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Items: 1 to 20 of 130

  • Filters activated: Toxicology. Clear all to show 382 items.
1.

Design, synthesis, in silico ADMET profile and GABA-A docking of novel phthalazines as potent anticonvulsants.

El-Helby AA, Ayyad RRA, Zayed MF, Abulkhair HS, Elkady H, El-Adl K.

Arch Pharm (Weinheim). 2019 May;352(5):e1800387. doi: 10.1002/ardp.201800387. Epub 2019 Apr 15.

PMID:
30989729
2.

Design and synthesis of novel PARP-1 inhibitors based on pyridopyridazinone scaffold.

Elmasry GF, Aly EE, Awadallah FM, El-Moghazy SM.

Bioorg Chem. 2019 Mar 28;87:655-666. doi: 10.1016/j.bioorg.2019.03.068. [Epub ahead of print]

PMID:
30952061
3.

Synthesis, molecular modelling and anticancer evaluation of new pyrrolo[1,2-b]pyridazine and pyrrolo[2,1-a]phthalazine derivatives.

Popovici L, Amarandi RM, Mangalagiu II, Mangalagiu V, Danac R.

J Enzyme Inhib Med Chem. 2019 Dec;34(1):230-243. doi: 10.1080/14756366.2018.1550085.

4.

Synthesis, preliminarily biological evaluation and molecular docking study of new Olaparib analogues as multifunctional PARP-1 and cholinesterase inhibitors.

Gao CZ, Dong W, Cui ZW, Yuan Q, Hu XM, Wu QM, Han X, Xu Y, Min ZL.

J Enzyme Inhib Med Chem. 2019 Dec;34(1):150-162. doi: 10.1080/14756366.2018.1530224.

5.

2,3-Dihydrofurans as Potential Cytotoxic and Antibacterial Agents: Tandem Knoevenagel-Michael Cyclization for the Synthesis of 2,3-Dihydrofurans by Using α-Tosyloxy Ketone Precursors.

Kashanna J, Kumar RA, Kishore R, Kumar DN, Kumar AS.

Chem Biodivers. 2018 Nov;15(11):e1800277. doi: 10.1002/cbdv.201800277. Epub 2018 Oct 26.

PMID:
30187628
6.

Phthalazine-1,4-dione derivatives as non-competitive AMPA receptor antagonists: design, synthesis, anticonvulsant evaluation, ADMET profile and molecular docking.

El-Helby AA, Ayyad RRA, El-Adl K, Elkady H.

Mol Divers. 2018 Aug 30. doi: 10.1007/s11030-018-9871-y. [Epub ahead of print]

PMID:
30168051
7.

Inhibitory effects of drugs on the metabolic activity of mouse and human aldehyde oxidases and influence on drug-drug interactions.

Takaoka N, Sanoh S, Okuda K, Kotake Y, Sugahara G, Yanagi A, Ishida Y, Tateno C, Tayama Y, Sugihara K, Kitamura S, Kurosaki M, Terao M, Garattini E, Ohta S.

Biochem Pharmacol. 2018 Aug;154:28-38. doi: 10.1016/j.bcp.2018.04.017. Epub 2018 Apr 17.

PMID:
29678521
8.

Design, Synthesis, Characterization, QSAR, Docking, Anti-inflammatory and Analgesic Evaluation of Some New Phthalazinediones.

Sherif YE, Alansari R, Gouda MA.

Antiinflamm Antiallergy Agents Med Chem. 2018;17(1):3-15. doi: 10.2174/1871523017666180413111321.

PMID:
29651968
9.

Identification of enzymes responsible for dantrolene metabolism in the human liver: A clue to uncover the cause of liver injury.

Amano T, Fukami T, Ogiso T, Hirose D, Jones JP, Taniguchi T, Nakajima M.

Biochem Pharmacol. 2018 May;151:69-78. doi: 10.1016/j.bcp.2018.03.002. Epub 2018 Mar 6.

PMID:
29522712
10.

Design, Synthesis, Molecular Docking, and Anticancer Activity of Phthalazine Derivatives as VEGFR-2 Inhibitors.

El-Helby AA, Ayyad RRA, Sakr H, El-Adl K, Ali MM, Khedr F.

Arch Pharm (Weinheim). 2017 Dec;350(12). doi: 10.1002/ardp.201700240. Epub 2017 Nov 13.

PMID:
29131379
11.

New racemic annulated pyrazolo[1,2-b]phthalazines as tacrine-like AChE inhibitors with potential use in Alzheimer's disease.

Jalili-Baleh L, Nadri H, Moradi A, Bukhari SNA, Shakibaie M, Jafari M, Golshani M, Homayouni Moghadam F, Firoozpour L, Asadipour A, Emami S, Khoobi M, Foroumadi A.

Eur J Med Chem. 2017 Oct 20;139:280-289. doi: 10.1016/j.ejmech.2017.07.072. Epub 2017 Jul 31.

PMID:
28803044
12.

Design, synthesis, and biological evaluation of optimized phthalazine derivatives as hedgehog signaling pathway inhibitors.

Lu X, Peng Y, Wang C, Yang J, Bao X, Dong Q, Zhao W, Tan W, Dong X.

Eur J Med Chem. 2017 Sep 29;138:384-395. doi: 10.1016/j.ejmech.2017.06.031. Epub 2017 Jun 21.

PMID:
28688278
13.

Molecular Cloning and Characterization of Marmoset Aldehyde Oxidase.

Uehara S, Uno Y, Okamoto E, Inoue T, Sasaki E, Yamazaki H.

Drug Metab Dispos. 2017 Aug;45(8):883-886. doi: 10.1124/dmd.117.076042. Epub 2017 May 9.

PMID:
28487309
14.

Chemical characterisation of aerosols emitted by electronic cigarettes using thermal desorption-gas chromatography-time of flight mass spectrometry.

Rawlinson C, Martin S, Frosina J, Wright C.

J Chromatogr A. 2017 May 12;1497:144-154. doi: 10.1016/j.chroma.2017.02.050. Epub 2017 Apr 3.

15.

Aryl- or heteroaryl-based hydrazinylphthalazine derivatives as new potential antitrypanosomal agents.

Romero AH, Rodríguez J, García-Marchan Y, Leañez J, Serrano-Martín X, López SE.

Bioorg Chem. 2017 Jun;72:51-56. doi: 10.1016/j.bioorg.2017.03.008. Epub 2017 Mar 21.

PMID:
28359970
16.

Synthesis and in vitro anti-proliferative activity of some novel isatins conjugated with quinazoline/phthalazine hydrazines against triple-negative breast cancer MDA-MB-231 cells as apoptosis-inducing agents.

Eldehna WM, Almahli H, Al-Ansary GH, Ghabbour HA, Aly MH, Ismael OE, Al-Dhfyan A, Abdel-Aziz HA.

J Enzyme Inhib Med Chem. 2017 Dec;32(1):600-613. doi: 10.1080/14756366.2017.1279155.

17.

Design, synthesis, structure-activity relationship and mechanism of action studies of a series of 4-chloro-1-phthalazinyl hydrazones as a potent agent against Leishmania braziliensis.

Romero AH, Medina R, Alcala A, García-Marchan Y, Núñez-Duran J, Leañez J, Mijoba A, Ciangherotti C, Serrano-Martín X, López SE.

Eur J Med Chem. 2017 Feb 15;127:606-620. doi: 10.1016/j.ejmech.2017.01.022. Epub 2017 Jan 17.

PMID:
28119201
18.

Anticancer activity assessment of two novel binuclear platinum (II) complexes.

Shahsavani MB, Ahmadi S, Aseman MD, Nabavizadeh SM, Rashidi M, Asadi Z, Erfani N, Ghasemi A, Saboury AA, Niazi A, Bahaoddini A, Yousefi R.

J Photochem Photobiol B. 2016 Aug;161:345-54. doi: 10.1016/j.jphotobiol.2016.05.025. Epub 2016 Jun 2.

PMID:
27289447
19.
20.

Increasing the binding affinity of VEGFR-2 inhibitors by extending their hydrophobic interaction with the active site: Design, synthesis and biological evaluation of 1-substituted-4-(4-methoxybenzyl)phthalazine derivatives.

Eldehna WM, Abou-Seri SM, El Kerdawy AM, Ayyad RR, Hamdy AM, Ghabbour HA, Ali MM, Abou El Ella DA.

Eur J Med Chem. 2016 May 4;113:50-62. doi: 10.1016/j.ejmech.2016.02.029. Epub 2016 Feb 15.

PMID:
26922228

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