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Biochim Biophys Acta. 2012 Nov;1824(11):1223-30. doi: 10.1016/j.bbapap.2011.11.007. Epub 2011 Dec 7.

The methylthiolation reaction mediated by the Radical-SAM enzymes.

Author information

1
Institut de Recherches en Technologie et Sciences pour le Vivant IRTSV-LCBM, UMR 5249 CEA/CNRS/UJF, CEA-Grenoble, 17 avenue des Martyrs, 38054, Grenoble Cedex 09, France. mohamed.atta@cea.fr

Abstract

Over the past 10 years, considerable progress has been made in our understanding of the mechanistic enzymology of the Radical-SAM enzymes. It is now clear that these enzymes appear to be involved in a remarkably wide range of chemically challenging reactions. This review article highlights mechanistic and structural aspects of the methylthiotransferases (MTTases) sub-class of the Radical-SAM enzymes. The mechanism of methylthio insertion, now observed to be performed by three different enzymes is an exciting unsolved problem. This article is part of a Special Issue entitled: Radical SAM enzymes and Radical Enzymology.

PMID:
22178611
PMCID:
PMC4150254
DOI:
10.1016/j.bbapap.2011.11.007
[Indexed for MEDLINE]
Free PMC Article

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