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Identification of naturally processed hepatitis C virus-derived major histocompatibility complex class I ligands.

Wölk B, Trautwein C, Büchele B, Kersting N, Blum HE, Rammensee HG, Cerny A, Stevanovic S, Moradpour D, Brass V.

PLoS One. 2012;7(1):e29286. doi: 10.1371/journal.pone.0029286. Epub 2012 Jan 3.


Use of recombinant protein to identify a motif-negative human cytotoxic T-cell epitope presented by HLA-A2 in the hepatitis C virus NS3 region.

Kurokohchi K, Akatsuka T, Pendleton CD, Takamizawa A, Nishioka M, Battegay M, Feinstone SM, Berzofsky JA.

J Virol. 1996 Jan;70(1):232-40.


Genetic immunization and comprehensive screening approaches in HLA-A2 transgenic mice lead to the identification of three novel epitopes in hepatitis C virus NS3 antigen.

Martin P, Parroche P, Chatel L, Barretto C, Beck A, Trépo C, Bain C, Lone YC, Inchauspé G, Fournillier A.

J Med Virol. 2004 Nov;74(3):397-405.


Relation between viral fitness and immune escape within the hepatitis C virus protease.

Söderholm J, Ahlén G, Kaul A, Frelin L, Alheim M, Barnfield C, Liljeström P, Weiland O, Milich DR, Bartenschlager R, Sällberg M.

Gut. 2006 Feb;55(2):266-74. Epub 2005 Aug 16.


CTL responses of HLA-A2.1-transgenic mice specific for hepatitis C viral peptides predict epitopes for CTL of humans carrying HLA-A2.1.

Shirai M, Arichi T, Nishioka M, Nomura T, Ikeda K, Kawanishi K, Engelhard VH, Feinstone SM, Berzofsky JA.

J Immunol. 1995 Mar 15;154(6):2733-42.


Genetic variability of hepatitis C virus non-structural protein 3 and virus-specific CD8+ response in patients with chronic hepatitis C.

López-Labrador FX, He XS, Berenguer M, Cheung RC, González-Candelas F, Wright TL, Greenberg HB.

J Med Virol. 2004 Apr;72(4):575-85.


An epitope in hepatitis C virus core region recognized by cytotoxic T cells in mice and humans.

Shirai M, Okada H, Nishioka M, Akatsuka T, Wychowski C, Houghten R, Pendleton CD, Feinstone SM, Berzofsky JA.

J Virol. 1994 May;68(5):3334-42.


[A HLA-A2-restricted-CTL epitope variation at the N-terminal of HCV helicase and the immune response of CTLs].

Guo HZ, Wang WL, Wang T.

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2004 May;20(3):325-7. Chinese.


Stable human lymphoblastoid cell lines constitutively expressing hepatitis C virus proteins.

Wölk B, Gremion C, Ivashkina N, Engler OB, Grabscheid B, Bieck E, Blum HE, Cerny A, Moradpour D.

J Gen Virol. 2005 Jun;86(Pt 6):1737-46.


HLA A2 restricted cytotoxic T lymphocyte responses to multiple hepatitis B surface antigen epitopes during hepatitis B virus infection.

Nayersina R, Fowler P, Guilhot S, Missale G, Cerny A, Schlicht HJ, Vitiello A, Chesnut R, Person JL, Redeker AG, Chisari FV.

J Immunol. 1993 May 15;150(10):4659-71.


Cytotoxic T lymphocyte response to hepatitis C virus-derived peptides containing the HLA A2.1 binding motif.

Cerny A, McHutchison JG, Pasquinelli C, Brown ME, Brothers MA, Grabscheid B, Fowler P, Houghton M, Chisari FV.

J Clin Invest. 1995 Feb;95(2):521-30.


Identification of immunodominant hepatitis C virus (HCV)-specific cytotoxic T-cell epitopes by stimulation with endogenously synthesized HCV antigens.

Urbani S, Uggeri J, Matsuura Y, Miyamura T, Penna A, Boni C, Ferrari C.

Hepatology. 2001 Jun;33(6):1533-43.


Hepatitis C virus mutation affects proteasomal epitope processing.

Seifert U, Liermann H, Racanelli V, Halenius A, Wiese M, Wedemeyer H, Ruppert T, Rispeter K, Henklein P, Sijts A, Hengel H, Kloetzel PM, Rehermann B.

J Clin Invest. 2004 Jul;114(2):250-9.


Induction of cytotoxic T cells to a cross-reactive epitope in the hepatitis C virus nonstructural RNA polymerase-like protein.

Shirai M, Akatsuka T, Pendleton CD, Houghten R, Wychowski C, Mihalik K, Feinstone S, Berzofsky JA.

J Virol. 1992 Jul;66(7):4098-106.


Different hepatitis C virus nonstructural protein 3 (Ns3)-DNA-expressing vaccines induce in HLA-A2.1 transgenic mice stable cytotoxic T lymphocytes that target one major epitope.

Brinster C, Muguet S, Lone YC, Boucreux D, Renard N, Fournillier A, Lemonnier F, Inchauspé G.

Hepatology. 2001 Dec;34(6):1206-17.


Primary and memory T cell responses induced by hepatitis C virus multiepitope long peptides.

Fournillier A, Dupeyrot P, Martin P, Parroche P, Pajot A, Chatel L, Fatmi A, Gerossier E, Bain C, Lone YC, Trépo C, Inchauspé G.

Vaccine. 2006 Apr 12;24(16):3153-64. Epub 2006 Jan 31.


Patients with chronic hepatitis C have circulating cytotoxic T cells which recognize hepatitis C virus-encoded peptides binding to HLA-A2.1 molecules.

Battegay M, Fikes J, Di Bisceglie AM, Wentworth PA, Sette A, Celis E, Ching WM, Grakoui A, Rice CM, Kurokohchi K, et al.

J Virol. 1995 Apr;69(4):2462-70.

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