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Items: 1 to 20 of 67

  • Filters activated: Toxicology. Clear all to show 81 items.
1.

Relative potency of fifteen pyrrolizidine alkaloids to induce DNA damage as measured by micronucleus induction in HepaRG human liver cells.

Allemang A, Mahony C, Lester C, Pfuhler S.

Food Chem Toxicol. 2018 Nov;121:72-81. doi: 10.1016/j.fct.2018.08.003. Epub 2018 Aug 17.

PMID:
30125636
2.

New glutathione conjugate of pyrrolizidine alkaloids produced by human cytosolic enzyme-dependent reactions in vitro.

Muluneh F, Häkkinen MR, El-Dairi R, Pasanen M, Juvonen RO.

Rapid Commun Mass Spectrom. 2018 Aug 30;32(16):1344-1352. doi: 10.1002/rcm.8173.

PMID:
29788543
3.

PXR: Structure-specific activation by hepatotoxic pyrrolizidine alkaloids.

Luckert C, Braeuning A, Lampen A, Hessel-Pras S.

Chem Biol Interact. 2018 May 25;288:38-48. doi: 10.1016/j.cbi.2018.04.017. Epub 2018 Apr 14.

PMID:
29665350
4.

Use of physiologically based kinetic modelling-facilitated reverse dosimetry to convert in vitro cytotoxicity data to predicted in vivo liver toxicity of lasiocarpine and riddelliine in rat.

Chen L, Ning J, Louisse J, Wesseling S, Rietjens IMCM.

Food Chem Toxicol. 2018 Jun;116(Pt B):216-226. doi: 10.1016/j.fct.2018.04.012. Epub 2018 Apr 7.

5.

Development of an in vitro screening method of acute cytotoxicity of the pyrrolizidine alkaloid lasiocarpine in human and rodent hepatic cell lines by increasing susceptibility.

Forsch K, Schöning V, Disch L, Siewert B, Unger M, Drewe J.

J Ethnopharmacol. 2018 May 10;217:134-139. doi: 10.1016/j.jep.2018.02.018. Epub 2018 Feb 14.

PMID:
29454024
6.

Pyrrolizidine alkaloid-derived DNA adducts are common toxicological biomarkers of pyrrolizidine alkaloid N-oxides.

He X, Xia Q, Woodling K, Lin G, Fu PP.

J Food Drug Anal. 2017 Oct;25(4):984-991. doi: 10.1016/j.jfda.2017.09.001. Epub 2017 Sep 19.

7.

Development and validation of a QuEChERS method coupled to liquid chromatography and high resolution mass spectrometry to determine pyrrolizidine and tropane alkaloids in honey.

Martinello M, Borin A, Stella R, Bovo D, Biancotto G, Gallina A, Mutinelli F.

Food Chem. 2017 Nov 1;234:295-302. doi: 10.1016/j.foodchem.2017.04.186. Epub 2017 May 2.

PMID:
28551239
8.

Risk assessment for pyrrolizidine alkaloids detected in (herbal) teas and plant food supplements.

Chen L, Mulder PPJ, Louisse J, Peijnenburg A, Wesseling S, Rietjens IMCM.

Regul Toxicol Pharmacol. 2017 Jun;86:292-302. doi: 10.1016/j.yrtph.2017.03.019. Epub 2017 Mar 27. Review.

9.

A 28-day oral toxicity study of echimidine and lasiocarpine in Wistar rats.

Dalefield RR, Gosse MA, Mueller U.

Regul Toxicol Pharmacol. 2016 Nov;81:146-154. doi: 10.1016/j.yrtph.2016.08.006. Epub 2016 Aug 19.

PMID:
27546169
10.

Species-Specific Differences in the in Vitro Metabolism of Lasiocarpine.

Fashe MM, Juvonen RO, Petsalo A, Räsänen J, Pasanen M.

Chem Res Toxicol. 2015 Oct 19;28(10):2034-44. doi: 10.1021/acs.chemrestox.5b00253. Epub 2015 Oct 2.

PMID:
26395423
11.

An in vitro comparison of the cytotoxic potential of selected dehydropyrrolizidine alkaloids and some N-oxides.

Field RA, Stegelmeier BL, Colegate SM, Brown AW, Green BT.

Toxicon. 2015 Apr;97:36-45. doi: 10.1016/j.toxicon.2015.02.001. Epub 2015 Feb 7.

PMID:
25666399
12.

In silico prediction of the site of oxidation by cytochrome P450 3A4 that leads to the formation of the toxic metabolites of pyrrolizidine alkaloids.

Fashe MM, Juvonen RO, Petsalo A, Vepsäläinen J, Pasanen M, Rahnasto-Rilla M.

Chem Res Toxicol. 2015 Apr 20;28(4):702-10. doi: 10.1021/tx500478q. Epub 2015 Feb 17.

PMID:
25651456
13.

Heliotropium europaeum poisoning in cattle and analysis of its pyrrolizidine alkaloid profile.

Shimshoni JA, Mulder PP, Bouznach A, Edery N, Pasval I, Barel S, Abd-El Khaliq M, Perl S.

J Agric Food Chem. 2015 Feb 11;63(5):1664-72. doi: 10.1021/jf5052199. Epub 2015 Jan 27.

PMID:
25591008
14.

Identification of a new reactive metabolite of pyrrolizidine alkaloid retrorsine: (3H-pyrrolizin-7-yl)methanol.

Fashe MM, Juvonen RO, Petsalo A, Rahnasto-Rilla M, Auriola S, Soininen P, Vepsäläinen J, Pasanen M.

Chem Res Toxicol. 2014 Nov 17;27(11):1950-7. doi: 10.1021/tx5002964. Epub 2014 Oct 21.

PMID:
25295702
15.

Pyrrolizidine alkaloid-derived DNA adducts as a common biological biomarker of pyrrolizidine alkaloid-induced tumorigenicity.

Xia Q, Zhao Y, Von Tungeln LS, Doerge DR, Lin G, Cai L, Fu PP.

Chem Res Toxicol. 2013 Sep 16;26(9):1384-96. doi: 10.1021/tx400241c. Epub 2013 Aug 26.

PMID:
23937665
16.

Metabolism, genotoxicity, and carcinogenicity of comfrey.

Mei N, Guo L, Fu PP, Fuscoe JC, Luan Y, Chen T.

J Toxicol Environ Health B Crit Rev. 2010 Oct;13(7-8):509-26. doi: 10.1080/10937404.2010.509013.

17.

Determination of pyrrolizidine alkaloids in comfrey by liquid chromatography-electrospray ionization mass spectrometry.

Liu F, Wan SY, Jiang Z, Li SF, Ong ES, Osorio JC.

Talanta. 2009 Dec 15;80(2):916-23. doi: 10.1016/j.talanta.2009.08.020. Epub 2009 Aug 20.

PMID:
19836573
18.

Formation of DHP-derived DNA adducts from metabolic activation of the prototype heliotridine-type pyrrolizidine alkaloid, heliotrine.

Xia Q, Yan J, Chou MW, Fu PP.

Toxicol Lett. 2008 May 5;178(2):77-82. doi: 10.1016/j.toxlet.2008.02.008. Epub 2008 Mar 4.

PMID:
18395999
19.
20.

Evaporative light scattering detection of pyrrolizidine alkaloids.

Schaneberg BT, Molyneux RJ, Khan IA.

Phytochem Anal. 2004 Jan-Feb;15(1):36-9.

PMID:
14979525

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