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Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Oct 1;66(Pt 10):1306-8. doi: 10.1107/S1744309110035748. Epub 2010 Sep 30.

Ligands in crystal structures that aid in functional characterization.

Author information

1
The Department of Chemical Physiology and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California, USA. aespeers@scripps.edu

Abstract

Liganded structures can be instrumental in assigning function to uncharacterized proteins by revealing active sites, conserved residues, binding motifs, and substrate specificity. This introduction provides an overview and commentary on the value of liganded structures emerging from the JCSG structural genomics initiative.

PMID:
20944226
PMCID:
PMC2954220
DOI:
10.1107/S1744309110035748
[Indexed for MEDLINE]
Free PMC Article

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