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Items: 1 to 20 of 217

1.

Toxoplasma gondii rhoptry kinase ROP16 activates STAT3 and STAT6 resulting in cytokine inhibition and arginase-1-dependent growth control.

Butcher BA, Fox BA, Rommereim LM, Kim SG, Maurer KJ, Yarovinsky F, Herbert DR, Bzik DJ, Denkers EY.

PLoS Pathog. 2011 Sep;7(9):e1002236. doi: 10.1371/journal.ppat.1002236. Epub 2011 Sep 8.

2.

Toxoplasma rhoptry protein 16 (ROP16) subverts host function by direct tyrosine phosphorylation of STAT6.

Ong YC, Reese ML, Boothroyd JC.

J Biol Chem. 2010 Sep 10;285(37):28731-40. doi: 10.1074/jbc.M110.112359. Epub 2010 Jul 12.

3.

Toxoplasma gondii rhoptry 16 kinase promotes host resistance to oral infection and intestinal inflammation only in the context of the dense granule protein GRA15.

Jensen KD, Hu K, Whitmarsh RJ, Hassan MA, Julien L, Lu D, Chen L, Hunter CA, Saeij JP.

Infect Immun. 2013 Jun;81(6):2156-67. doi: 10.1128/IAI.01185-12. Epub 2013 Apr 1.

4.

A single polymorphic amino acid on Toxoplasma gondii kinase ROP16 determines the direct and strain-specific activation of Stat3.

Yamamoto M, Standley DM, Takashima S, Saiga H, Okuyama M, Kayama H, Kubo E, Ito H, Takaura M, Matsuda T, Soldati-Favre D, Takeda K.

J Exp Med. 2009 Nov 23;206(12):2747-60. doi: 10.1084/jem.20091703. Epub 2009 Nov 9.

5.

Targeted disruption of CK1α in Toxoplasma gondii increases acute virulence in mice.

Wang Z, Wang S, Wang W, Gu Y, Liu H, Wei F, Liu Q.

Eur J Protistol. 2016 Oct;56:90-101. doi: 10.1016/j.ejop.2016.07.006. Epub 2016 Aug 4.

PMID:
27567091
6.

[Advances in research of Toxoplasma gondii rhoptry protein ROP16].

Liu GZ, Wang B, Wang HF.

Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2015 Apr;27(2):217-20. Review. Chinese.

PMID:
26263796
7.

Toxoplasma gondii genotype determines MyD88-dependent signaling in infected macrophages.

Kim L, Butcher BA, Lee CW, Uematsu S, Akira S, Denkers EY.

J Immunol. 2006 Aug 15;177(4):2584-91.

8.

The Toxoplasma gondii Rhoptry Kinome Is Essential for Chronic Infection.

Fox BA, Rommereim LM, Guevara RB, Falla A, Hortua Triana MA, Sun Y, Bzik DJ.

MBio. 2016 May 10;7(3). pii: e00193-16. doi: 10.1128/mBio.00193-16.

9.

Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologue.

Saeij JP, Coller S, Boyle JP, Jerome ME, White MW, Boothroyd JC.

Nature. 2007 Jan 18;445(7125):324-7. Epub 2006 Dec 20.

10.

Neospora caninum ROP16 play an important role in the pathogenicity by phosphorylating host cell STAT3.

Ma L, Liu G, Liu J, Li M, Zhang H, Tang D, Liu Q.

Vet Parasitol. 2017 Aug 30;243:135-147. doi: 10.1016/j.vetpar.2017.04.020. Epub 2017 May 19.

PMID:
28807283
11.

Arginine usage in mycobacteria-infected macrophages depends on autocrine-paracrine cytokine signaling.

Qualls JE, Neale G, Smith AM, Koo MS, DeFreitas AA, Zhang H, Kaplan G, Watowich SS, Murray PJ.

Sci Signal. 2010 Aug 17;3(135):ra62. doi: 10.1126/scisignal.2000955.

12.

Toxoplasma gondii Inactivates Human Plasmacytoid Dendritic Cells by Functional Mimicry of IL-10.

Pierog PL, Zhao Y, Singh S, Dai J, Yap GS, Fitzgerald-Bocarsly P.

J Immunol. 2018 Jan 1;200(1):186-195. doi: 10.4049/jimmunol.1701045. Epub 2017 Nov 27.

PMID:
29180487
13.

Progressive visceral leishmaniasis is driven by dominant parasite-induced STAT6 activation and STAT6-dependent host arginase 1 expression.

Osorio EY, Zhao W, Espitia C, Saldarriaga O, Hawel L, Byus CV, Travi BL, Melby PC.

PLoS Pathog. 2012 Jan;8(1):e1002417. doi: 10.1371/journal.ppat.1002417. Epub 2012 Jan 19.

14.

Toxoplasma gondii triggers phosphorylation and nuclear translocation of dendritic cell STAT1 while simultaneously blocking IFNγ-induced STAT1 transcriptional activity.

Schneider AG, Abi Abdallah DS, Butcher BA, Denkers EY.

PLoS One. 2013;8(3):e60215. doi: 10.1371/journal.pone.0060215. Epub 2013 Mar 20.

15.
16.

IL-10-independent STAT3 activation by Toxoplasma gondii mediates suppression of IL-12 and TNF-alpha in host macrophages.

Butcher BA, Kim L, Panopoulos AD, Watowich SS, Murray PJ, Denkers EY.

J Immunol. 2005 Mar 15;174(6):3148-52.

17.

An inside job: hacking into Janus kinase/signal transducer and activator of transcription signaling cascades by the intracellular protozoan Toxoplasma gondii.

Denkers EY, Bzik DJ, Fox BA, Butcher BA.

Infect Immun. 2012 Feb;80(2):476-82. doi: 10.1128/IAI.05974-11. Epub 2011 Nov 21. Review.

19.

Natural killer cell intrinsic toll-like receptor MyD88 signaling contributes to IL-12-dependent IFN-γ production by mice during infection with Toxoplasma gondii.

Ge Y, Chen J, Qiu X, Zhang J, Cui L, Qi Y, Liu X, Qiu J, Shi Z, Lun Z, Shen J, Wang Y.

Int J Parasitol. 2014 Jun;44(7):475-84. doi: 10.1016/j.ijpara.2014.03.004. Epub 2014 Apr 13.

PMID:
24727091
20.

Growth factor and Th2 cytokine signaling pathways converge at STAT6 to promote arginase expression in progressive experimental visceral leishmaniasis.

Osorio EY, Travi BL, da Cruz AM, Saldarriaga OA, Medina AA, Melby PC.

PLoS Pathog. 2014 Jun 26;10(6):e1004165. doi: 10.1371/journal.ppat.1004165. eCollection 2014 Jun.

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