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Strategy for early identification of prediabetes in lean populations: New insight from a prospective Chinese twin cohort of children and young adults.

Wang G, Radovick S, Xu X, Xing H, Tang G, Bartell TR, Wang B, Wang X.

Diabetes Res Clin Pract. 2018 Oct 9;146:101-110. doi: 10.1016/j.diabres.2018.10.003. [Epub ahead of print]


KISS1/KISS1R in Cancer: Friend or Foe?

Guzman S, Brackstone M, Radovick S, Babwah AV, Bhattacharya MM.

Front Endocrinol (Lausanne). 2018 Aug 3;9:437. doi: 10.3389/fendo.2018.00437. eCollection 2018. Review.


Impairments in the Reproductive Axis of Female Mice Lacking Estrogen Receptor β in GnRH Neurons.

Novaira HJ, Negron AL, Graceli JB, Capellino S, Schoeffield A, Hoffman GE, Levine JE, Wolfe A, Wondisford FE, Radovick S.

Am J Physiol Endocrinol Metab. 2018 Jul 24. doi: 10.1152/ajpendo.00173.2018. [Epub ahead of print]


Early Life Weight Gain and Development of Childhood Asthma in a Prospective Birth Cohort.

Tsai HJ, Wang G, Hong X, Yao TC, Ji Y, Radovick S, Ji H, Cheng TL, Wang X.

Ann Am Thorac Soc. 2018 Oct;15(10):1197-1204. doi: 10.1513/AnnalsATS.201712-921OC.


The 3rd World Conference on Kisspeptin, "Kisspeptin 2017: Brain and Beyond":Unresolved questions, challenges and future directions for the field.

Lehman MN, Coolen LM, Steiner RA, Neal-Perry G, Wang L, Moenter SM, Moore AM, Goodman RL, Hwa-Yeo S, Padilla SL, Kauffman AS, Garcia J, Kelly MJ, Clarkson J, Radovick S, Babwah AV, Leon S, Tena-Sempere M, Comninos A, Seminara S, Dhillo WS, Levine J, Terasawa E, Negron A, Herbison AE.

J Neuroendocrinol. 2018 Apr 14:e12600. doi: 10.1111/jne.12600. [Epub ahead of print] Review.


Growth Hormone Research Society perspective on biomarkers of GH action in children and adults.

Johannsson G, Bidlingmaier M, Biller BMK, Boguszewski M, Casanueva FF, Chanson P, Clayton PE, Choong CS, Clemmons D, Dattani M, Frystyk J, Ho K, Hoffman AR, Horikawa R, Juul A, Kopchick JJ, Luo X, Neggers S, Netchine I, Olsson DS, Radovick S, Rosenfeld R, Ross RJ, Schilbach K, Solberg P, Strasburger C, Trainer P, Yuen KCJ, Wickstrom K, Jorgensen JOL; Growth Hormone Research Society.

Endocr Connect. 2018 Mar;7(3):R126-R134. doi: 10.1530/EC-18-0047. Epub 2018 Feb 26. Review.


Pituitary Hypoplasia.

Gangat M, Radovick S.

Endocrinol Metab Clin North Am. 2017 Jun;46(2):247-257. doi: 10.1016/j.ecl.2017.01.003. Epub 2017 Feb 22. Review.


Weight Gain in Infancy and Overweight or Obesity in Childhood across the Gestational Spectrum: a Prospective Birth Cohort Study.

Wang G, Johnson S, Gong Y, Polk S, Divall S, Radovick S, Moon M, Paige D, Hong X, Caruso D, Chen Z, Mallow E, Walker SO, Mao G, Pearson C, Wang MC, Zuckerman B, Cheng TL, Wang X.

Sci Rep. 2016 Jul 15;6:29867. doi: 10.1038/srep29867.


Activation of the cAMP-PKA pathway Antagonizes Metformin Suppression of Hepatic Glucose Production.

He L, Chang E, Peng J, An H, McMillin SM, Radovick S, Stratakis CA, Wondisford FE.

J Biol Chem. 2016 May 13;291(20):10562-70. doi: 10.1074/jbc.M116.719666. Epub 2016 Mar 21.


Altered somatotroph feedback regulation improves metabolic efficiency and limits adipose deposition in male mice.

Romero CJ, Wolfe A, Law YY, Costelloe CZ, Miller R, Wondisford F, Radovick S.

Metabolism. 2016 Apr;65(4):557-68. doi: 10.1016/j.metabol.2015.11.009. Epub 2015 Dec 8.


Estradiol Restrains Prepubertal Gonadotropin Secretion in Female Mice via Activation of ERα in Kisspeptin Neurons.

Dubois SL, Wolfe A, Radovick S, Boehm U, Levine JE.

Endocrinology. 2016 Apr;157(4):1546-54. doi: 10.1210/en.2015-1923. Epub 2016 Jan 29.


Insulin receptor signaling in the GnRH neuron plays a role in the abnormal GnRH pulsatility of obese female mice.

DiVall SA, Herrera D, Sklar B, Wu S, Wondisford F, Radovick S, Wolfe A.

PLoS One. 2015 Mar 17;10(3):e0119995. doi: 10.1371/journal.pone.0119995. eCollection 2015.


Developmental and endocrine regulation of kisspeptin expression in mouse Leydig cells.

Salehi S, Adeshina I, Chen H, Zirkin BR, Hussain MA, Wondisford F, Wolfe A, Radovick S.

Endocrinology. 2015 Apr;156(4):1514-22. doi: 10.1210/en.2014-1606. Epub 2015 Jan 30.


Positive, but not negative feedback actions of estradiol in adult female mice require estrogen receptor α in kisspeptin neurons.

Dubois SL, Acosta-Martínez M, DeJoseph MR, Wolfe A, Radovick S, Boehm U, Urban JH, Levine JE.

Endocrinology. 2015 Mar;156(3):1111-20. doi: 10.1210/en.2014-1851. Epub 2014 Dec 29.


Metformin activates AMP-activated protein kinase by promoting formation of the αβγ heterotrimeric complex.

Meng S, Cao J, He Q, Xiong L, Chang E, Radovick S, Wondisford FE, He L.

J Biol Chem. 2015 Feb 6;290(6):3793-802. doi: 10.1074/jbc.M114.604421. Epub 2014 Dec 23.


Low concentrations of metformin suppress glucose production in hepatocytes through AMP-activated protein kinase (AMPK).

Cao J, Meng S, Chang E, Beckwith-Fickas K, Xiong L, Cole RN, Radovick S, Wondisford FE, He L.

J Biol Chem. 2014 Jul 25;289(30):20435-46.


Glucagon regulates hepatic kisspeptin to impair insulin secretion.

Song WJ, Mondal P, Wolfe A, Alonso LC, Stamateris R, Ong BW, Lim OC, Yang KS, Radovick S, Novaira HJ, Farber EA, Farber CR, Turner SD, Hussain MA.

Cell Metab. 2014 Apr 1;19(4):667-81. doi: 10.1016/j.cmet.2014.03.005.


Potential biomarker of metformin action.

He L, Meng S, Germain-Lee EL, Radovick S, Wondisford FE.

J Endocrinol. 2014 Jun;221(3):363-9. doi: 10.1530/JOE-14-0084. Epub 2014 Mar 17.


Preterm birth and random plasma insulin levels at birth and in early childhood.

Wang G, Divall S, Radovick S, Paige D, Ning Y, Chen Z, Ji Y, Hong X, Walker SO, Caruso D, Pearson C, Wang MC, Zuckerman B, Cheng TL, Wang X.

JAMA. 2014 Feb 12;311(6):587-96. doi: 10.1001/jama.2014.1.


Disrupted kisspeptin signaling in GnRH neurons leads to hypogonadotrophic hypogonadism.

Novaira HJ, Sonko ML, Hoffman G, Koo Y, Ko C, Wolfe A, Radovick S.

Mol Endocrinol. 2014 Feb;28(2):225-38. doi: 10.1210/me.2013-1319. Epub 2014 Jan 1.


Obesity-induced infertility and hyperandrogenism are corrected by deletion of the insulin receptor in the ovarian theca cell.

Wu S, Divall S, Nwaopara A, Radovick S, Wondisford F, Ko C, Wolfe A.

Diabetes. 2014 Apr;63(4):1270-82. doi: 10.2337/db13-1514. Epub 2013 Dec 30.


Both estrogen receptor α and β stimulate pituitary GH gene expression.

Avtanski D, Novaira HJ, Wu S, Romero CJ, Kineman R, Luque RM, Wondisford F, Radovick S.

Mol Endocrinol. 2014 Jan;28(1):40-52. doi: 10.1210/me.2013-1245. Epub 2013 Jan 1.


Isolated prolactin deficiency associated with serum autoantibodies against prolactin-secreting cells.

Iwama S, Welt CK, Romero CJ, Radovick S, Caturegli P.

J Clin Endocrinol Metab. 2013 Oct;98(10):3920-5. doi: 10.1210/jc.2013-2411. Epub 2013 Aug 12. Erratum in: J Clin Endocrinol Metab. 2013 Dec;98(12):4992.


Growth Hormone and Treatment Controversy; Long Term Safety of rGH.

Divall SA, Radovick S.

Curr Pediatr Rep. 2013 Jun 1;1(2):128-132.


Activation of basal gluconeogenesis by coactivator p300 maintains hepatic glycogen storage.

He L, Cao J, Meng S, Ma A, Radovick S, Wondisford FE.

Mol Endocrinol. 2013 Aug;27(8):1322-32. doi: 10.1210/me.2012-1413. Epub 2013 Jun 14.


GrowthHormone Research Society workshop summary: consensus guidelines for recombinant human growth hormone therapy in Prader-Willi syndrome.

Deal CL, Tony M, Höybye C, Allen DB, Tauber M, Christiansen JS; 2011 Growth Hormone in Prader-Willi Syndrome Clinical Care Guidelines Workshop Participants.

J Clin Endocrinol Metab. 2013 Jun;98(6):E1072-87. doi: 10.1210/jc.2012-3888. Epub 2013 Mar 29. Review.


Vertical transmission of hypopituitarism: critical importance of appropriate interpretation of thyroid function tests and levothyroxine therapy during pregnancy.

Pine-Twaddell E, Romero CJ, Radovick S.

Thyroid. 2013 Jul;23(7):892-7. doi: 10.1089/thy.2012.0332. Epub 2013 Jun 21.


Genetic mechanisms mediating kisspeptin regulation of GnRH gene expression.

Novaira HJ, Fadoju D, Diaczok D, Radovick S.

J Neurosci. 2012 Nov 28;32(48):17391-400. doi: 10.1523/JNEUROSCI.2438-12.2012.


Insulin-like growth factor 1 mediates negative feedback to somatotroph GH expression via POU1F1/CREB binding protein interactions.

Romero CJ, Pine-Twaddell E, Sima DI, Miller RS, He L, Wondisford F, Radovick S.

Mol Cell Biol. 2012 Nov;32(21):4258-69. doi: 10.1128/MCB.00171-12. Epub 2012 Aug 13.


Transcriptional co-activator p300 maintains basal hepatic gluconeogenesis.

He L, Naik K, Meng S, Cao J, Sidhaye AR, Ma A, Radovick S, Wondisford FE.

J Biol Chem. 2012 Sep 14;287(38):32069-77. doi: 10.1074/jbc.M112.385864. Epub 2012 Jul 19.


A novel OTX2 mutation in a patient with combined pituitary hormone deficiency, pituitary malformation, and an underdeveloped left optic nerve.

Gorbenko Del Blanco D, Romero CJ, Diaczok D, de Graaff LC, Radovick S, Hokken-Koelega AC.

Eur J Endocrinol. 2012 Sep;167(3):441-52. doi: 10.1530/EJE-12-0333. Epub 2012 Jun 19.


Estrogenic regulation of the GnRH neuron.

Radovick S, Levine JE, Wolfe A.

Front Endocrinol (Lausanne). 2012 Apr 9;3:52. doi: 10.3389/fendo.2012.00052. eCollection 2012.


CREB binding protein (CBP) activation is required for luteinizing hormone beta expression and normal fertility in mice.

Miller RS, Wolfe A, He L, Radovick S, Wondisford FE.

Mol Cell Biol. 2012 Jul;32(13):2349-58. doi: 10.1128/MCB.00394-12. Epub 2012 Apr 16.


Genetic overlap in Kallmann syndrome, combined pituitary hormone deficiency, and septo-optic dysplasia.

Raivio T, Avbelj M, McCabe MJ, Romero CJ, Dwyer AA, Tommiska J, Sykiotis GP, Gregory LC, Diaczok D, Tziaferi V, Elting MW, Padidela R, Plummer L, Martin C, Feng B, Zhang C, Zhou QY, Chen H, Mohammadi M, Quinton R, Sidis Y, Radovick S, Dattani MT, Pitteloud N.

J Clin Endocrinol Metab. 2012 Apr;97(4):E694-9. doi: 10.1210/jc.2011-2938. Epub 2012 Feb 8.


Long-term surveillance of growth hormone therapy.

Rosenfeld RG, Cohen P, Robison LL, Bercu BB, Clayton P, Hoffman AR, Radovick S, Saenger P, Savage MO, Wit JM.

J Clin Endocrinol Metab. 2012 Jan;97(1):68-72. doi: 10.1210/jc.2011-2294. Epub 2011 Dec 15. Review. No abstract available.


Novel mutations associated with combined pituitary hormone deficiency.

Romero CJ, Pine-Twaddell E, Radovick S.

J Mol Endocrinol. 2011 Jun 9;46(3):R93-R102. doi: 10.1530/JME-10-0133. Print 2011 Jun. Review.


Deletion of Otx2 in GnRH neurons results in a mouse model of hypogonadotropic hypogonadism.

Diaczok D, DiVall S, Matsuo I, Wondisford FE, Wolfe AM, Radovick S.

Mol Endocrinol. 2011 May;25(5):833-46. doi: 10.1210/me.2010-0271. Epub 2011 Mar 24.


The gonadotropin-releasing hormone cell-specific element is required for normal puberty and estrous cyclicity.

Novaira HJ, Yates M, Diaczok D, Kim H, Wolfe A, Radovick S.

J Neurosci. 2011 Mar 2;31(9):3336-43. doi: 10.1523/JNEUROSCI.5419-10.2011.


Timing and completion of puberty in female mice depend on estrogen receptor alpha-signaling in kisspeptin neurons.

Mayer C, Acosta-Martinez M, Dubois SL, Wolfe A, Radovick S, Boehm U, Levine JE.

Proc Natl Acad Sci U S A. 2010 Dec 28;107(52):22693-8. doi: 10.1073/pnas.1012406108. Epub 2010 Dec 13.


Rescue of obesity-induced infertility in female mice due to a pituitary-specific knockout of the insulin receptor.

Brothers KJ, Wu S, DiVall SA, Messmer MR, Kahn CR, Miller RS, Radovick S, Wondisford FE, Wolfe A.

Cell Metab. 2010 Sep 8;12(3):295-305. doi: 10.1016/j.cmet.2010.06.010.


Divergent roles of growth factors in the GnRH regulation of puberty in mice.

Divall SA, Williams TR, Carver SE, Koch L, Brüning JC, Kahn CR, Wondisford F, Radovick S, Wolfe A.

J Clin Invest. 2010 Aug;120(8):2900-9. doi: 10.1172/JCI41069. Epub 2010 Jul 12.


Targeted deletion of somatotroph insulin-like growth factor-I signaling in a cell-specific knockout mouse model.

Romero CJ, Ng Y, Luque RM, Kineman RD, Koch L, Bruning JC, Radovick S.

Mol Endocrinol. 2010 May;24(5):1077-89. doi: 10.1210/me.2009-0393. Epub 2010 Mar 8.


The molecular basis of hypopituitarism.

Romero CJ, Nesi-França S, Radovick S.

Trends Endocrinol Metab. 2009 Dec;20(10):506-16. doi: 10.1016/j.tem.2009.06.005. Epub 2009 Oct 23. Review.


Kisspeptin increases GnRH mRNA expression and secretion in GnRH secreting neuronal cell lines.

Novaira HJ, Ng Y, Wolfe A, Radovick S.

Mol Cell Endocrinol. 2009 Nov 13;311(1-2):126-34. doi: 10.1016/j.mce.2009.06.011. Epub 2009 Jul 1.


Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein.

He L, Sabet A, Djedjos S, Miller R, Sun X, Hussain MA, Radovick S, Wondisford FE.

Cell. 2009 May 15;137(4):635-46. doi: 10.1016/j.cell.2009.03.016.


Impaired estrogen feedback and infertility in female mice with pituitary-specific deletion of estrogen receptor alpha (ESR1).

Singh SP, Wolfe A, Ng Y, DiVall SA, Buggs C, Levine JE, Wondisford FE, Radovick S.

Biol Reprod. 2009 Sep;81(3):488-96. doi: 10.1095/biolreprod.108.075259. Epub 2009 May 13.


Estrogen regulation of gene expression in GnRH neurons.

Ng Y, Wolfe A, Novaira HJ, Radovick S.

Mol Cell Endocrinol. 2009 May 6;303(1-2):25-33. doi: 10.1016/j.mce.2009.01.016. Epub 2009 Feb 2.


Endocrinology of female puberty.

DiVall SA, Radovick S.

Curr Opin Endocrinol Diabetes Obes. 2009 Feb;16(1):1-4. Review.


Generation and characterization of a complete null estrogen receptor alpha mouse using Cre/LoxP technology.

Chen M, Wolfe A, Wang X, Chang C, Yeh S, Radovick S.

Mol Cell Biochem. 2009 Jan;321(1-2):145-53. doi: 10.1007/s11010-008-9928-9. Epub 2008 Oct 25.


Consensus statement on the diagnosis and treatment of children with idiopathic short stature: a summary of the Growth Hormone Research Society, the Lawson Wilkins Pediatric Endocrine Society, and the European Society for Paediatric Endocrinology Workshop.

Cohen P, Rogol AD, Deal CL, Saenger P, Reiter EO, Ross JL, Chernausek SD, Savage MO, Wit JM; 2007 ISS Consensus Workshop participants.

J Clin Endocrinol Metab. 2008 Nov;93(11):4210-7. doi: 10.1210/jc.2008-0509. Epub 2008 Sep 9.


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