Cell Rep. 2018 Aug 14;24(7):1722-1729. doi: 10.1016/j.celrep.2018.07.041.


The future of humans as model organisms.

FitzGerald G, Botstein D, Califf R, Collins R, Peters K, Van Bruggen N, Rader D.

Science. 2018 Aug 10;361(6402):552-553. doi: 10.1126/science.aau7779. No abstract available.


Ablation of PM20D1 reveals N-acyl amino acid control of metabolism and nociception.

Long JZ, Roche AM, Berdan CA, Louie SM, Roberts AJ, Svensson KJ, Dou FY, Bateman LA, Mina AI, Deng Z, Jedrychowski MP, Lin H, Kamenecka TM, Asara JM, Griffin PR, Banks AS, Nomura DK, Spiegelman BM.

Proc Natl Acad Sci U S A. 2018 Jul 17;115(29):E6937-E6945. doi: 10.1073/pnas.1803389115. Epub 2018 Jul 2.


A CRISPR screen identifies MAPK7 as a target for combination with MEK inhibition in KRAS mutant NSCLC.

Dompe N, Klijn C, Watson SA, Leng K, Port J, Cuellar T, Watanabe C, Haley B, Neve R, Evangelista M, Stokoe D.

PLoS One. 2018 Jun 18;13(6):e0199264. doi: 10.1371/journal.pone.0199264. eCollection 2018.


Correction to: A window into extreme longevity; the circulating metabolomic signature of the naked mole-rat, a mammal that shows negligible senescence.

Lewis KN, Rubinstein ND, Buffenstein R.

Geroscience. 2018 Jun;40(3):357-358. doi: 10.1007/s11357-018-0023-1.


Analysis of gene expression profiles of multiple skin diseases identifies a conserved signature of disrupted homeostasis.

Mills KJ, Robinson MK, Sherrill JD, Schnell DJ, Xu J.

Exp Dermatol. 2018 Sep;27(9):1000-1008. doi: 10.1111/exd.13694. Epub 2018 Jul 30.


A window into extreme longevity; the circulating metabolomic signature of the naked mole-rat, a mammal that shows negligible senescence.

Lewis KN, Rubinstein ND, Buffenstein R.

Geroscience. 2018 Apr;40(2):105-121. doi: 10.1007/s11357-018-0014-2. Epub 2018 Apr 20. Erratum in: Geroscience. 2018 May 31;:.


Neonatal care practices in sub-Saharan Africa: a systematic review of quantitative and qualitative data.

Bee M, Shiroor A, Hill Z.

J Health Popul Nutr. 2018 Apr 16;37(1):9. doi: 10.1186/s41043-018-0141-5. Review.


Behavioral Variability and Phenotypic Diversity in Bacterial Chemotaxis.

Waite AJ, Frankel NW, Emonet T.

Annu Rev Biophys. 2018 May 20;47:595-616. doi: 10.1146/annurev-biophys-062215-010954. Epub 2018 Apr 4.


Sequential regulatory activity prediction across chromosomes with convolutional neural networks.

Kelley DR, Reshef YA, Bileschi M, Belanger D, McLean CY, Snoek J.

Genome Res. 2018 May;28(5):739-750. doi: 10.1101/gr.227819.117. Epub 2018 Mar 27.


The small molecule ISRIB rescues the stability and activity of Vanishing White Matter Disease eIF2B mutant complexes.

Wong YL, LeBon L, Edalji R, Lim HB, Sun C, Sidrauski C.

Elife. 2018 Feb 28;7. pii: e32733. doi: 10.7554/eLife.32733.


Common and divergent features of galactose-1-phosphate and fructose-1-phosphate toxicity in yeast.

Gibney PA, Schieler A, Chen JC, Bacha-Hummel JM, Botstein M, Volpe M, Silverman SJ, Xu Y, Bennett BD, Rabinowitz JD, Botstein D.

Mol Biol Cell. 2018 Apr 15;29(8):897-910. doi: 10.1091/mbc.E17-11-0666. Epub 2018 Mar 30.


Challenges in validating candidate therapeutic targets in cancer.

Settleman J, Sawyers CL, Hunter T.

Elife. 2018 Feb 8;7. pii: e32402. doi: 10.7554/eLife.32402.


Dynamic Ligand Discrimination in the Notch Signaling Pathway.

Nandagopal N, Santat LA, LeBon L, Sprinzak D, Bronner ME, Elowitz MB.

Cell. 2018 Feb 8;172(4):869-880.e19. doi: 10.1016/j.cell.2018.01.002. Epub 2018 Feb 1.


Naked Mole-Rat mortality rates defy gompertzian laws by not increasing with age.

Ruby JG, Smith M, Buffenstein R.

Elife. 2018 Jan 24;7. pii: e31157. doi: 10.7554/eLife.31157.


Lipid Homeostasis Is Maintained by Dual Targeting of the Mitochondrial PE Biosynthesis Enzyme to the ER.

Friedman JR, Kannan M, Toulmay A, Jan CH, Weissman JS, Prinz WA, Nunnari J.

Dev Cell. 2018 Jan 22;44(2):261-270.e6. doi: 10.1016/j.devcel.2017.11.023. Epub 2017 Dec 28.


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