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Trends Biochem Sci. 2004 Mar;29(3):106-10.

NERD: a DNA processing-related domain present in the anthrax virulence plasmid, pXO1.

Author information

1
Program in Bioinformatics and Systems Biology, The Burnham Institute, 10901 N. Torrey Pines Road, La Jolla, CA 92037, USA.

Abstract

We have identified a new domain in a broad range of bacterial, as well as single archaeal and plant proteins. Its presence in the virulence-related pXO1 plasmid of Bacillus anthracis as well as in several other pathogens makes it a possible drug target. We term the new domain nuclease-related domain (NERD) because of its distant similarity to endonucleases.

PMID:
15055202
DOI:
10.1016/j.tibs.2004.01.002
[Indexed for MEDLINE]

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