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IEEE Trans Med Imaging. 2007 Apr;26(4):487-96.

Topology-preserving tissue classification of magnetic resonance brain images.

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Johns Hopkins University Radiology and Radiological Science Neuroradiology Division, Baltimore, MD 21287, USA.


This paper presents a new framework for multiple object segmentation in medical images that respects the topological properties and relationships of structures as given by a template. The technique, known as topology-preserving, anatomy-driven segmentation (TOADS), combines advantages of statistical tissue classification, topology-preserving fast marching methods, and image registration to enforce object-level relationships with little constraint over the geometry. When applied to the problem of brain segmentation, it directly provides a cortical surface with spherical topology while segmenting the main cerebral structures. Validation on simulated and real images characterises the performance of the algorithm with regard to noise, inhomogeneities, and anatomical variations.

[Indexed for MEDLINE]

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