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The virion host shutoff protein of herpes simplex virus 1 blocks the replication-independent activation of NF-κB in dendritic cells in the absence of type I interferon signaling.

Cotter CR, Kim WK, Nguyen ML, Yount JS, López CB, Blaho JA, Moran TM.

J Virol. 2011 Dec;85(23):12662-72. doi: 10.1128/JVI.05557-11. Epub 2011 Sep 21.


The virion host shut-off (vhs) protein blocks a TLR-independent pathway of herpes simplex virus type 1 recognition in human and mouse dendritic cells.

Cotter CR, Nguyen ML, Yount JS, López CB, Blaho JA, Moran TM.

PLoS One. 2010 Feb 18;5(2):e8684. doi: 10.1371/journal.pone.0008684.


Selective ablation of virion host shutoff protein RNase activity attenuates herpes simplex virus 2 in mice.

Korom M, Wylie KM, Morrison LA.

J Virol. 2008 Apr;82(7):3642-53. doi: 10.1128/JVI.02409-07. Epub 2008 Jan 30.


Herpes simplex virus virion host shutoff (vhs) activity alters periocular disease in mice.

Smith TJ, Ackland-Berglund CE, Leib DA.

J Virol. 2000 Apr;74(8):3598-604.


Defining the Role of Stress Granules in Innate Immune Suppression by the Herpes Simplex Virus 1 Endoribonuclease VHS.

Burgess HM, Mohr I.

J Virol. 2018 Jul 17;92(15). pii: e00829-18. doi: 10.1128/JVI.00829-18. Print 2018 Aug 1.


Deletion of the virion host shutoff protein (vhs) from herpes simplex virus (HSV) relieves the viral block to dendritic cell activation: potential of vhs- HSV vectors for dendritic cell-mediated immunotherapy.

Samady L, Costigliola E, MacCormac L, McGrath Y, Cleverley S, Lilley CE, Smith J, Latchman DS, Chain B, Coffin RS.

J Virol. 2003 Mar;77(6):3768-76.


Herpes simplex virus 1 counteracts tetherin restriction via its virion host shutoff activity.

Zenner HL, Mauricio R, Banting G, Crump CM.

J Virol. 2013 Dec;87(24):13115-23. doi: 10.1128/JVI.02167-13. Epub 2013 Sep 25.


The gamma 1 34.5 protein of herpes simplex virus 1 is required to interfere with dendritic cell maturation during productive infection.

Jin H, Ma Y, Prabhakar BS, Feng Z, Valyi-Nagy T, Yan Z, Verpooten D, Zhang C, Cao Y, He B.

J Virol. 2009 May;83(10):4984-94. doi: 10.1128/JVI.02535-08. Epub 2009 Mar 11.


The virion host shutoff RNase plays a key role in blocking the activation of protein kinase R in cells infected with herpes simplex virus 1.

Sciortino MT, Parisi T, Siracusano G, Mastino A, Taddeo B, Roizman B.

J Virol. 2013 Mar;87(6):3271-6. doi: 10.1128/JVI.03049-12. Epub 2013 Jan 9.


Herpes simplex virus 1 tegument protein US11 downmodulates the RLR signaling pathway via direct interaction with RIG-I and MDA-5.

Xing J, Wang S, Lin R, Mossman KL, Zheng C.

J Virol. 2012 Apr;86(7):3528-40. doi: 10.1128/JVI.06713-11. Epub 2012 Feb 1.


Herpes Simplex Virus 1 Serine Protease VP24 Blocks the DNA-Sensing Signal Pathway by Abrogating Activation of Interferon Regulatory Factor 3.

Zhang D, Su C, Zheng C.

J Virol. 2016 May 27;90(12):5824-5829. doi: 10.1128/JVI.00186-16. Print 2016 Jun 15.


Evidence for translational regulation by the herpes simplex virus virion host shutoff protein.

Saffran HA, Read GS, Smiley JR.

J Virol. 2010 Jun;84(12):6041-9. doi: 10.1128/JVI.01819-09. Epub 2010 Mar 31.


The Herpes Simplex Virus Virion Host Shutoff Protein Enhances Translation of Viral True Late mRNAs Independently of Suppressing Protein Kinase R and Stress Granule Formation.

Dauber B, Poon D, Dos Santos T, Duguay BA, Mehta N, Saffran HA, Smiley JR.

J Virol. 2016 Jun 10;90(13):6049-6057. doi: 10.1128/JVI.03180-15. Print 2016 Jul 1.

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