[An elderly patient with myelodysplastic syndrome successfully treated with combination of granulocyte-colony stimulating factor and continuous-drip infusion of low-dose cytarabine and etoposide]

Rinsho Ketsueki. 2000 Mar;41(3):218-21.
[Article in Japanese]

Abstract

A 73-year-old man was given a diagnosis of myelodysplastic syndrome in October 1997. He was treated with red blood cell transfusion and granulocyte-colony stimulating factor (G-CSF). In February 1998, he was admitted due to progression of pancytopenia. Bone marrow aspiration revealed refractory anemia with excess of blasts in transformation. The patient was treated with continuous-drip infusion of low-dose cytarabine and etoposide with G-CSF (AVG therapy). Complete remission (CR) was obtained after 2 courses of AVG therapy. Non-hematologic adverse effects were mild enough to be tolerated. CR has been maintained for 16 months with 1 course of consolidation therapy and 3 courses of intensification therapy using the AVG regimen.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Aged
  • Antineoplastic Combined Chemotherapy Protocols / administration & dosage*
  • Cytarabine / administration & dosage*
  • Etoposide / administration & dosage*
  • Granulocyte Colony-Stimulating Factor / administration & dosage*
  • Humans
  • Infusions, Intravenous
  • Male
  • Myelodysplastic Syndromes / drug therapy*

Substances

  • Cytarabine
  • Granulocyte Colony-Stimulating Factor
  • Etoposide