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Relative Contributions of Myostatin and the GH/IGF-1 Axis in Body Composition and Muscle Strength.

Lozier NR, Kopchick JJ, de Lacalle S.

Front Physiol. 2018 Nov 1;9:1418. doi: 10.3389/fphys.2018.01418. eCollection 2018.


Growth hormone controls lipolysis by regulation of FSP27 expression.

Sharma R, Luong Q, Sharma VM, Harberson M, Harper B, Colborn A, Berryman DE, Jessen N, Jørgensen JOL, Kopchick JJ, Puri V, Lee KY.

J Endocrinol. 2018 Dec 1;239(3):289-301. doi: 10.1530/JOE-18-0282.


Growth Hormone Discovery and Structure.

Buchman M, Bell S, Kopchick JJ.

Pediatr Endocrinol Rev. 2018 Sep;16(Suppl 1):2-10. doi: 10.17458/per.vol16.2018.bbk.ghdiscoverystructure.


Growth hormone acts along PPARγ-FSP27 axis to stimulate lipolysis in human adipocytes.

Sharma VM, Vestergaard ET, Jessen N, Kolind-Thomsen P, Nellemann B, Nielsen TS, Vendelbo MH, Møller N, Sharma R, Lee KY, Kopchick JJ, Jørgensen JOL, Puri V.

Am J Physiol Endocrinol Metab. 2018 Oct 16. doi: 10.1152/ajpendo.00129.2018. [Epub ahead of print]


Mitochondrial Function Is Compromised in Cortical Bone Osteocytes of Long-Lived Growth Hormone Receptor Null Mice.

Liu Z, Solesio ME, Schaffler MB, Frikha-Benayed D, Rosen CJ, Werner H, Kopchick JJ, Pavlov EV, Abramov AY, Yakar S.

J Bone Miner Res. 2018 Sep 14. doi: 10.1002/jbmr.3573. [Epub ahead of print]


Standardizing protocols dealing with growth hormone receptor gene disruption in mice using the Cre-lox system.

Duran-Ortiz S, Bell S, Kopchick JJ.

Growth Horm IGF Res. 2018 Aug 29;42-43:52-57. doi: 10.1016/j.ghir.2018.08.003. [Epub ahead of print]


Growth hormone activated STAT5 is required for induction of beige fat in vivo.

Nelson CN, List EO, Ieremia M, Constantin L, Chhabra Y, Kopchick JJ, Waters MJ.

Growth Horm IGF Res. 2018 Aug 29;42-43:40-51. doi: 10.1016/j.ghir.2018.08.004. [Epub ahead of print]


Transcriptional profiling identifies strain-specific effects of caloric restriction and opposite responses in human and mouse white adipose tissue.

Swindell WR, List EO, Berryman DE, Kopchick JJ.

Aging (Albany NY). 2018 Apr 29;10(4):701-746. doi: 10.18632/aging.101424.


Growth Hormone Research Society perspective on biomarkers of GH action in children and adults.

Johannsson G, Bidlingmaier M, Biller BMK, Boguszewski M, Casanueva FF, Chanson P, Clayton PE, Choong CS, Clemmons D, Dattani M, Frystyk J, Ho K, Hoffman AR, Horikawa R, Juul A, Kopchick JJ, Luo X, Neggers S, Netchine I, Olsson DS, Radovick S, Rosenfeld R, Ross RJ, Schilbach K, Solberg P, Strasburger C, Trainer P, Yuen KCJ, Wickstrom K, Jorgensen JOL; Growth Hormone Research Society.

Endocr Connect. 2018 Mar;7(3):R126-R134. doi: 10.1530/EC-18-0047. Epub 2018 Feb 26. Review.


MECHANISMS IN ENDOCRINOLOGY: Lessons from growth hormone receptor gene-disrupted mice: are there benefits of endocrine defects?

Basu R, Qian Y, Kopchick JJ.

Eur J Endocrinol. 2018 May;178(5):R155-R181. doi: 10.1530/EJE-18-0018. Epub 2018 Feb 19. Review.


Depot-specific and GH-dependent regulation of IGF binding protein-4, pregnancy-associated plasma protein-A, and stanniocalcin-2 in murine adipose tissue.

Hjortebjerg R, Berryman DE, Comisford R, List EO, Oxvig C, Bjerre M, Frystyk J, Kopchick JJ.

Growth Horm IGF Res. 2018 Apr;39:54-61. doi: 10.1016/j.ghir.2018.01.001. Epub 2018 Feb 3.


Effects of rapamycin on growth hormone receptor knockout mice.

Fang Y, Hill CM, Darcy J, Reyes-Ordoñez A, Arauz E, McFadden S, Zhang C, Osland J, Gao J, Zhang T, Frank SJ, Javors MA, Yuan R, Kopchick JJ, Sun LY, Chen J, Bartke A.

Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1495-E1503. doi: 10.1073/pnas.1717065115. Epub 2018 Jan 29.


Increased fibrosis: A novel means by which GH influences white adipose tissue function.

Householder LA, Comisford R, Duran-Ortiz S, Lee K, Troike K, Wilson C, Jara A, Harberson M, List EO, Kopchick JJ, Berryman DE.

Growth Horm IGF Res. 2018 Apr;39:45-53. doi: 10.1016/j.ghir.2017.12.010. Epub 2017 Dec 20.


Disruption of the GH receptor gene in adult mice and in insulin sensitive tissues.

Duran-Ortiz S, Noboa V, Kopchick JJ.

Growth Horm IGF Res. 2018 Feb;38:3-7. doi: 10.1016/j.ghir.2017.11.003. Epub 2017 Nov 24. Review.


Growth Hormone and the Epithelial-to-Mesenchymal Transition.

Brittain AL, Basu R, Qian Y, Kopchick JJ.

J Clin Endocrinol Metab. 2017 Oct 1;102(10):3662-3673. doi: 10.1210/jc.2017-01000. Review.


Mice overexpressing growth hormone exhibit increased skeletal muscle myostatin and MuRF1 with attenuation of muscle mass.

Consitt LA, Saneda A, Saxena G, List EO, Kopchick JJ.

Skelet Muscle. 2017 Sep 4;7(1):17. doi: 10.1186/s13395-017-0133-y.


Meeting Reports: The 25th Anniversary of the Growth Hormone Research Society Lisbon, Portugal, May 20, 2017.

Kopchick JJ, Johannsson G.

Pediatr Endocrinol Rev. 2017 Sep;15(1):53-56. doi: 10.17458/ No abstract available.


The impact of growth hormone on proteomic profiles: a review of mouse and adult human studies.

Duran-Ortiz S, Brittain AL, Kopchick JJ.

Clin Proteomics. 2017 Jun 29;14:24. doi: 10.1186/s12014-017-9160-2. eCollection 2017. Review.


Impact of Growth Hormone on Regulation of Adipose Tissue.

Troike KM, Henry BE, Jensen EA, Young JA, List EO, Kopchick JJ, Berryman DE.

Compr Physiol. 2017 Jun 18;7(3):819-840. doi: 10.1002/cphy.c160027. Review.


Hypothalamic-Pituitary Axis Regulates Hydrogen Sulfide Production.

Hine C, Kim HJ, Zhu Y, Harputlugil E, Longchamp A, Matos MS, Ramadoss P, Bauerle K, Brace L, Asara JM, Ozaki CK, Cheng SY, Singha S, Ahn KH, Kimmelman A, Fisher FM, Pissios P, Withers DJ, Selman C, Wang R, Yen K, Longo VD, Cohen P, Bartke A, Kopchick JJ, Miller R, Hollenberg AN, Mitchell JR.

Cell Metab. 2017 Jun 6;25(6):1320-1333.e5. doi: 10.1016/j.cmet.2017.05.003.


Differential effects of early-life nutrient restriction in long-lived GHR-KO and normal mice.

Fang Y, McFadden S, Darcy J, Hill CM, Huber JA, Verhulst S, Kopchick JJ, Miller RA, Sun LY, Bartke A.

Geroscience. 2017 Jun;39(3):347-356. doi: 10.1007/s11357-017-9978-6. Epub 2017 May 18.


Growth Hormone Resistance-Special Focus on Inflammatory Bowel Disease.

Soendergaard C, Young JA, Kopchick JJ.

Int J Mol Sci. 2017 May 9;18(5). pii: E1019. doi: 10.3390/ijms18051019. Review.


Ablation of Hepatic Production of the Acid-Labile Subunit in Bovine-GH Transgenic Mice: Effects on Organ and Skeletal Growth.

Liu Z, Han T, Fishman S, Butler J, Zimmermann T, Tremblay F, Harbison C, Agrawal N, Kopchick JJ, Schaffler MB, Yakar S.

Endocrinology. 2017 Aug 1;158(8):2556-2571. doi: 10.1210/en.2016-1952.


Hypothalamic growth hormone receptor (GHR) controls hepatic glucose production in nutrient-sensing leptin receptor (LepRb) expressing neurons.

Cady G, Landeryou T, Garratt M, Kopchick JJ, Qi N, Garcia-Galiano D, Elias CF, Myers MG Jr, Miller RA, Sandoval DA, Sadagurski M.

Mol Metab. 2017 Mar 16;6(5):393-405. doi: 10.1016/j.molmet.2017.03.001. eCollection 2017 May.


Spatial learning and memory in male mice with altered growth hormone action.

Basu A, McFarlane HG, Kopchick JJ.

Horm Behav. 2017 Jul;93:18-30. doi: 10.1016/j.yhbeh.2017.04.001. Epub 2017 Apr 25.


Insulin, IGF-1, and GH Receptors Are Altered in an Adipose Tissue Depot-Specific Manner in Male Mice With Modified GH Action.

Hjortebjerg R, Berryman DE, Comisford R, Frank SJ, List EO, Bjerre M, Frystyk J, Kopchick JJ.

Endocrinology. 2017 May 1;158(5):1406-1418. doi: 10.1210/en.2017-00084.


The role of transplanted visceral fat from the long-lived growth hormone receptor knockout mice on insulin signaling.

Bennis MT, Schneider A, Victoria B, Do A, Wiesenborn DS, Spinel L, Gesing A, Kopchick JJ, Siddiqi SA, Masternak MM.

Geroscience. 2017 Feb;39(1):51-59. doi: 10.1007/s11357-017-9957-y. Epub 2017 Jan 18.


Growth Hormone Receptor Knockdown Sensitizes Human Melanoma Cells to Chemotherapy by Attenuating Expression of ABC Drug Efflux Pumps.

Basu R, Baumgaertel N, Wu S, Kopchick JJ.

Horm Cancer. 2017 Jun;8(3):143-156. doi: 10.1007/s12672-017-0292-7. Epub 2017 Mar 14.


Diet-induced weight loss is sufficient to reduce senescent cell number in white adipose tissue of weight-cycled mice.

List EO, Jensen E, Kowalski J, Buchman M, Berryman DE, Kopchick JJ.

Nutr Healthy Aging. 2016 Oct 27;4(1):95-99. doi: 10.3233/NHA-1614.


Disruption of the GH Receptor Gene in Adult Mice Increases Maximal Lifespan in Females.

Junnila RK, Duran-Ortiz S, Suer O, Sustarsic EG, Berryman DE, List EO, Kopchick JJ.

Endocrinology. 2016 Dec;157(12):4502-4513. Epub 2016 Oct 12.


A Long-lived Mouse Lacking Both Growth Hormone and Growth Hormone Receptor: A New Animal Model for Aging Studies.

Gesing A, Wiesenborn D, Do A, Menon V, Schneider A, Victoria B, Stout MB, Kopchick JJ, Bartke A, Masternak MM.

J Gerontol A Biol Sci Med Sci. 2017 Aug 1;72(8):1054-1061. doi: 10.1093/gerona/glw193.


Fibroblast growth factor 21, fibroblast growth factor receptor 1, and β-Klotho expression in bovine growth hormone transgenic and growth hormone receptor knockout mice.

Brooks NE, Hjortebjerg R, Henry BE, List EO, Kopchick JJ, Berryman DE.

Growth Horm IGF Res. 2016 Oct - Dec;30-31:22-30. doi: 10.1016/j.ghir.2016.08.003. Epub 2016 Aug 24.


Growth hormone, insulin-like growth factor system and carcinogenesis.

Boguszewski CL, Boguszewski MC, Kopchick JJ.

Endokrynol Pol. 2016;67(4):414-26. doi: 10.5603/EP.a2016.0053. Epub 2016 Jul 8. Review.


Enhanced Cognition and Hypoglutamatergic Signaling in a Growth Hormone Receptor Knockout Mouse Model of Successful Aging.

Hascup KN, Lynn MK, Fitzgerald PJ, Randall S, Kopchick JJ, Boger HA, Bartke A, Hascup ER.

J Gerontol A Biol Sci Med Sci. 2017 Mar 1;72(3):329-337. doi: 10.1093/gerona/glw088.


Jens Sandahl Christiansen, DMSci, FRCPI (1948-2015).

Jørgensen JO, Kopchick JJ, Bengtsson BÅ, Kappelgaard AM.

Pediatr Endocrinol Rev. 2016 Mar;13(3):567. No abstract available.


Cardiac-Specific Disruption of GH Receptor Alters Glucose Homeostasis While Maintaining Normal Cardiac Performance in Adult Male Mice.

Jara A, Liu X, Sim D, Benner CM, Duran-Ortiz S, Qian Y, List EO, Berryman DE, Kim JK, Kopchick JJ.

Endocrinology. 2016 May;157(5):1929-41. doi: 10.1210/en.2015-1686. Epub 2016 Apr 1.


Growth Hormone Research Society perspective on the development of long-acting growth hormone preparations.

Christiansen JS, Backeljauw PF, Bidlingmaier M, Biller BM, Boguszewski MC, Casanueva FF, Chanson P, Chatelain P, Choong CS, Clemmons DR, Cohen LE, Cohen P, Frystyk J, Grimberg A, Hasegawa Y, Haymond MW, Ho K, Hoffman AR, Holly JM, Horikawa R, Höybye C, Jorgensen JO, Johannsson G, Juul A, Katznelson L, Kopchick JJ, Lee KO, Lee KW, Luo X, Melmed S, Miller BS, Misra M, Popovic V, Rosenfeld RG, Ross J, Ross RJ, Saenger P, Strasburger CJ, Thorner MO, Werner H, Yuen K.

Eur J Endocrinol. 2016 Jun;174(6):C1-8. doi: 10.1530/EJE-16-0111. Epub 2016 Mar 23.


Growth Hormone Influence on the Morphology and Size of the Mouse Meibomian Gland.

Liu Y, Knop E, Knop N, Sullivan DA, List EO, Kopchick JJ, Kam WR, Ding J.

J Ophthalmol. 2016;2016:5728071. doi: 10.1155/2016/5728071. Epub 2016 Feb 14.


Tissue-Specific Suppression of Thyroid Hormone Signaling in Various Mouse Models of Aging.

Visser WE, Bombardieri CR, Zevenbergen C, Barnhoorn S, Ottaviani A, van der Pluijm I, Brandt R, Kaptein E, van Heerebeek R, van Toor H, Garinis GA, Peeters RP, Medici M, van Ham W, Vermeij WP, de Waard MC, de Krijger RR, Boelen A, Kwakkel J, Kopchick JJ, List EO, Melis JP, Darras VM, Dollé ME, van der Horst GT, Hoeijmakers JH, Visser TJ.

PLoS One. 2016 Mar 8;11(3):e0149941. doi: 10.1371/journal.pone.0149941. eCollection 2016.


Deconstructing the Growth Hormone Receptor(GHR): Physical and Metabolic Phenotypes of Tissue-Specific GHR Gene-Disrupted Mice.

Young JA, List EO, Kopchick JJ.

Prog Mol Biol Transl Sci. 2016;138:27-39. doi: 10.1016/bs.pmbts.2015.10.014. Epub 2016 Jan 13. Review.


The somatotropic axis and aging: Benefits of endocrine defects.

Bartke A, List EO, Kopchick JJ.

Growth Horm IGF Res. 2016 Apr;27:41-45. doi: 10.1016/j.ghir.2016.02.002. Epub 2016 Feb 16. Review.


Growth Hormone Receptor Deficiency Protects against Age-Related NLRP3 Inflammasome Activation and Immune Senescence.

Spadaro O, Goldberg EL, Camell CD, Youm YH, Kopchick JJ, Nguyen KY, Bartke A, Sun LY, Dixit VD.

Cell Rep. 2016 Feb 23;14(7):1571-1580. doi: 10.1016/j.celrep.2016.01.044. Epub 2016 Feb 11.


Prof. Jens Sandahl Christiansen.

Jørgensen JO, Kopchick JJ, Bengtsson BÅ, Kappelgaard AM.

Pituitary. 2016 Apr;19(2):115-6. doi: 10.1007/s11102-016-0705-6. No abstract available.


Developments in our understanding of the effects of growth hormone on white adipose tissue from mice: implications to the clinic.

Berryman DE, Henry B, Hjortebjerg R, List EO, Kopchick JJ.

Expert Rev Endocrinol Metab. 2016;11(2):197-207. doi: 10.1586/17446651.2016.1147950. Epub 2016 Feb 24.


Young at Heart.

Jara A, Kopchick JJ.

Endocrinology. 2016 Jan;157(1):44-5. doi: 10.1210/en.2015-1977. No abstract available.


Transcriptome profiling reveals divergent expression shifts in brown and white adipose tissue from long-lived GHRKO mice.

Stout MB, Swindell WR, Zhi X, Rohde K, List EO, Berryman DE, Kopchick JJ, Gesing A, Fang Y, Masternak MM.

Oncotarget. 2015 Sep 29;6(29):26702-15. doi: 10.18632/oncotarget.5760.


Growth Hormone Receptor Antagonist Transgenic Mice Have Increased Subcutaneous Adipose Tissue Mass, Altered Glucose Homeostasis and No Change in White Adipose Tissue Cellular Senescence.

Comisford R, Lubbers ER, Householder LA, Suer O, Tchkonia T, Kirkland JL, List EO, Kopchick JJ, Berryman DE.

Gerontology. 2016;62(2):163-72. doi: 10.1159/000439050. Epub 2015 Sep 16.


Growth hormone modulates hypothalamic inflammation in long-lived pituitary dwarf mice.

Sadagurski M, Landeryou T, Cady G, Kopchick JJ, List EO, Berryman DE, Bartke A, Miller RA.

Aging Cell. 2015 Dec;14(6):1045-54. doi: 10.1111/acel.12382. Epub 2015 Aug 12.


Removal of growth hormone receptor (GHR) in muscle of male mice replicates some of the health benefits seen in global GHR-/- mice.

List EO, Berryman DE, Ikeno Y, Hubbard GB, Funk K, Comisford R, Young JA, Stout MB, Tchkonia T, Masternak MM, Bartke A, Kirkland JL, Miller RA, Kopchick JJ.

Aging (Albany NY). 2015 Jul;7(7):500-12.

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