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Items: 1 to 20 of 41

1.

Comparative Error-Free and Error-Prone Translesion Synthesis of N(2)-2'-Deoxyguanosine Adducts Formed by Mitomycin C and Its Metabolite, 2,7-Diaminomitosene, in Human Cells.

Bose A, Surugihalli C, Pande P, Champeil E, Basu AK.

Chem Res Toxicol. 2016 May 16;29(5):933-9. doi: 10.1021/acs.chemrestox.6b00087. Epub 2016 Apr 27.

2.

Differential toxicity of DNA adducts of mitomycin C.

Bargonetti J, Champeil E, Tomasz M.

J Nucleic Acids. 2010 Jul 29;2010. pii: 698960. doi: 10.4061/2010/698960.

3.
4.

Mapping DNA adducts of mitomycin C and decarbamoyl mitomycin C in cell lines using liquid chromatography/ electrospray tandem mass spectrometry.

Paz MM, Ladwa S, Champeil E, Liu Y, Rockwell S, Boamah EK, Bargonetti J, Callahan J, Roach J, Tomasz M.

Chem Res Toxicol. 2008 Dec;21(12):2370-8. doi: 10.1021/tx8002615.

5.

Synthesis of an oligodeoxyribonucleotide adduct of mitomycin C by the postoligomerization method via a triamino mitosene.

Champeil E, Paz MM, Ladwa S, Clement CC, Zatorski A, Tomasz M.

J Am Chem Soc. 2008 Jul 23;130(29):9556-65. doi: 10.1021/ja802118p. Epub 2008 Jun 28.

7.

DNA adduct of the mitomycin C metabolite 2,7-diaminomitosene is a nontoxic and nonmutagenic DNA lesion in vitro and in vivo.

Utzat CD, Clement CC, Ramos LA, Das A, Tomasz M, Basu AK.

Chem Res Toxicol. 2005 Feb;18(2):213-23.

PMID:
15720125
8.

Relative toxicities of DNA cross-links and monoadducts: new insights from studies of decarbamoyl mitomycin C and mitomycin C.

Palom Y, Suresh Kumar G, Tang LQ, Paz MM, Musser SM, Rockwell S, Tomasz M.

Chem Res Toxicol. 2002 Nov;15(11):1398-406.

PMID:
12437330
9.

Differential activation of p53 by the various adducts of mitomycin C.

Abbas T, Olivier M, Lopez J, Houser S, Xiao G, Kumar GS, Tomasz M, Bargonetti J.

J Biol Chem. 2002 Oct 25;277(43):40513-9. Epub 2002 Aug 14.

10.

Molecular basis of mitomycin C resistance in streptomyces: structure and function of the MRD protein.

Martin TW, Dauter Z, Devedjiev Y, Sheffield P, Jelen F, He M, Sherman DH, Otlewski J, Derewenda ZS, Derewenda U.

Structure. 2002 Jul;10(7):933-42.

11.

Solution structure of a guanine-N7-linked complex of the mitomycin C metabolite 2,7-diaminomitosene and DNA. Basis of sequence selectivity.

Subramaniam G, Paz MM, Suresh Kumar G, Das A, Palom Y, Clement CC, Patel DJ, Tomasz M.

Biochemistry. 2001 Sep 4;40(35):10473-84. Erratum in: Biochemistry 2001 Oct 23;40(42):12746.

PMID:
11523988
12.

Bioreductive metabolism of mitomycin C in EMT6 mouse mammary tumor cells: cytotoxic and non-cytotoxic pathways, leading to different types of DNA adducts. The effect of dicumarol.

Palom Y, Belcourt MF, Tang LQ, Mehta SS, Sartorelli AC, Pritsos CA, Pritsos KL, Rockwell S, Tomasz M.

Biochem Pharmacol. 2001 Jun 15;61(12):1517-29.

PMID:
11377381
13.
14.

Structure of adduct X, the last unknown of the six major DNA adducts of mitomycin C formed in EMT6 mouse mammary tumor cells.

Palom Y, Belcourt MF, Musser SM, Sartorelli AC, Rockwell S, Tomasz M.

Chem Res Toxicol. 2000 Jun;13(6):479-88.

PMID:
10858321
15.

Formation of a major DNA adduct of the mitomycin metabolite 2,7-diaminomitosene in EMT6 mouse mammary tumor cells treated with mitomycin C.

Palom Y, Belcourt MF, Kumar GS, Arai H, Kasai M, Sartorelli AC, Rockwell S, Tomasz M.

Oncol Res. 1998;10(10):509-21.

PMID:
10338154
16.

Pharmacological determinants of the antitumour activity of mitomycin C.

Spanswick VJ, Cummings J, Ritchie AA, Smyth JF.

Biochem Pharmacol. 1998 Dec 1;56(11):1497-503.

PMID:
9827584
17.

Mitomycin C-DNA adducts generated by DT-diaphorase. Revised mechanism of the enzymatic reductive activation of mitomycin C.

Suresh Kumar G, Lipman R, Cummings J, Tomasz M.

Biochemistry. 1997 Nov 18;36(46):14128-36.

PMID:
9369485
18.

Enzymology of mitomycin C metabolic activation in tumour tissue. Characterization of a novel mitochondrial reductase.

Spanswick VJ, Cummings J, Smyth JF.

Biochem Pharmacol. 1996 Jun 28;51(12):1623-30.

PMID:
8687477
19.

Noncovalent binding of a mitomycin C metabolite, 2,7-diaminomitosene, to duplex DNA.

Peterson DM, Fisher J, Beall HD, Ross D.

Cancer Lett. 1995 Apr 14;90(2):133-8.

PMID:
7736448
20.

Binding of 2,7-diaminomitosene to DNA: model for the precovalent recognition of DNA by activated mitomycin C.

Kumar GS, He QY, Behr-Ventura D, Tomasz M.

Biochemistry. 1995 Feb 28;34(8):2662-71.

PMID:
7873548

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