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DNA topoisomerases and their poisoning by anticancer and antibacterial drugs.

Pommier Y, Leo E, Zhang H, Marchand C.

Chem Biol. 2010 May 28;17(5):421-33. doi: 10.1016/j.chembiol.2010.04.012. Review.


Bone marrow and tumor cell colony-forming units and human tumor xenograft efficacy of noncamptothecin and camptothecin topoisomerase I inhibitors.

Kurtzberg LS, Battle T, Rouleau C, Bagley RG, Agata N, Yao M, Schmid S, Roth S, Crawford J, Krumbholz R, Ewesuedo R, Yu XJ, Wang F, Lavoie EJ, Teicher BA.

Mol Cancer Ther. 2008 Oct;7(10):3212-22. doi: 10.1158/1535-7163.MCT-08-0568.


Facile formation of hydrophilic derivatives of 5H-8,9-dimethoxy-5-[2-(N,N-dimethylamino)ethyl]-2,3-methylenedioxydibenzo[c,h] [1,6]naphthyridin-6-one (ARC-111) and its 12-aza analog via quaternary ammonium intermediates.

Feng W, Satyanarayana M, Tsai YC, Liu AA, Liu LF, Lavoie EJ.

Bioorg Med Chem Lett. 2008 Jun 15;18(12):3570-2. doi: 10.1016/j.bmcl.2008.05.005. Epub 2008 May 6.


6-Substituted 6H-dibenzo[c,h][2,6]naphthyridin-5-ones: reversed lactam analogues of ARC-111 with potent topoisomerase I-targeting activity and cytotoxicity.

Zhu S, Ruchelman AL, Zhou N, Liu A, Liu LF, LaVoie EJ.

Bioorg Med Chem. 2006 May 1;14(9):3131-43. Epub 2006 Jan 18.


Esters and amides of 2,3-dimethoxy-8,9-methylenedioxy-benzo[i]phenanthridine-12-carboxylic acid: potent cytotoxic and topoisomerase I-targeting agents.

Zhu S, Ruchelman AL, Zhou N, Liu AA, Liu LF, LaVoie EJ.

Bioorg Med Chem. 2005 Dec 15;13(24):6782-94. Epub 2005 Sep 8.


Characterization of ARC-111 as a novel topoisomerase I-targeting anticancer drug.

Li TK, Houghton PJ, Desai SD, Daroui P, Liu AA, Hars ES, Ruchelman AL, LaVoie EJ, Liu LF.

Cancer Res. 2003 Dec 1;63(23):8400-7.

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