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  • Filters activated: Toxicology. Clear all to show 172 items.

Adverse effects of mefloquine for the treatment of uncomplicated malaria in Thailand: A pooled analysis of 19, 850 individual patients.

Lee SJ, Ter Kuile FO, Price RN, Luxemburger C, Nosten F.

PLoS One. 2017 Feb 13;12(2):e0168780. doi: 10.1371/journal.pone.0168780. eCollection 2017.


Comparison of artesunate-mefloquine and artemether-lumefantrine fixed-dose combinations for treatment of uncomplicated Plasmodium falciparum malaria in children younger than 5 years in sub-Saharan Africa: a randomised, multicentre, phase 4 trial.

Sirima SB, Ogutu B, Lusingu JPA, Mtoro A, Mrango Z, Ouedraogo A, Yaro JB, Onyango KO, Gesase S, Mnkande E, Ngocho JS, Ackermann I, Aubin F, Vanraes J, Strub N, Carn G.

Lancet Infect Dis. 2016 Oct;16(10):1123-1133. doi: 10.1016/S1473-3099(16)30020-2. Epub 2016 Jul 16.


Rubber workers on the front lines.

Roberts L.

Science. 2016 Apr 22;352(6284):404-5. doi: 10.1126/science.352.6284.404. Epub 2016 Apr 21. No abstract available.


No Clinical or Molecular Evidence of Plasmodium falciparum Resistance to Artesunate-Mefloquine in Northwestern Brazil.

Ladeia-Andrade S, de Melo GN, de Souza-Lima Rde C, Salla LC, Bastos MS, Rodrigues PT, Luz Fd, Ferreira MU.

Am J Trop Med Hyg. 2016 Jul 6;95(1):148-54. doi: 10.4269/ajtmh.16-0017. Epub 2016 Apr 11.


Four Artemisinin-Based Treatments in African Pregnant Women with Malaria.

PREGACT Study Group, Pekyi D, Ampromfi AA, Tinto H, Traoré-Coulibaly M, Tahita MC, Valéa I, Mwapasa V, Kalilani-Phiri L, Kalanda G, Madanitsa M, Ravinetto R, Mutabingwa T, Gbekor P, Tagbor H, Antwi G, Menten J, De Crop M, Claeys Y, Schurmans C, Van Overmeir C, Thriemer K, Van Geertruyden JP, D'Alessandro U, Nambozi M, Mulenga M, Hachizovu S, Kabuya JB, Mulenga J.

N Engl J Med. 2016 Mar 10;374(10):913-27. doi: 10.1056/NEJMoa1508606.


How Robust Are Malaria Parasite Clearance Rates as Indicators of Drug Effectiveness and Resistance?

Hastings IM, Kay K, Hodel EM.

Antimicrob Agents Chemother. 2015 Oct;59(10):6428-36. doi: 10.1128/AAC.00481-15. Epub 2015 Aug 3.


Safe and efficacious artemisinin-based combination treatments for African pregnant women with malaria: a multicentre randomized control trial.

Nambozi M, Mulenga M, Halidou T, Tagbor H, Mwapasa V, Phiri LK, Kalanda G, Valea I, Traore M, Mwakazanga D, Claeys Y, Schurmans C, De Crop M, Menten J, Ravinetto R, Thriemer K, Van Geertruyden JP, Mutabingwa T, D'Alessandro U; Pregact Group.

Reprod Health. 2015 Jan 15;12:5. doi: 10.1186/1742-4755-12-5.


Praziquantel, mefloquine-praziquantel, and mefloquine-artesunate-praziquantel against Schistosoma haematobium: a randomized, exploratory, open-label trial.

Keiser J, Silué KD, Adiossan LK, N'Guessan NA, Monsan N, Utzinger J, N'Goran EK.

PLoS Negl Trop Dis. 2014 Jul 17;8(7):e2975. doi: 10.1371/journal.pntd.0002975. eCollection 2014 Jul.


Novel anti-malarial combinations and their toxicity.

Angus B.

Expert Rev Clin Pharmacol. 2014 May;7(3):299-316. doi: 10.1586/17512433.2014.907523. Epub 2014 Apr 9. Review.


Comparative safety of artemether-lumefantrine and other artemisinin-based combinations in children: a systematic review.

Egunsola O, Oshikoya KA.

Malar J. 2013 Nov 1;12:385. doi: 10.1186/1475-2875-12-385. Review.


Antimalarial drug resistance in Bangladesh, 1996-2012.

Haque U, Glass GE, Haque W, Islam N, Roy S, Karim J, Noedl H.

Trans R Soc Trop Med Hyg. 2013 Dec;107(12):745-52. doi: 10.1093/trstmh/trt088. Epub 2013 Oct 14. Review.


Plasmodium falciparum Polymorphisms associated with ex vivo drug susceptibility and clinical effectiveness of artemisinin-based combination therapies in Benin.

Dahlström S, Aubouy A, Maïga-Ascofaré O, Faucher JF, Wakpo A, Ezinmègnon S, Massougbodji A, Houzé P, Kendjo E, Deloron P, Le Bras J, Houzé S.

Antimicrob Agents Chemother. 2014;58(1):1-10. doi: 10.1128/AAC.01790-12. Epub 2013 Oct 7.


Therapeutic efficacy of fixed dose artesunate-mefloquine for the treatment of acute, uncomplicated Plasmodium falciparum malaria in Kampong Speu, Cambodia.

Leang R, Ros S, Duong S, Navaratnam V, Lim P, Ariey F, Kiechel JR, Ménard D, Taylor WR.

Malar J. 2013 Sep 23;12:343. doi: 10.1186/1475-2875-12-343.



White NJ, Pukrittayakamee S, Hien TT, Faiz MA, Mokuolu OA, Dondorp AM.

Lancet. 2014 Feb 22;383(9918):723-35. doi: 10.1016/S0140-6736(13)60024-0. Epub 2013 Aug 15. Review.


Safety and efficacy of pyronaridine-artesunate in uncomplicated acute malaria: an integrated analysis of individual patient data from six randomized clinical trials.

Duparc S, Borghini-Fuhrer I, Craft CJ, Arbe-Barnes S, Miller RM, Shin CS, Fleckenstein L.

Malar J. 2013 Feb 21;12:70. doi: 10.1186/1475-2875-12-70.


Efficacy and tolerability of a new formulation of artesunate-mefloquine for the treatment of uncomplicated malaria in adult in Senegal: open randomized trial.

Tine RC, Faye B, Sylla K, Ndiaye JL, Ndiaye M, Sow D, Lo AC, Abiola A, Ba MC, Gaye O.

Malar J. 2012 Dec 12;11:416. doi: 10.1186/1475-2875-11-416.


Efficacy and safety of dihydroartemisinin-piperaquine for treatment of uncomplicated Plasmodium falciparum malaria in endemic countries: meta-analysis of randomised controlled studies.

Naing C, Mak JW, Aung K, Wong JY.

Trans R Soc Trop Med Hyg. 2013 Feb;107(2):65-73. doi: 10.1093/trstmh/trs019. Epub 2012 Dec 4. Review.


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