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Items: 1 to 20 of 71

1.

Novel interaction between Alzheimer's disease-related protein presenilin 1 and glutamate transporter 1.

Zoltowska KM, Maesako M, Meier J, Berezovska O.

Sci Rep. 2018 Jun 7;8(1):8718. doi: 10.1038/s41598-018-26888-2.

2.

Selective plane illumination microscopy (SPIM) with time-domain fluorescence lifetime imaging microscopy (FLIM) for volumetric measurement of cleared mouse brain samples.

Funane T, Hou SS, Zoltowska KM, van Veluw SJ, Berezovska O, Kumar ATN, Bacskai BJ.

Rev Sci Instrum. 2018 May;89(5):053705. doi: 10.1063/1.5018846.

PMID:
29864842
3.

Soluble Gamma-secretase Modulators Attenuate Alzheimer's β-amyloid Pathology and Induce Conformational Changes in Presenilin 1.

Raven F, Ward JF, Zoltowska KM, Wan Y, Bylykbashi E, Miller SJ, Shen X, Choi SH, Rynearson KD, Berezovska O, Wagner SL, Tanzi RE, Zhang C.

EBioMedicine. 2017 Oct;24:93-101. doi: 10.1016/j.ebiom.2017.08.028. Epub 2017 Sep 4.

4.

Isoform- and cell type-specific structure of apolipoprotein E lipoparticles as revealed by a novel Forster resonance energy transfer assay.

Kara E, Marks JD, Fan Z, Klickstein JA, Roe AD, Krogh KA, Wegmann S, Maesako M, Luo CC, Mylvaganam R, Berezovska O, Hudry E, Hyman BT.

J Biol Chem. 2017 Sep 8;292(36):14720-14729. doi: 10.1074/jbc.M117.784264. Epub 2017 Jul 6.

5.

Dynamic Nature of presenilin1/γ-Secretase: Implication for Alzheimer's Disease Pathogenesis.

Zoltowska KM, Berezovska O.

Mol Neurobiol. 2018 Mar;55(3):2275-2284. doi: 10.1007/s12035-017-0487-5. Epub 2017 Mar 22. Review.

PMID:
28332150
6.

Dynamic presenilin 1 and synaptotagmin 1 interaction modulates exocytosis and amyloid β production.

Zoltowska KM, Maesako M, Lushnikova I, Takeda S, Keller LJ, Skibo G, Hyman BT, Berezovska O.

Mol Neurodegener. 2017 Feb 13;12(1):15. doi: 10.1186/s13024-017-0159-y.

7.

Pathogenic PS1 phosphorylation at Ser367.

Maesako M, Horlacher J, Zoltowska KM, Kastanenka KV, Kara E, Svirsky S, Keller LJ, Li X, Hyman BT, Bacskai BJ, Berezovska O.

Elife. 2017 Jan 30;6. pii: e19720. doi: 10.7554/eLife.19720.

8.

Interrelationship between Changes in the Amyloid β 42/40 Ratio and Presenilin 1 Conformation.

Zoltowska KM, Maesako M, Berezovska O.

Mol Med. 2016 Sep;22:329-337. doi: 10.2119/molmed.2016.00127. Epub 2016 Jul 5.

9.

Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta.

Kuzuya A, Zoltowska KM, Post KL, Arimon M, Li X, Svirsky S, Maesako M, Muzikansky A, Gautam V, Kovacs D, Hyman BT, Berezovska O.

BMC Biol. 2016 Mar 31;14:25. doi: 10.1186/s12915-016-0248-3.

10.

Synaptotagmins interact with APP and promote Aβ generation.

Gautam V, D'Avanzo C, Berezovska O, Tanzi RE, Kovacs DM.

Mol Neurodegener. 2015 Jul 23;10:31. doi: 10.1186/s13024-015-0028-5.

11.

Oxidative stress and lipid peroxidation are upstream of amyloid pathology.

Arimon M, Takeda S, Post KL, Svirsky S, Hyman BT, Berezovska O.

Neurobiol Dis. 2015 Dec;84:109-19. doi: 10.1016/j.nbd.2015.06.013. Epub 2015 Jun 21.

12.

The dynamic conformational landscape of gamma-secretase.

Elad N, De Strooper B, Lismont S, Hagen W, Veugelen S, Arimon M, Horré K, Berezovska O, Sachse C, Chávez-Gutiérrez L.

J Cell Sci. 2015 Feb 1;128(3):589-98.

13.

Convergence of pathology in dementia with Lewy bodies and Alzheimer's disease: a role for the novel interaction of alpha-synuclein and presenilin 1 in disease.

Winslow AR, Moussaud S, Zhu L, Post KL, Dickson DW, Berezovska O, McLean PJ.

Brain. 2014 Jul;137(Pt 7):1958-70. doi: 10.1093/brain/awu119. Epub 2014 May 24. Erratum in: Brain. 2014 Nov;137(Pt 11):307. Post, Katherine L [corrected to Post, Kathryn L].

14.

Structural interactions between inhibitor and substrate docking sites give insight into mechanisms of human PS1 complexes.

Li Y, Lu SH, Tsai CJ, Bohm C, Qamar S, Dodd RB, Meadows W, Jeon A, McLeod A, Chen F, Arimon M, Berezovska O, Hyman BT, Tomita T, Iwatsubo T, Johnson CM, Farrer LA, Schmitt-Ulms G, Fraser PE, St George-Hyslop PH.

Structure. 2014 Jan 7;22(1):125-35. doi: 10.1016/j.str.2013.09.018. Epub 2013 Nov 7.

15.

MeCP2: a novel Huntingtin interactor.

McFarland KN, Huizenga MN, Darnell SB, Sangrey GR, Berezovska O, Cha JH, Outeiro TF, Sadri-Vakili G.

Hum Mol Genet. 2014 Feb 15;23(4):1036-44. doi: 10.1093/hmg/ddt499. Epub 2013 Oct 8.

16.

Presenilin-1 adopts pathogenic conformation in normal aging and in sporadic Alzheimer's disease.

Wahlster L, Arimon M, Nasser-Ghodsi N, Post KL, Serrano-Pozo A, Uemura K, Berezovska O.

Acta Neuropathol. 2013 Feb;125(2):187-99. doi: 10.1007/s00401-012-1065-6. Epub 2012 Nov 9.

17.

Neuronal activity and secreted amyloid β lead to altered amyloid β precursor protein and presenilin 1 interactions.

Li X, Uemura K, Hashimoto T, Nasser-Ghodsi N, Arimon M, Lill CM, Palazzolo I, Krainc D, Hyman BT, Berezovska O.

Neurobiol Dis. 2013 Feb;50:127-34. doi: 10.1016/j.nbd.2012.10.002. Epub 2012 Oct 12.

18.

Distinct dendritic spine and nuclear phases of calcineurin activation after exposure to amyloid-β revealed by a novel fluorescence resonance energy transfer assay.

Wu HY, Hudry E, Hashimoto T, Uemura K, Fan ZY, Berezovska O, Grosskreutz CL, Bacskai BJ, Hyman BT.

J Neurosci. 2012 Apr 11;32(15):5298-309. doi: 10.1523/JNEUROSCI.0227-12.2012.

19.

Modification of γ-secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer's disease.

Guix FX, Wahle T, Vennekens K, Snellinx A, Chávez-Gutiérrez L, Ill-Raga G, Ramos-Fernandez E, Guardia-Laguarta C, Lleó A, Arimon M, Berezovska O, Muñoz FJ, Dotti CG, De Strooper B.

EMBO Mol Med. 2012 Jul;4(7):660-73. doi: 10.1002/emmm.201200243. Epub 2012 May 2.

20.

Phenylpiperidine-type γ-secretase modulators target the transmembrane domain 1 of presenilin 1.

Ohki Y, Higo T, Uemura K, Shimada N, Osawa S, Berezovska O, Yokoshima S, Fukuyama T, Tomita T, Iwatsubo T.

EMBO J. 2011 Oct 14;30(23):4815-24. doi: 10.1038/emboj.2011.372.

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