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Methods Mol Biol. 2009;569:157-72. doi: 10.1007/978-1-59745-524-4_8.

Applications of bioinformatics to protein structures: how protein structure and bioinformatics overlap.

Author information

1
Burnham Institute for Medical Research, La Jolla, CA, USA.

Abstract

In this chapter, we will focus on the role of bioinformatics to analyze a protein after its protein structure has been determined. First, we present how to validate protein structures for quality assurance. Then, we discuss how to analyze protein-protein interfaces and how to predict the biomolecule which is the biological oligomeric state of the protein. Finally, we discuss how to search for homologs based on the 3-D structure which is an essential step for understanding protein function.

PMID:
19623490
DOI:
10.1007/978-1-59745-524-4_8
[Indexed for MEDLINE]

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