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Chem Commun (Camb). 2006 Apr 28;(16):1781-3. Epub 2006 Mar 17.

A lag-phase in the reduction of flavin dependent thymidylate synthase (FDTS) revealed a mechanistic missing link.

Author information

1
Department of Chemistry, University of Iowa, Iowa City, IA, USA. amnon-kohen@uiowa.edu

Abstract

An unexpected substrate-dependent lag-phase, found in the single turnover reduction of FDTS bound flavin, sheds light on the molecular mechanism of this alternative thymidylate synthase.

PMID:
16609803
DOI:
10.1039/b517881a
[Indexed for MEDLINE]

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