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J Struct Biol. 2003 Apr;142(1):207-17.

A fully integrated protein crystallization platform for small-molecule drug discovery.

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1
Syrrx, Inc., 10410 Science Center Drive, San Diego, CA 92121, USA.

Abstract

Structure-based drug discovery in the pharmaceutical industry benefits from cost-efficient methodologies that quickly assess the feasibility of specific, often refractory, protein targets to form well-diffracting crystals. By tightly coupling construct and purification diversity with nanovolume crystallization, the Structural Biology Group at Syrrx has developed such a platform to support its small-molecule drug-discovery program. During the past 18 months of operation at Syrrx, the Structural Biology Group has executed several million crystallization and imaging trials on over 400 unique drug-discovery targets. Here, key components of the platform, as well as an analysis of some experimental results that allowed for platform optimization, will be described.

PMID:
12718932
[Indexed for MEDLINE]

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