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Development and validation of prediction scores for nosocomial infections, reoperations, and adverse events in the daily clinical setting of neurosurgical patients with cerebral and spinal tumors.

Lohmann S, Brix T, Varghese J, Warneke N, Schwake M, Suero Molina E, Holling M, Stummer W, Schipmann S.

J Neurosurg. 2020 Mar 20:1-11. doi: 10.3171/2020.1.JNS193186. [Epub ahead of print]


Diagnostic accuracy of different clinical screening criteria for blunt cerebrovascular injuries compared to liberal state of the art computed tomography angiography in major trauma.

Müther M, Sporns PB, Hanning U, Düsing H, Hartensuer R, Raschke M, Schwake M, Stummer W, Glasgow S.

J Trauma Acute Care Surg. 2020 Mar 18. doi: 10.1097/TA.0000000000002682. [Epub ahead of print]


LRRK2 kinase activity regulates lysosomal glucocerebrosidase in neurons derived from Parkinson's disease patients.

Ysselstein D, Nguyen M, Young TJ, Severino A, Schwake M, Merchant K, Krainc D.

Nat Commun. 2019 Dec 5;10(1):5570. doi: 10.1038/s41467-019-13413-w.


Markers for Identifying and Targeting Glioblastoma Cells during Surgery.

Schipmann S, Schwake M, Suero Molina E, Stummer W.

J Neurol Surg A Cent Eur Neurosurg. 2019 Nov;80(6):475-487. doi: 10.1055/s-0039-1692976. Epub 2019 Aug 29. Review.


Spectroscopic measurement of 5-ALA-induced intracellular protoporphyrin IX in pediatric brain tumors.

Schwake M, Kaneko S, Suero Molina E, Müther M, Schipmann S, Köchling M, Brentrup A, Stummer W.

Acta Neurochir (Wien). 2019 Oct;161(10):2099-2105. doi: 10.1007/s00701-019-04039-4. Epub 2019 Aug 21.


Lysosomal integral membrane protein-2 (LIMP-2/SCARB2) is involved in lysosomal cholesterol export.

Heybrock S, Kanerva K, Meng Y, Ing C, Liang A, Xiong ZJ, Weng X, Ah Kim Y, Collins R, Trimble W, Pomès R, Privé GG, Annaert W, Schwake M, Heeren J, Lüllmann-Rauch R, Grinstein S, Ikonen E, Saftig P, Neculai D.

Nat Commun. 2019 Aug 6;10(1):3521. doi: 10.1038/s41467-019-11425-0.


Dual labeling with 5-aminolevulinic acid and fluorescein in high-grade glioma surgery with a prototype filter system built into a neurosurgical microscope: technical note.

Suero Molina E, Ewelt C, Warneke N, Schwake M, Müther M, Schipmann S, Stummer W.

J Neurosurg. 2019 Apr 26:1-7. doi: 10.3171/2018.12.JNS182422. [Epub ahead of print]


Establishing risk-adjusted quality indicators in surgery using administrative data-an example from neurosurgery.

Schipmann S, Varghese J, Brix T, Schwake M, Keurhorst D, Lohmann S, Suero Molina E, Mauer UM, Dugas M, Warneke N, Stummer W.

Acta Neurochir (Wien). 2019 Jun;161(6):1057-1065. doi: 10.1007/s00701-018-03792-2. Epub 2019 Apr 26.


5-ALA fluorescence-guided surgery in pediatric brain tumors-a systematic review.

Schwake M, Schipmann S, Müther M, Köchling M, Brentrup A, Stummer W.

Acta Neurochir (Wien). 2019 Jun;161(6):1099-1108. doi: 10.1007/s00701-019-03898-1. Epub 2019 Apr 13. Review.


Adverse events in brain tumor surgery: incidence, type, and impact on current quality metrics.

Schipmann S, Brix T, Varghese J, Warneke N, Schwake M, Brokinkel B, Ewelt C, Dugas M, Stummer W.

Acta Neurochir (Wien). 2019 Feb;161(2):287-306. doi: 10.1007/s00701-018-03790-4. Epub 2019 Jan 11.


Second-look strokectomy of cerebral infarction areas in patients with severe herniation.

Schwake M, Schipmann S, Müther M, Stögbauer L, Hanning U, Sporns PB, Ewelt C, Dziewas R, Minnerup J, Holling M, Stummer W.

J Neurosurg. 2019 Jan 4;132(1):1-9. doi: 10.3171/2018.8.JNS18692.


Triage of 5 Noncontrast Computed Tomography Markers and Spot Sign for Outcome Prediction After Intracerebral Hemorrhage.

Sporns PB, Kemmling A, Schwake M, Minnerup J, Nawabi J, Broocks G, Wildgruber M, Fiehler J, Heindel W, Hanning U.

Stroke. 2018 Oct;49(10):2317-2322. doi: 10.1161/STROKEAHA.118.021625.


Doxorubicin induces caspase-mediated proteolysis of KV7.1.

Strigli A, Raab C, Hessler S, Huth T, Schuldt AJT, Alzheimer C, Friedrich T, Burridge PW, Luedde M, Schwake M.

Commun Biol. 2018 Sep 28;1:155. doi: 10.1038/s42003-018-0162-z. eCollection 2018.


Spinal meningiomas - Risks and potential of an increasing age at the time of surgery.

Schwake M, Adeli A, Sporns P, Ewelt C, Schmitz T, Sicking J, Hess K, Cäcilia Spille D, Paulus W, Stummer W, Brokinkel B.

J Clin Neurosci. 2018 Nov;57:86-92. doi: 10.1016/j.jocn.2018.08.030. Epub 2018 Aug 23.


Is the Simpson Grading System Applicable to Estimate the Risk of Tumor Progression After Microsurgery for Recurrent Intracranial Meningioma?

Schipmann S, Schwake M, Sporns PB, Voß KM, Sicking J, Spille DC, Hess K, Paulus W, Stummer W, Brokinkel B.

World Neurosurg. 2018 Nov;119:e589-e597. doi: 10.1016/j.wneu.2018.07.215. Epub 2018 Aug 4.


β-Glucocerebrosidase Modulators Promote Dimerization of β-Glucocerebrosidase and Reveal an Allosteric Binding Site.

Zheng J, Chen L, Skinner OS, Ysselstein D, Remis J, Lansbury P, Skerlj R, Mrosek M, Heunisch U, Krapp S, Charrow J, Schwake M, Kelleher NL, Silverman RB, Krainc D.

J Am Chem Soc. 2018 May 9;140(18):5914-5924. doi: 10.1021/jacs.7b13003. Epub 2018 Apr 30.


In-Vitro Use of 5-ALA for Photodynamic Therapy in Pediatric Brain Tumors.

Schwake M, Nemes A, Dondrop J, Schroeteler J, Schipmann S, Senner V, Stummer W, Ewelt C.

Neurosurgery. 2018 Dec 1;83(6):1328-1337. doi: 10.1093/neuros/nyy054.


Lysosomal integral membrane protein-2 as a phospholipid receptor revealed by biophysical and cellular studies.

Conrad KS, Cheng TW, Ysselstein D, Heybrock S, Hoth LR, Chrunyk BA, Am Ende CW, Krainc D, Schwake M, Saftig P, Liu S, Qiu X, Ehlers MD.

Nat Commun. 2017 Dec 4;8(1):1908. doi: 10.1038/s41467-017-02044-8.


Mutations in the X-linked ATP6AP2 cause a glycosylation disorder with autophagic defects.

Rujano MA, Cannata Serio M, Panasyuk G, Péanne R, Reunert J, Rymen D, Hauser V, Park JH, Freisinger P, Souche E, Guida MC, Maier EM, Wada Y, Jäger S, Krogan NJ, Kretz O, Nobre S, Garcia P, Quelhas D, Bird TD, Raskind WH, Schwake M, Duvet S, Foulquier F, Matthijs G, Marquardt T, Simons M.

J Exp Med. 2017 Dec 4;214(12):3707-3729. doi: 10.1084/jem.20170453. Epub 2017 Nov 10.


Comparison of Spot Sign, Blend Sign and Black Hole Sign for Outcome Prediction in Patients with Intracerebral Hemorrhage.

Sporns PB, Schwake M, Kemmling A, Minnerup J, Schwindt W, Niederstadt T, Schmidt R, Hanning U.

J Stroke. 2017 Sep;19(3):333-339. doi: 10.5853/jos.2016.02061. Epub 2017 Sep 29.


Progranulin-mediated deficiency of cathepsin D results in FTD and NCL-like phenotypes in neurons derived from FTD patients.

Valdez C, Wong YC, Schwake M, Bu G, Wszolek ZK, Krainc D.

Hum Mol Genet. 2017 Dec 15;26(24):4861-4872. doi: 10.1093/hmg/ddx364.


Functional assays for the assessment of the pathogenicity of variants of GOSR2, an ER-to-Golgi SNARE involved in progressive myoclonus epilepsies.

Völker JM, Dergai M, Abriata LA, Mingard Y, Ysselstein D, Krainc D, Dal Peraro M, Fischer von Mollard G, Fasshauer D, Koliwer J, Schwake M.

Dis Model Mech. 2017 Dec 19;10(12):1391-1398. doi: 10.1242/dmm.029132.


Regression of Pineal Lesions: Spontaneous or Iatrogenic? A Case Report and Systematic Literature Review.

Schipmann S, Keurhorst D, Köchling M, Schwake M, Heß K, Sundermann B, Stummer W, Brentrup A.

World Neurosurg. 2017 Dec;108:939-947.e1. doi: 10.1016/j.wneu.2017.08.106. Epub 2017 Aug 24. Review.


Quality Indicators in Cranial Neurosurgery: Which Are Presently Substantiated? A Systematic Review.

Schipmann S, Schwake M, Suero Molina E, Roeder N, Steudel WI, Warneke N, Stummer W.

World Neurosurg. 2017 Aug;104:104-112. doi: 10.1016/j.wneu.2017.03.111. Epub 2017 Apr 30. Review.


Computed Tomographic Blend Sign Is Associated With Computed Tomographic Angiography Spot Sign and Predicts Secondary Neurological Deterioration After Intracerebral Hemorrhage.

Sporns PB, Schwake M, Schmidt R, Kemmling A, Minnerup J, Schwindt W, Cnyrim C, Zoubi T, Heindel W, Niederstadt T, Hanning U.

Stroke. 2017 Jan;48(1):131-135. doi: 10.1161/STROKEAHA.116.014068. Epub 2016 Nov 22.


Design and Synthesis of Potent Quinazolines as Selective β-Glucocerebrosidase Modulators.

Zheng J, Chen L, Schwake M, Silverman RB, Krainc D.

J Med Chem. 2016 Sep 22;59(18):8508-20. doi: 10.1021/acs.jmedchem.6b00930. Epub 2016 Sep 6.


SCARB2/LIMP2 deficiency in action myoclonus-renal failure syndrome.

Dibbens L, Schwake M, Saftig P, Rubboli G.

Epileptic Disord. 2016 Sep 1;18(S2):63-72. Review.


Characterization of the complex formed by β-glucocerebrosidase and the lysosomal integral membrane protein type-2.

Zunke F, Andresen L, Wesseler S, Groth J, Arnold P, Rothaug M, Mazzulli JR, Krainc D, Blanz J, Saftig P, Schwake M.

Proc Natl Acad Sci U S A. 2016 Apr 5;113(14):3791-6. doi: 10.1073/pnas.1514005113. Epub 2016 Mar 21.


Impaired Lysosomal Integral Membrane Protein 2-dependent Peroxiredoxin 6 Delivery to Lamellar Bodies Accounts for Altered Alveolar Phospholipid Content in Adaptor Protein-3-deficient pearl Mice.

Kook S, Wang P, Young LR, Schwake M, Saftig P, Weng X, Meng Y, Neculai D, Marks MS, Gonzales L, Beers MF, Guttentag S.

J Biol Chem. 2016 Apr 15;291(16):8414-27. doi: 10.1074/jbc.M116.720201. Epub 2016 Feb 23.


Intraoperative myelography of traumatic spine injury in patients with ankylosing spondylitis. Technical note.

Schwake M, Zoubi T, Schipmann S, Stummer W, Ewelt C.

Acta Neurochir (Wien). 2016 Apr;158(4):745-748. doi: 10.1007/s00701-016-2745-0. Epub 2016 Feb 22.


BACE1 modulates gating of KCNQ1 (Kv7.1) and cardiac delayed rectifier KCNQ1/KCNE1 (IKs).

Agsten M, Hessler S, Lehnert S, Volk T, Rittger A, Hartmann S, Raab C, Kim DY, Groemer TW, Schwake M, Alzheimer C, Huth T.

J Mol Cell Cardiol. 2015 Dec;89(Pt B):335-48. doi: 10.1016/j.yjmcc.2015.10.006. Epub 2015 Oct 8.


Mannose 6-phosphate-independent Lysosomal Sorting of LIMP-2.

Blanz J, Zunke F, Markmann S, Damme M, Braulke T, Saftig P, Schwake M.

Traffic. 2015 Oct;16(10):1127-36. doi: 10.1111/tra.12313. Epub 2015 Sep 1.


Vacuolar ATPase in phagosome-lysosome fusion.

Kissing S, Hermsen C, Repnik U, Nesset CK, von Bargen K, Griffiths G, Ichihara A, Lee BS, Schwake M, De Brabander J, Haas A, Saftig P.

J Biol Chem. 2015 May 29;290(22):14166-80. doi: 10.1074/jbc.M114.628891. Epub 2015 Apr 22.


Simultaneous fluorescein sodium and 5-ALA in fluorescence-guided glioma surgery.

Schwake M, Stummer W, Suero Molina EJ, Wölfer J.

Acta Neurochir (Wien). 2015 May;157(5):877-9. doi: 10.1007/s00701-015-2401-0. Epub 2015 Mar 28. No abstract available.


β-Secretase BACE1 regulates hippocampal and reconstituted M-currents in a β-subunit-like fashion.

Hessler S, Zheng F, Hartmann S, Rittger A, Lehnert S, Völkel M, Nissen M, Edelmann E, Saftig P, Schwake M, Huth T, Alzheimer C.

J Neurosci. 2015 Feb 25;35(8):3298-311. doi: 10.1523/JNEUROSCI.3127-14.2015.


Lysosomal integral membrane protein type-2 (LIMP-2/SCARB2) is a substrate of cathepsin-F, a cysteine protease mutated in type-B-Kufs-disease.

Peters J, Rittger A, Weisner R, Knabbe J, Zunke F, Rothaug M, Damme M, Berkovic SF, Blanz J, Saftig P, Schwake M.

Biochem Biophys Res Commun. 2015 Feb 13;457(3):334-40. doi: 10.1016/j.bbrc.2014.12.111. Epub 2015 Jan 7.


LIMP-2 expression is critical for β-glucocerebrosidase activity and α-synuclein clearance.

Rothaug M, Zunke F, Mazzulli JR, Schweizer M, Altmeppen H, Lüllmann-Rauch R, Kallemeijn WW, Gaspar P, Aerts JM, Glatzel M, Saftig P, Krainc D, Schwake M, Blanz J.

Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):15573-8. doi: 10.1073/pnas.1405700111. Epub 2014 Oct 14.


Increased expression of (pro)renin receptor does not cause hypertension or cardiac and renal fibrosis in mice.

Rosendahl A, Niemann G, Lange S, Ahadzadeh E, Krebs C, Contrepas A, van Goor H, Wiech T, Bader M, Schwake M, Peters J, Stahl R, Nguyen G, Wenzel UO.

Lab Invest. 2014 Aug;94(8):863-72. doi: 10.1038/labinvest.2014.83. Epub 2014 Jul 21.


Kinetics of porphyrin fluorescence accumulation in pediatric brain tumor cells incubated in 5-aminolevulinic acid.

Schwake M, Günes D, Köchling M, Brentrup A, Schroeteler J, Hotfilder M, Fruehwald MC, Stummer W, Ewelt C.

Acta Neurochir (Wien). 2014 Jun;156(6):1077-84. doi: 10.1007/s00701-014-2096-7. Epub 2014 Apr 29.


Polo-like kinase 2, a novel ADAM17 signaling component, regulates tumor necrosis factor α ectodomain shedding.

Schwarz J, Schmidt S, Will O, Koudelka T, Köhler K, Boss M, Rabe B, Tholey A, Scheller J, Schmidt-Arras D, Schwake M, Rose-John S, Chalaris A.

J Biol Chem. 2014 Jan 31;289(5):3080-93. doi: 10.1074/jbc.M113.536847. Epub 2013 Dec 13.


GRIN2B mutations in West syndrome and intellectual disability with focal epilepsy.

Lemke JR, Hendrickx R, Geider K, Laube B, Schwake M, Harvey RJ, James VM, Pepler A, Steiner I, Hörtnagel K, Neidhardt J, Ruf S, Wolff M, Bartholdi D, Caraballo R, Platzer K, Suls A, De Jonghe P, Biskup S, Weckhuysen S.

Ann Neurol. 2014 Jan;75(1):147-54. doi: 10.1002/ana.24073. Epub 2014 Jan 2.


Action myoclonus-renal failure syndrome: diagnostic applications of activity-based probes and lipid analysis.

Gaspar P, Kallemeijn WW, Strijland A, Scheij S, Van Eijk M, Aten J, Overkleeft HS, Balreira A, Zunke F, Schwake M, Sá Miranda C, Aerts JM.

J Lipid Res. 2014 Jan;55(1):138-45. doi: 10.1194/jlr.M043802. Epub 2013 Nov 8.


Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36.

Neculai D, Schwake M, Ravichandran M, Zunke F, Collins RF, Peters J, Neculai M, Plumb J, Loppnau P, Pizarro JC, Seitova A, Trimble WS, Saftig P, Grinstein S, Dhe-Paganon S.

Nature. 2013 Dec 5;504(7478):172-6. doi: 10.1038/nature12684. Epub 2013 Oct 27.


Mutations in GRIN2A cause idiopathic focal epilepsy with rolandic spikes.

Lemke JR, Lal D, Reinthaler EM, Steiner I, Nothnagel M, Alber M, Geider K, Laube B, Schwake M, Finsterwalder K, Franke A, Schilhabel M, Jähn JA, Muhle H, Boor R, Van Paesschen W, Caraballo R, Fejerman N, Weckhuysen S, De Jonghe P, Larsen J, Møller RS, Hjalgrim H, Addis L, Tang S, Hughes E, Pal DK, Veri K, Vaher U, Talvik T, Dimova P, Guerrero López R, Serratosa JM, Linnankivi T, Lehesjoki AE, Ruf S, Wolff M, Buerki S, Wohlrab G, Kroell J, Datta AN, Fiedler B, Kurlemann G, Kluger G, Hahn A, Haberlandt DE, Kutzer C, Sperner J, Becker F, Weber YG, Feucht M, Steinböck H, Neophythou B, Ronen GM, Gruber-Sedlmayr U, Geldner J, Harvey RJ, Hoffmann P, Herms S, Altmüller J, Toliat MR, Thiele H, Nürnberg P, Wilhelm C, Stephani U, Helbig I, Lerche H, Zimprich F, Neubauer BA, Biskup S, von Spiczak S.

Nat Genet. 2013 Sep;45(9):1067-72. doi: 10.1038/ng.2728. Epub 2013 Aug 11.


Lysosomal membrane proteins and their central role in physiology.

Schwake M, Schröder B, Saftig P.

Traffic. 2013 Jul;14(7):739-48. doi: 10.1111/tra.12056. Epub 2013 Mar 6. Review.


Cathepsin F mutations cause Type B Kufs disease, an adult-onset neuronal ceroid lipofuscinosis.

Smith KR, Dahl HH, Canafoglia L, Andermann E, Damiano J, Morbin M, Bruni AC, Giaccone G, Cossette P, Saftig P, Grötzinger J, Schwake M, Andermann F, Staropoli JF, Sims KB, Mole SE, Franceschetti S, Alexander NA, Cooper JD, Chapman HA, Carpenter S, Berkovic SF, Bahlo M.

Hum Mol Genet. 2013 Apr 1;22(7):1417-23. doi: 10.1093/hmg/dds558. Epub 2013 Jan 7.


Parallel regulation of renin and lysosomal integral membrane protein 2 in renin-producing cells: further evidence for a lysosomal nature of renin secretory vesicles.

Schmid J, Oelbe M, Saftig P, Schwake M, Schweda F.

Pflugers Arch. 2013 Jun;465(6):895-905. doi: 10.1007/s00424-012-1192-x. Epub 2012 Dec 11.


A critical histidine residue within LIMP-2 mediates pH sensitive binding to its ligand β-glucocerebrosidase.

Zachos C, Blanz J, Saftig P, Schwake M.

Traffic. 2012 Aug;13(8):1113-23. doi: 10.1111/j.1600-0854.2012.01372.x. Epub 2012 May 15.


Tetraspanin15 regulates cellular trafficking and activity of the ectodomain sheddase ADAM10.

Prox J, Willenbrock M, Weber S, Lehmann T, Schmidt-Arras D, Schwanbeck R, Saftig P, Schwake M.

Cell Mol Life Sci. 2012 Sep;69(17):2919-32. doi: 10.1007/s00018-012-0960-2. Epub 2012 Mar 25.


Pharmacological dissection of K(v)7.1 channels in systemic and pulmonary arteries.

Chadha PS, Zunke F, Davis AJ, Jepps TA, Linders JT, Schwake M, Towart R, Greenwood IA.

Br J Pharmacol. 2012 Jun;166(4):1377-87. doi: 10.1111/j.1476-5381.2012.01863.x.

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