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Items: 40

1.

Cerebro-Cerebellar Functional Connectivity is Associated with Cerebellar Excitation-Inhibition Balance in Autism Spectrum Disorder.

Hegarty JP 2nd, Weber DJ, Cirstea CM, Beversdorf DQ.

J Autism Dev Disord. 2018 Oct;48(10):3460-3473. doi: 10.1007/s10803-018-3613-y.

PMID:
29796960
2.

Cationic amphiphilic bolaamphiphile-based delivery of antisense oligonucleotides provides a potentially microbiome sparing treatment for C. difficile.

Sharma AK, Krzeminski J, Weissig V, Hegarty JP, Stewart DB.

J Antibiot (Tokyo). 2018 Aug;71(8):713-721. doi: 10.1038/s41429-018-0056-9. Epub 2018 Apr 19.

PMID:
29674636
3.

Antibiotic Treatments for Clostridium difficile Infection Are Associated with Distinct Bacterial and Fungal Community Structures.

Lamendella R, Wright JR, Hackman J, McLimans C, Toole DR, Bernard Rubio W, Drucker R, Wong HT, Sabey K, Hegarty JP, Stewart DB Sr.

mSphere. 2018 Jan 10;3(1). pii: e00572-17. doi: 10.1128/mSphere.00572-17. eCollection 2018 Jan-Feb.

4.

Advances in therapeutic bacterial antisense biotechnology.

Hegarty JP, Stewart DB Sr.

Appl Microbiol Biotechnol. 2018 Feb;102(3):1055-1065. doi: 10.1007/s00253-017-8671-0. Epub 2017 Dec 5. Review.

PMID:
29209794
5.

A proton MR spectroscopy study of the thalamus in twins with autism spectrum disorder.

Hegarty JP 2nd, Gu M, Spielman DM, Cleveland SC, Hallmayer JF, Lazzeroni LC, Raman MM, Frazier TW, Phillips JM, Reiss AL, Hardan AY.

Prog Neuropsychopharmacol Biol Psychiatry. 2018 Feb 2;81:153-160. doi: 10.1016/j.pnpbp.2017.09.016. Epub 2017 Sep 21.

PMID:
28941767
6.

The Microbial Ecosystem Distinguishes Chronically Diseased Tissue from Adjacent Tissue in the Sigmoid Colon of Chronic, Recurrent Diverticulitis Patients.

Schieffer KM, Sabey K, Wright JR, Toole DR, Drucker R, Tokarev V, Harris LR, Deiling S, Eshelman MA, Hegarty JP, Yochum GS, Koltun WA, Lamendella R, Stewart DB Sr.

Sci Rep. 2017 Aug 16;7(1):8467. doi: 10.1038/s41598-017-06787-8.

7.

Genetic association and epistatic interaction of the interleukin-10 signaling pathway in pediatric inflammatory bowel disease.

Lin Z, Wang Z, Hegarty JP, Lin TR, Wang Y, Deiling S, Wu R, Thomas NJ, Floros J.

World J Gastroenterol. 2017 Jul 21;23(27):4897-4909. doi: 10.3748/wjg.v23.i27.4897.

8.

Association of the haem oxygenase-1 gene with inflammatory bowel disease.

Lin Z, Hao H, Hegarty JP, Lin TR, Wang Y, Harris LR, Xu HN, Wu R, Thomas NJ, Floros J.

Swiss Med Wkly. 2017 Aug 2;147:w14456. doi: 10.4414/smw.2017.14456. eCollection 2017.

9.

Beta-adrenergic antagonism modulates functional connectivity in the default mode network of individuals with and without autism spectrum disorder.

Hegarty JP 2nd, Ferguson BJ, Zamzow RM, Rohowetz LJ, Johnson JD, Christ SE, Beversdorf DQ.

Brain Imaging Behav. 2017 Oct;11(5):1278-1289. doi: 10.1007/s11682-016-9604-8.

PMID:
27714553
10.

Bolaamphiphile-based nanocomplex delivery of phosphorothioate gapmer antisense oligonucleotides as a treatment for Clostridium difficile.

Hegarty JP, Krzeminski J, Sharma AK, Guzman-Villanueva D, Weissig V, Stewart DB Sr.

Int J Nanomedicine. 2016 Aug 1;11:3607-19. doi: 10.2147/IJN.S109600. eCollection 2016.

11.

Induction and Purification of C. difficile Phage Tail-Like Particles.

Hegarty JP, Sangster W, Ashley RE, Myers R, Hafenstein S, Stewart DB Sr.

Methods Mol Biol. 2016;1476:167-75. doi: 10.1007/978-1-4939-6361-4_12.

PMID:
27507340
12.

Bacterial and Fungal Microbiota Changes Distinguish C. difficile Infection from Other Forms of Diarrhea: Results of a Prospective Inpatient Study.

Sangster W, Hegarty JP, Schieffer KM, Wright JR, Hackman J, Toole DR, Lamendella R, Stewart DB Sr.

Front Microbiol. 2016 May 25;7:789. doi: 10.3389/fmicb.2016.00789. eCollection 2016.

13.

Morphological differences in the lateral geniculate nucleus associated with dyslexia.

Giraldo-Chica M, Hegarty JP 2nd, Schneider KA.

Neuroimage Clin. 2015 Mar 20;7:830-6. doi: 10.1016/j.nicl.2015.03.011. eCollection 2015.

14.

Characterization of Clostridium difficile isolates from human fecal samples and retail meat from Pennsylvania.

Varshney JB, Very KJ, Williams JL, Hegarty JP, Stewart DB, Lumadue J, Venkitanarayanan K, Jayarao BM.

Foodborne Pathog Dis. 2014 Oct;11(10):822-9. doi: 10.1089/fpd.2014.1790.

PMID:
25269079
15.

An interleukin-4 polymorphism is associated with susceptibility to Clostridium difficile infection in patients with inflammatory bowel disease: results of a retrospective cohort study.

Connelly TM, Koltun WA, Sangster W, Berg AS, Hegarty JP, Harris L 3rd, Deiling S, Stewart DB.

Surgery. 2014 Oct;156(4):769-74. doi: 10.1016/j.surg.2014.06.067.

PMID:
25239315
16.

Proton pump inhibitors induce changes in colonocyte gene expression that may affect Clostridium difficile infection.

Hegarty JP, Sangster W, Harris LR 3rd, Stewart DB.

Surgery. 2014 Oct;156(4):972-8. doi: 10.1016/j.surg.2014.06.074. Epub 2014 Aug 21.

PMID:
25151556
17.

Phage tail-like particles kill Clostridium difficile and represent an alternative to conventional antibiotics.

Sangster W, Hegarty JP, Stewart DB Sr.

Surgery. 2015 Jan;157(1):96-103. doi: 10.1016/j.surg.2014.06.015. Epub 2014 Jul 22.

PMID:
25061002
18.

Ulcerative colitis neoplasia is not associated with common inflammatory bowel disease single-nucleotide polymorphisms.

Connelly TM, Berg AS, Harris LR 3rd, Brinton DL, Hegarty JP, Deiling SM, Stewart DB, Koltun WA.

Surgery. 2014 Aug;156(2):253-62. doi: 10.1016/j.surg.2014.03.017. Epub 2014 Mar 14.

PMID:
24947639
19.

The TNFSF15 gene single nucleotide polymorphism rs7848647 is associated with surgical diverticulitis.

Connelly TM, Berg AS, Hegarty JP, Deiling S, Brinton D, Poritz LS, Koltun WA.

Ann Surg. 2014 Jun;259(6):1132-7. doi: 10.1097/SLA.0000000000000232.

PMID:
24814505
20.

T-cell activation Rho GTPase-activating protein expression varies with inflammation location and severity in Crohn's disease.

Connelly TM, Berg AS, Harris LR 3rd, Hegarty JP, Ruggiero FM, Deiling SM, Brinton DL, Koltun WA.

J Surg Res. 2014 Aug;190(2):457-64. doi: 10.1016/j.jss.2014.01.019. Epub 2014 Jan 17.

PMID:
24582067
21.

Single nucleotide polymorphisms of the tcdC gene and presence of the binary toxin gene predict recurrent episodes of Clostridium difficile infection.

Stewart DB, Berg AS, Hegarty JP.

Ann Surg. 2014 Aug;260(2):299-304. doi: 10.1097/SLA.0000000000000469.

PMID:
24374512
22.

A single nucleotide polymorphism in the STAT5 gene favors colonic as opposed to small-bowel inflammation in Crohn's disease.

Connelly TM, Koltun WA, Berg AS, Hegarty JP, Brinton D, Deiling S, Poritz LS, Stewart DB.

Dis Colon Rectum. 2013 Sep;56(9):1068-74. doi: 10.1097/DCR.0b013e31829de128.

PMID:
23929016
23.

Correlation between virulence gene expression and proton pump inhibitors and ambient pH in Clostridium difficile: results of an in vitro study.

Stewart DB, Hegarty JP.

J Med Microbiol. 2013 Oct;62(Pt 10):1517-23. doi: 10.1099/jmm.0.059709-0. Epub 2013 Jun 25. Erratum in: J Med Microbiol. 2013 Dec;62(Pt 12):1919.

PMID:
23800596
24.

NOD2 mutations affect muramyl dipeptide stimulation of human B lymphocytes and interact with other IBD-associated genes.

Lin Z, Hegarty JP, John G, Berg A, Wang Z, Sehgal R, Pastor DM, Wang Y, Harris LR 3rd, Poritz LS, Schreiber S, Koltun WA.

Dig Dis Sci. 2013 Sep;58(9):2599-607. doi: 10.1007/s10620-013-2696-8. Epub 2013 May 26.

PMID:
23709157
25.

Mutation in TAGAP is protective of anal sepsis in ileocolic Crohn's disease.

Connelly TM, Sehgal R, Berg AS, Hegarty JP, Deiling S, Stewart DB, Poritz LS, Koltun WA.

Dis Colon Rectum. 2012 Nov;55(11):1145-52. doi: 10.1097/DCR.0b013e3182676931.

PMID:
23044675
26.

Identification of disease-associated DNA methylation in B cells from Crohn's disease and ulcerative colitis patients.

Lin Z, Hegarty JP, Yu W, Cappel JA, Chen X, Faber PW, Wang Y, Poritz LS, Fan JB, Koltun WA.

Dig Dis Sci. 2012 Dec;57(12):3145-53. doi: 10.1007/s10620-012-2288-z. Epub 2012 Jul 21.

PMID:
22821069
27.

Genetic risk profiling and gene signature modeling to predict risk of complications after IPAA.

Sehgal R, Berg A, Polinski JI, Hegarty JP, Lin Z, McKenna KJ, Stewart DB, Poritz LS, Koltun WA.

Dis Colon Rectum. 2012 Mar;55(3):239-48. doi: 10.1097/DCR.0b013e31823e2d18.

PMID:
22469789
28.

PTPN2 is associated with Crohn's disease and its expression is regulated by NKX2-3.

Yu W, Hegarty JP, Berg A, Kelly AA, Wang Y, Poritz LS, Franke A, Schreiber S, Koltun WA, Lin Z.

Dis Markers. 2012;32(2):83-91. doi: 10.3233/DMA-2011-0867.

29.

Mutations in IRGM are associated with more frequent need for surgery in patients with ileocolonic Crohn's disease.

Sehgal R, Berg A, Polinski JI, Hegarty JP, Lin Z, McKenna KJ, Stewart DB, Poritz LS, Koltun WA.

Dis Colon Rectum. 2012 Feb;55(2):115-21. doi: 10.1097/DCR.0b013e31823ccea8.

PMID:
22228152
30.

DLG5 P1371Q is associated with inflammatory bowel disease and complementary to R30Q in disease susceptibility.

Lin Z, Hegarty JP, Berb A, Wang Z, Kelly AA, Wang Y, Poritz LS, Wu R, Koltun WA.

Swiss Med Wkly. 2011 Nov 8;141:w13290. doi: 10.4414/smw.2011.13290. eCollection 2011.

31.

Genes differentially regulated by NKX2-3 in B cells between ulcerative colitis and Crohn's disease patients and possible involvement of EGR1.

Yu W, Lin Z, Hegarty JP, Chen X, Kelly AA, Wang Y, Poritz LS, Koltun WA.

Inflammation. 2012 Jun;35(3):889-99. doi: 10.1007/s10753-011-9390-9.

PMID:
21968973
32.

NKX2-3 variant rs11190140 is associated with IBD and alters binding of NFAT.

John G, Hegarty JP, Yu W, Berg A, Pastor DM, Kelly AA, Wang Y, Poritz LS, Schreiber S, Koltun WA, Lin Z.

Mol Genet Metab. 2011 Sep-Oct;104(1-2):174-9. doi: 10.1016/j.ymgme.2011.06.023. Epub 2011 Jul 6.

PMID:
21803625
33.

Genetic variants and monoallelic expression of surfactant protein-D in inflammatory bowel disease.

Lin Z, John G, Hegarty JP, Berg A, Yu W, Wang Y, Kelly AA, Peterson BZ, Poritz LS, Floros J, Koltun WA.

Ann Hum Genet. 2011 Sep;75(5):559-68. doi: 10.1111/j.1469-1809.2011.00662.x. Epub 2011 Jul 25.

34.

NKX2-3 transcriptional regulation of endothelin-1 and VEGF signaling in human intestinal microvascular endothelial cells.

Yu W, Hegarty JP, Berg A, Chen X, West G, Kelly AA, Wang Y, Poritz LS, Koltun WA, Lin Z.

PLoS One. 2011;6(5):e20454. doi: 10.1371/journal.pone.0020454. Epub 2011 May 26.

35.

Failure of anakinra treatment of pyoderma gangrenosum in an IBD patient and relevance to the PSTPIP1 gene.

Lin Z, Hegarty JP, Lin T, Ostrov B, Wang Y, Yu W, Kelly AA, Poritz LS, Koltun WA.

Inflamm Bowel Dis. 2011 Jun;17(6):E41-2. doi: 10.1002/ibd.21684. Epub 2011 Mar 15. No abstract available.

PMID:
21438098
36.

NOD2/CARD15 mutations correlate with severe pouchitis after ileal pouch-anal anastomosis.

Sehgal R, Berg A, Hegarty JP, Kelly AA, Lin Z, Poritz LS, Koltun WA.

Dis Colon Rectum. 2010 Nov;53(11):1487-94. doi: 10.1007/DCR.0b013e3181f22635.

PMID:
20940596
37.

Genes regulated by Nkx2-3 in siRNA-mediated knockdown B cells: implication of endothelin-1 in inflammatory bowel disease.

Yu W, Lin Z, Hegarty JP, John G, Chen X, Faber PW, Kelly AA, Wang Y, Poritz LS, Schreiber S, Koltun WA.

Mol Genet Metab. 2010 May;100(1):88-95. doi: 10.1016/j.ymgme.2010.02.001. Epub 2010 Feb 6.

PMID:
20188614
38.

Genes regulated by Nkx2-3 in sporadic and inflammatory bowel disease-associated colorectal cancer cell lines.

Yu W, Lin Z, Pastor DM, Hegarty JP, Chen X, Kelly AA, Wang Y, Poritz LS, Koltun WA.

Dig Dis Sci. 2010 Nov;55(11):3171-80. doi: 10.1007/s10620-010-1138-0. Epub 2010 Feb 18.

PMID:
20165982
39.

Association of a Nkx2-3 polymorphism with Crohn's disease and expression of Nkx2-3 is up-regulated in B cell lines and intestinal tissues with Crohn's disease.

Yu W, Lin Z, Kelly AA, Hegarty JP, Poritz LS, Wang Y, Li T, Schreiber S, Koltun WA.

J Crohns Colitis. 2009 Sep;3(3):189-95. doi: 10.1016/j.crohns.2009.04.003. Epub 2009 Jun 10.

PMID:
21172269
40.

Effect of oxidizing disinfectants (chlorine, monochloramine, and ozone) on Helicobacter pylori.

Baker KH, Hegarty JP, Redmond B, Reed NA, Herson DS.

Appl Environ Microbiol. 2002 Feb;68(2):981-4.

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