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Nucleic Acids Res. 2012 Jul;40(Web Server issue):W542-6. doi: 10.1093/nar/gks373. Epub 2012 May 8.

RPF: a quality assessment tool for protein NMR structures.

Author information

1
Center for Advanced Biotechnology and Medicine, Northeast Structural Genomic Consortium, Rutgers University, 679 Hoes Lane, Piscataway, NJ 08854, USA.

Abstract

We describe the RPF web server, a quality assessment tool for protein NMR structures. The RPF server measures the 'goodness-of-fit' of the 3D structure with NMR chemical shift and unassigned NOESY data, and calculates a discrimination power (DP) score, which estimates the differences between the fits of the query structures and random coil structures to these experimental data. The DP-score is an accuracy predictor of the query structure. The RPF server also maps local structure quality measures onto the 3D structure using an online molecular viewer, and onto the NMR spectra, allowing refinement of the structure and/or NOESY peak list data. The RPF server is available at: http://nmr.cabm.rutgers.edu/rpf.

PMID:
22570414
PMCID:
PMC3394279
DOI:
10.1093/nar/gks373
[Indexed for MEDLINE]
Free PMC Article

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