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Mater Sci Eng C Mater Biol Appl. 2014 Aug 1;41:301-8. doi: 10.1016/j.msec.2014.04.045. Epub 2014 May 2.

Synthesis, characterization and foaming of PHEA-PLLA, a new graft copolymer for biomedical engineering.

Author information

1
Department of Civil, Environmental, Aerospace, Materials Engineering, University of Palermo, 90142, Palermo, Italy. Electronic address: francesco.carfipavia@unipa.it.
2
Department of Civil, Environmental, Aerospace, Materials Engineering, University of Palermo, 90142, Palermo, Italy.
3
Dipartimento di Scienze e Tecnologie Molecolari e Biomolecolari, Sezione di Chimica e Tecnologie Farmaceutiche, University of Palermo, Italy.

Abstract

In this study a chemical grafting procedure was set up in order to link high molecular weight poly L-lactic acid (PLLA) chains to the hydrophilic α,β-poly(N-2-hydroxyethyl)-DL-aspartamide (PHEA) backbone. A graft copolymer named PHEA-g-PLLA (or simply PHEA-PLLA) was obtained bearing a degree of derivatization of 1.0 mol.% of PLLA as grafted chain. This new hybrid derivative offers both the opportune crystallinity necessary for the production of scaffolds trough a thermally induced phase separation (TIPS) technique and the proper chemical reactivity to perform further functionalizations with bio-effectors and drugs. PHEA-PLLA porous scaffolds for tissue engineering applications were successfully obtained via TIPS and characterized. Structures with an open porosity and a good level of interconnection were detected. As the applicability of the scaffold is mainly dependent on its pore size, preliminary studies about the mechanisms governing scaffold's pore diameter were carried out.

KEYWORDS:

Poly-L-lactic acid; Polymer graft; Scaffold; Thermally induced phase separation

PMID:
24907764
DOI:
10.1016/j.msec.2014.04.045
[Indexed for MEDLINE]

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