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Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Oct 1;66(Pt 10):1226-9. doi: 10.1107/S1744309110013242. Epub 2010 Jul 6.

New variants of known folds: do they bring new biology?

Author information

1
National Center for Biotechnology Information, National Institutes of Health, Bethesda, Maryland 20894, USA. koonin@ncbi.nlm.nih.gov

Abstract

New distinct versions of known protein folds provide a powerful means of protein-function prediction that complements sequence and genomic context analysis. These structures do not supplant direct biochemical experiments, but are indispensable for the complete characterization of proteins.

PMID:
20944215
PMCID:
PMC2954209
DOI:
10.1107/S1744309110013242
[Indexed for MEDLINE]
Free PMC Article

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