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Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Oct 1;66(Pt 10):1190-7. doi: 10.1107/S1744309110007177. Epub 2010 Jul 6.

Structural classification of proteins and structural genomics: new insights into protein folding and evolution.

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1
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, England.

Abstract

During the past decade, the Protein Structure Initiative (PSI) centres have become major contributors of new families, superfamilies and folds to the Structural Classification of Proteins (SCOP) database. The PSI results have increased the diversity of protein structural space and accelerated our understanding of it. This review article surveys a selection of protein structures determined by the Joint Center for Structural Genomics (JCSG). It presents previously undescribed β-sheet architectures such as the double barrel and spiral β-roll and discusses new examples of unusual topologies and peculiar structural features observed in proteins characterized by the JCSG and other Structural Genomics centres.

PMID:
20944210
PMCID:
PMC2954204
DOI:
10.1107/S1744309110007177
[Indexed for MEDLINE]
Free PMC Article

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