Sirolimus lowers myeloperoxidase and p-ANCA titers in a pediatric patient before kidney transplantation

Am J Kidney Dis. 2002 Aug;40(2):407-10. doi: 10.1053/ajkd.2002.34544.

Abstract

We report the case of a child with microscopic polyangiitis (myeloperoxidase-antineutrophil cytoplasmic antibody [p-ANCA]-positive vasculitis) whose disease progressed to end-stage renal failure, in whom sirolimus contributed to normalization of myeloperoxidase and ANCA titers. The disease course, various therapies, and outcome are discussed, as is the rationale for using sirolimus.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Antibodies, Antineutrophil Cytoplasmic / biosynthesis*
  • Female
  • Humans
  • Immunosuppressive Agents / pharmacology
  • Immunosuppressive Agents / therapeutic use*
  • Kidney Failure, Chronic / blood
  • Kidney Failure, Chronic / etiology
  • Kidney Failure, Chronic / therapy
  • Kidney Transplantation* / methods
  • Peroxidase / antagonists & inhibitors
  • Peroxidase / blood
  • Peroxidase / immunology*
  • Sirolimus / pharmacology
  • Sirolimus / therapeutic use*
  • Transplantation Conditioning / methods*
  • Vasculitis / complications

Substances

  • Antibodies, Antineutrophil Cytoplasmic
  • Immunosuppressive Agents
  • Peroxidase
  • Sirolimus