Abstract
In familial PD, a mutation of the alpha-synuclein gene has been identified. Alpha-synuclein also was revealed in Lewy bodies in idiopathic PD. Lewy bodies in neurodegeneration with brain iron accumulation type 1 (NBIA 1; Hallervorden-Spatz syndrome) were found to show immunostaining for alpha-synuclein/precursor of non-A beta component of Alzheimer's disease amyloid, indicating that alpha-synuclein is commonly associated with the formation of Lewy bodies in other sporadic and familial neurodegenerative diseases apart from PD.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Female
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Humans
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Immunohistochemistry
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Iron / metabolism*
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Lewy Bodies / metabolism
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Lewy Bodies / pathology*
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Male
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Nerve Tissue Proteins / metabolism*
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Neurodegenerative Diseases / metabolism
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Neurodegenerative Diseases / pathology*
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Pantothenate Kinase-Associated Neurodegeneration / metabolism
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Pantothenate Kinase-Associated Neurodegeneration / pathology*
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Parkinson Disease / metabolism
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Synucleins
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Ubiquitins / metabolism
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alpha-Synuclein
Substances
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Nerve Tissue Proteins
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SNCA protein, human
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Synucleins
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Ubiquitins
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alpha-Synuclein
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Iron