Abstract
The paper presents the results of a study of spontaneous and stimulated production of TNF-alpha, INF-gamma, INF-alpha, IL-2 by peripheral mononuclear leukocytes in patients with disseminated destructive drug-resistant pulmonary tuberculosis. It also shows marked changes in the levels the studied cytokines in relation to the type of a stimulant (lipopolysaccharide, phytohemagglutinin, tuberculin) and during antituberculous chemotherapy.
MeSH terms
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Adult
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Antitubercular Agents / pharmacology*
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Antitubercular Agents / therapeutic use*
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Cytokines / drug effects*
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Cytokines / metabolism*
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Female
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Humans
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Leukocytes, Mononuclear / drug effects*
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Leukocytes, Mononuclear / metabolism*
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Male
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Middle Aged
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Time Factors
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Tuberculosis, Pulmonary* / drug therapy
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Tuberculosis, Pulmonary* / metabolism
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Tuberculosis, Pulmonary* / physiopathology
Substances
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Antitubercular Agents
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Cytokines