[Cytokine-producing activity of peripheral mononuclear leukocytes in patients with pulmonary tuberculosis before and during chemotherapy]

V V Novitskiĭ; V A Sinitsyna; O V Voronkova; A K Strelis; O I Urazova; O V Filiniuk; N A Zemlianaia; T A Luk'ianova; I E Esimova

[Cytokine-producing activity of peripheral mononuclear leukocytes in patients with pulmonary tuberculosis before and during chemotherapy]

Probl Tuberk Bolezn Legk. 2005:(6):39-42.

[Article in Russian]

Authors

V V Novitskiĭ, V A Sinitsyna, O V Voronkova, A K Strelis, O I Urazova, O V Filiniuk, N A Zemlianaia, T A Luk'ianova, I E Esimova

PMID: 16078721

Abstract

The paper presents the results of a study of spontaneous and stimulated production of TNF-alpha, INF-gamma, INF-alpha, IL-2 by peripheral mononuclear leukocytes in patients with disseminated destructive drug-resistant pulmonary tuberculosis. It also shows marked changes in the levels the studied cytokines in relation to the type of a stimulant (lipopolysaccharide, phytohemagglutinin, tuberculin) and during antituberculous chemotherapy.

Publication types

English Abstract

MeSH terms

Adult
Antitubercular Agents / pharmacology*
Antitubercular Agents / therapeutic use*
Cytokines / drug effects*
Cytokines / metabolism*
Female
Humans
Leukocytes, Mononuclear / drug effects*
Leukocytes, Mononuclear / metabolism*
Male
Middle Aged
Time Factors
Tuberculosis, Pulmonary* / drug therapy
Tuberculosis, Pulmonary* / metabolism
Tuberculosis, Pulmonary* / physiopathology

Substances

Antitubercular Agents
Cytokines