Abstract
A girl with autosomal dominant hypophosphatemic rickets, presented with clinical, radiological and laboratory signs of rickets at the age of 11 months. She showed a good response to the treatment with low doses of oral phosphate and calcitriol. Surprisingly, she lost her renal phosphate wasting at the age of 8 years, indicating that the disturbed phosphate metabolism can be compensated by hormonal or other factors.
Copyright 2002 S. Karger AG, Basel
MeSH terms
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Administration, Oral
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Aging / metabolism
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Calcitriol / administration & dosage
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Calcitriol / therapeutic use
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Calcium Channel Agonists / administration & dosage
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Calcium Channel Agonists / therapeutic use
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Child
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Female
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Fibroblast Growth Factor-23
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Fibroblast Growth Factors / genetics*
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Genes, Dominant*
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Humans
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Hypophosphatemia, Familial / drug therapy
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Hypophosphatemia, Familial / genetics*
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Kidney / metabolism*
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Mutation*
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Pedigree
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Phosphates / administration & dosage
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Phosphates / metabolism*
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Phosphates / therapeutic use
Substances
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Calcium Channel Agonists
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FGF23 protein, human
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Phosphates
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Fibroblast Growth Factors
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Fibroblast Growth Factor-23
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Calcitriol