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Transgenic knockout mice exclusively expressing human hemoglobin S after transfer of a 240-kb betas-globin yeast artificial chromosome: A mouse model of sickle cell anemia.

Chang JC, Lu R, Lin C, Xu SM, Kan YW, Porcu S, Carlson E, Kitamura M, Yang S, Flebbe-Rehwaldt L, Gaensler KM.

Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):14886-90.


Transgenic knockout mice with exclusively human sickle hemoglobin and sickle cell disease.

Pászty C, Brion CM, Manci E, Witkowska HE, Stevens ME, Mohandas N, Rubin EM.

Science. 1997 Oct 31;278(5339):876-8.


A second generation transgenic mouse model expressing both hemoglobin S (HbS) and HbS-Antilles results in increased phenotypic severity.

Fabry ME, Sengupta A, Suzuka SM, Costantini F, Rubin EM, Hofrichter J, Christoph G, Manci E, Culberson D, Factor SM, Nagel RL.

Blood. 1995 Sep 15;86(6):2419-28.


Knockout-transgenic mouse model of sickle cell disease.

Ryan TM, Ciavatta DJ, Townes TM.

Science. 1997 Oct 31;278(5339):873-6.


A recombinant human hemoglobin with anti-sickling properties greater than fetal hemoglobin.

Levasseur DN, Ryan TM, Reilly MP, McCune SL, Asakura T, Townes TM.

J Biol Chem. 2004 Jun 25;279(26):27518-24. Epub 2004 Apr 14.


Correction of the sickle cell mutation in embryonic stem cells.

Chang JC, Ye L, Kan YW.

Proc Natl Acad Sci U S A. 2006 Jan 24;103(4):1036-40. Epub 2006 Jan 11.


Mouse models of sickle cell disease.

Beuzard Y.

Transfus Clin Biol. 2008 Feb-Mar;15(1-2):7-11. doi: 10.1016/j.tracli.2008.04.001. Epub 2008 May 27.


A transgenic mouse model of sickle cell disorder.

Greaves DR, Fraser P, Vidal MA, Hedges MJ, Ropers D, Luzzatto L, Grosveld F.

Nature. 1990 Jan 11;343(6254):183-5.


High oxygen environment during pregnancy rescues sickle cell anemia mice from prenatal death.

Ye L, Chang JC, Lu R, Kan YW.

Blood Cells Mol Dis. 2008 Jul-Aug;41(1):67-72. doi: 10.1016/j.bcmd.2007.12.002. Epub 2008 Jan 22.


Transgene copy number-dependent rescue of murine beta-globin knockout mice carrying a 183 kb human beta-globin BAC genomic fragment.

Vadolas J, Wardan H, Bosmans M, Zaibak F, Jamsai D, Voullaire L, Williamson R, Ioannou PA.

Biochim Biophys Acta. 2005 May 1;1728(3):150-62. Epub 2005 Mar 17.


Transgenic analysis of a 100-kb human beta-globin cluster-containing DNA fragment propagated as a bacterial artificial chromosome.

Kaufman RM, Pham CT, Ley TJ.

Blood. 1999 Nov 1;94(9):3178-84. Erratum in: Blood 2000 Feb 1;95(3):744.


Pathophysiology of a sickle cell trait mouse model: human alpha(beta)(S) transgenes with one mouse beta-globin allele.

Noguchi CT, Gladwin M, Diwan B, Merciris P, Smith R, Yu X, Buzard G, Fitzhugh A, Keefer LK, Schechter AN, Mohandas N.

Blood Cells Mol Dis. 2001 Nov-Dec;27(6):971-7.


Sequences in the (A)gamma-delta intergenic region are not required for stage-specific regulation of the human beta-globin gene locus.

Gaensler KM, Zhang Z, Lin C, Yang S, Hardt K, Flebbe-Rehwaldt L.

Proc Natl Acad Sci U S A. 2003 Mar 18;100(6):3374-9. Epub 2003 Mar 10.


Magnetic resonance evidence of hypoxia in a homozygous alpha-knockout of a transgenic mouse model for sickle cell disease.

Fabry ME, Kennan RP, Paszty C, Costantini F, Rubin EM, Gore JC, Nagel RL.

J Clin Invest. 1996 Dec 1;98(11):2450-5.


The human beta globin locus introduced by YAC transfer exhibits a specific and reproducible pattern of developmental regulation in transgenic mice.

Porcu S, Kitamura M, Witkowska E, Zhang Z, Mutero A, Lin C, Chang J, Gaensler KM.

Blood. 1997 Dec 1;90(11):4602-9.


Towards a transgenic mouse model of sickle cell disease: hemoglobin SAD.

Trudel M, Saadane N, Garel MC, Bardakdjian-Michau J, Blouquit Y, Guerquin-Kern JL, Rouyer-Fessard P, Vidaud D, Pachnis A, Roméo PH, et al.

EMBO J. 1991 Nov;10(11):3157-65.

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