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Science. 2006 Jul 21;313(5785):354-7.

Crystal structure of a divalent metal ion transporter CorA at 2.9 angstrom resolution.

Author information

1
Division of Biophysics, Department of Medical Biochemistry and Biophysics, Karolinska Institute, SE-171 77 Stockholm, Sweden. Said.Eshaghi@ki.se

Erratum in

  • Science. 2006 Sep 8;313(5792):1389.

Abstract

CorA family members are ubiquitously distributed transporters of divalent metal cations and are considered to be the primary Mg2+ transporter of Bacteria and Archaea. We have determined a 2.9 angstrom resolution structure of CorA from Thermotoga maritima that reveals a pentameric cone-shaped protein. Two potential regulatory metal binding sites are found in the N-terminal domain that bind both Mg2+ and Co2+. The structure of CorA supports an efflux system involving dehydration and rehydration of divalent metal ions potentially mediated by a ring of conserved aspartate residues at the cytoplasmic entrance and a carbonyl funnel at the periplasmic side of the pore.

PMID:
16857941
DOI:
10.1126/science.1127121
[Indexed for MEDLINE]
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