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Items: 1 to 20 of 135

1.

Bezafibrate In Vivo Administration Prevents 3-Methylglutaric Acid-Induced Impairment of Redox Status, Mitochondrial Biogenesis, and Neural Injury in Brain of Developing Rats.

da Rosa-Junior NT, Parmeggiani B, da Rosa MS, Glänzel NM, de Moura Alvorcem L, Wajner M, Leipnitz G.

Neurotox Res. 2019 May;35(4):809-822. doi: 10.1007/s12640-019-00019-9. Epub 2019 Mar 9.

PMID:
30850947
2.

New C-2 diastereomers of flavanone glycosides conjugated with 3-hydroxy-3-methylglutaric acid from the pericarp of Citrus grandis (L.) Osbeck.

Ma SG, Wang RB, Li WR, Liu YB, Qu J, Li Y, Wang XJ, Xu S, Yu SS.

Bioorg Chem. 2018 Oct;80:519-524. doi: 10.1016/j.bioorg.2018.06.024. Epub 2018 Jun 27.

PMID:
30005202
3.

CALB-Catalyzed Two-Step Alcoholytic Desymmetrization of 3-Methylglutaric Diazolides in MTBE.

Wu TY, Lai YR, Tsai SW.

Appl Biochem Biotechnol. 2018 Jul;185(3):578-592. doi: 10.1007/s12010-017-2675-1. Epub 2017 Dec 15. Erratum in: Appl Biochem Biotechnol. 2018 Jan 10;:.

PMID:
29243042
4.

Selective screening of glutaric acid acidurias by capillary electrophoresis-mass spectrometry.

Fernández-Bravo J, de Andrés F, Zougagh M, Ríos Á.

J Pharm Biomed Anal. 2017 Oct 25;145:40-45. doi: 10.1016/j.jpba.2017.06.037. Epub 2017 Jun 19.

PMID:
28648786
5.

Coupled brain and urine spectroscopy - in vivo metabolomic characterization of HMG-CoA lyase deficiency in 5 patients.

Roland D, Jissendi-Tchofo P, Briand G, Vamecq J, Fontaine M, Ultré V, Acquaviva-Bourdain C, Mention K, Dobbelaere D.

Mol Genet Metab. 2017 Jun;121(2):111-118. doi: 10.1016/j.ymgme.2017.03.006. Epub 2017 Mar 30.

PMID:
28396157
6.

3-Hydroxy-3-methylglutaric and 3-methylglutaric acids impair redox status and energy production and transfer in rat heart: relevance for the pathophysiology of cardiac dysfunction in 3-hydroxy-3-methylglutaryl-coenzyme A lyase deficiency.

da Rosa MS, Seminotti B, Ribeiro CA, Parmeggiani B, Grings M, Wajner M, Leipnitz G.

Free Radic Res. 2016 Sep;50(9):997-1010. doi: 10.1080/10715762.2016.1214952. Epub 2016 Aug 23.

PMID:
27430492
7.

Experimental Evidence that 3-Methylglutaric Acid Disturbs Mitochondrial Function and Induced Oxidative Stress in Rat Brain Synaptosomes: New Converging Mechanisms.

Colín-González AL, Paz-Loyola AL, de Lima ME, Galván-Arzate S, Seminotti B, Ribeiro CA, Leipnitz G, Souza DO, Wajner M, Santamaría A.

Neurochem Res. 2016 Oct;41(10):2619-2626. Epub 2016 Jun 9.

PMID:
27278758
8.

Prenylfuranocoumarin-HMGA-flavonol glucoside conjugates and other constituents of the fruit peels of Citrus hystrix and their anticholinesterase activity.

Seeka C, Sutthivaiyakit P, Youkwan J, Hertkorn N, Harir M, Schmitt-Kopplin P, Sutthivaiyakit S.

Phytochemistry. 2016 Jul;127:38-49. doi: 10.1016/j.phytochem.2016.03.009. Epub 2016 Mar 16.

PMID:
26995149
9.

Induction of a Proinflammatory Response in Cortical Astrocytes by the Major Metabolites Accumulating in HMG-CoA Lyase Deficiency: the Role of ERK Signaling Pathway in Cytokine Release.

Fernandes CG, Rodrigues MDN, Seminotti B, Colín-González AL, Santamaria A, Quincozes-Santos A, Wajner M.

Mol Neurobiol. 2016 Aug;53(6):3586-3595. doi: 10.1007/s12035-015-9289-9. Epub 2015 Jun 23.

PMID:
26099308
10.

Evidence that 3-hydroxy-3-methylglutaric and 3-methylglutaric acids induce DNA damage in rat striatum.

da Rosa MS, Scaini G, Damiani AP, Longaretti LM, Pereira M, Seminotti B, Zapelini HG, Schuck PF, Streck EL, de Andrade VM, Wajner M, Leipnitz G.

Metab Brain Dis. 2015 Aug;30(4):1055-62. doi: 10.1007/s11011-015-9675-z. Epub 2015 May 5.

PMID:
25939283
11.

The neuropsychological profile of patients with 3-methylglutaconic aciduria type III, Costeff syndrome.

Sofer S, Schweiger A, Blumkin L, Yahalom G, Anikster Y, Lev D, Ben-Zeev B, Lerman-Sagie T, Hassin-Baer S.

Am J Med Genet B Neuropsychiatr Genet. 2015 Apr;168B(3):197-203. doi: 10.1002/ajmg.b.32296. Epub 2015 Feb 5.

PMID:
25657044
12.

Increased oxidative stress in patients with 3-hydroxy-3-methylglutaric aciduria.

Dos Santos Mello M, Ribas GS, Wayhs CA, Hammerschmidt T, Guerreiro GB, Favenzani JL, Sitta Â, de Moura Coelho D, Wajner M, Vargas CR.

Mol Cell Biochem. 2015 Apr;402(1-2):149-55. doi: 10.1007/s11010-014-2322-x. Epub 2015 Jan 4.

PMID:
25557019
13.

A neonatal case of 3-hydroxy-3-methylglutaric-coenzyme A lyase deficiency.

Santarelli F, Cassanello M, Enea A, Poma F, D'Onofrio V, Guala G, Garrone G, Puccinelli P, Caruso U, Porta F, Spada M.

Ital J Pediatr. 2013 May 24;39:33. doi: 10.1186/1824-7288-39-33.

14.

In vivo experimental evidence that the major metabolites accumulating in 3-hydroxy-3-methylglutaryl-CoA lyase deficiency induce oxidative stress in striatum of developing rats: a potential pathophysiological mechanism of striatal damage in this disorder.

Fernandes CG, da Rosa MS, Seminotti B, Pierozan P, Martell RW, Lagranha VL, Busanello EN, Leipnitz G, Wajner M.

Mol Genet Metab. 2013 Jun;109(2):144-53. doi: 10.1016/j.ymgme.2013.03.017. Epub 2013 Apr 6.

PMID:
23611578
15.

Dehydropyrrolizidine alkaloids in two Cryptantha species: including two new open chain diesters one of which is amphoteric.

Colegate SM, Gardner DR, Davis TZ, Betz JM, Panter KE.

Phytochem Anal. 2013 May-Jun;24(3):201-12. doi: 10.1002/pca.2400. Epub 2012 Oct 15.

PMID:
23070903
16.

Multiple effects of gymnopilin on circulatory system of the rat.

Nishio A, Kitamura N, Tanaka S, Miyazaki S, Ichiyanagi T, Shimomura N, Shibuya I, Aimi T.

Biol Pharm Bull. 2012;35(8):1300-5.

17.

Flavonol glycosides acylated with 3-hydroxy-3-methylglutaric acid as systematic characters in Rosa.

Porter EA, van den Bos AA, Kite GC, Veitch NC, Simmonds MS.

Phytochemistry. 2012 Sep;81:90-6. doi: 10.1016/j.phytochem.2012.05.006. Epub 2012 Jun 20.

PMID:
22721781
18.

Gymnopilin--a substance produced by the hallucinogenic mushroom, Gymnopilus junonius--mobilizes intracellular Ca(2+) in dorsal root ganglion cells.

Miyazaki S, Kitamura N, Nishio A, Tanaka S, Kayano T, Moriya T, Ichiyanagi T, Shimomura N, Shibuya I, Aimi T.

Biomed Res. 2012 Apr;33(2):111-8.

19.

Neurochemical evidence that 3-methylglutaric acid inhibits synaptic Na+,K+-ATPase activity probably through oxidative damage in brain cortex of young rats.

Ribeiro CA, Hickmann FH, Wajner M.

Int J Dev Neurosci. 2011 Feb;29(1):1-7. doi: 10.1016/j.ijdevneu.2010.10.007. Epub 2010 Nov 2.

20.

Differential HMG-CoA lyase expression in human tissues provides clues about 3-hydroxy-3-methylglutaric aciduria.

Puisac B, Arnedo M, Casale CH, Ribate MP, Castiella T, Ramos FJ, Ribes A, Pérez-Cerdá C, Casals N, Hegardt FG, Pié J.

J Inherit Metab Dis. 2010 Aug;33(4):405-10. doi: 10.1007/s10545-010-9097-3. Epub 2010 Jun 8.

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