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J Struct Funct Genomics. 2014 Dec;15(4):209-14. doi: 10.1007/s10969-014-9185-y. Epub 2014 Jul 3.

Solution NMR structures of immunoglobulin-like domains 7 and 12 from obscurin-like protein 1 contribute to the structural coverage of the Human Cancer Protein Interaction Network.

Author information

1
Department of Chemistry, The State University of New York at Buffalo and Northeast Structural Genomics Consortium, Buffalo, NY, 14260, USA.

Abstract

High-quality solution NMR structures of immunoglobulin-like domains 7 and 12 from human obscurin-like protein 1 were solved. The two domains share 30% sequence identity and their structures are, as expected, rather similar. The new structures contribute to structural coverage of human cancer associated proteins. Mutations of Arg 812 in domain 7 cause the rare 3-M syndrome, and this site is located in a surface area predicted to be involved in protein-protein interactions.

PMID:
24989974
PMCID:
PMC4945113
DOI:
10.1007/s10969-014-9185-y
[Indexed for MEDLINE]
Free PMC Article

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