Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 146


NEMO is a key component of NF-κB- and IRF-3-dependent TLR3-mediated immunity to herpes simplex virus.

Audry M, Ciancanelli M, Yang K, Cobat A, Chang HH, Sancho-Shimizu V, Lorenzo L, Niehues T, Reichenbach J, Li XX, Israel A, Abel L, Casanova JL, Zhang SY, Jouanguy E, Puel A.

J Allergy Clin Immunol. 2011 Sep;128(3):610-7.e1-4. doi: 10.1016/j.jaci.2011.04.059. Epub 2011 Jul 1.


Heterozygous TBK1 mutations impair TLR3 immunity and underlie herpes simplex encephalitis of childhood.

Herman M, Ciancanelli M, Ou YH, Lorenzo L, Klaudel-Dreszler M, Pauwels E, Sancho-Shimizu V, Pérez de Diego R, Abhyankar A, Israelsson E, Guo Y, Cardon A, Rozenberg F, Lebon P, Tardieu M, Heropolitanska-Pliszka E, Chaussabel D, White MA, Abel L, Zhang SY, Casanova JL.

J Exp Med. 2012 Aug 27;209(9):1567-82. doi: 10.1084/jem.20111316. Epub 2012 Jul 30.


Herpes simplex virus encephalitis in a patient with complete TLR3 deficiency: TLR3 is otherwise redundant in protective immunity.

Guo Y, Audry M, Ciancanelli M, Alsina L, Azevedo J, Herman M, Anguiano E, Sancho-Shimizu V, Lorenzo L, Pauwels E, Philippe PB, Pérez de Diego R, Cardon A, Vogt G, Picard C, Andrianirina ZZ, Rozenberg F, Lebon P, Plancoulaine S, Tardieu M, Valérie Doireau, Jouanguy E, Chaussabel D, Geissmann F, Abel L, Casanova JL, Zhang SY.

J Exp Med. 2011 Sep 26;208(10):2083-98. doi: 10.1084/jem.20101568. Epub 2011 Sep 12.


Impaired intrinsic immunity to HSV-1 in human iPSC-derived TLR3-deficient CNS cells.

Lafaille FG, Pessach IM, Zhang SY, Ciancanelli MJ, Herman M, Abhyankar A, Ying SW, Keros S, Goldstein PA, Mostoslavsky G, Ordovas-Montanes J, Jouanguy E, Plancoulaine S, Tu E, Elkabetz Y, Al-Muhsen S, Tardieu M, Schlaeger TM, Daley GQ, Abel L, Casanova JL, Studer L, Notarangelo LD.

Nature. 2012 Nov 29;491(7426):769-73. doi: 10.1038/nature11583. Epub 2012 Oct 28.


Genetic susceptibility to herpes simplex virus 1 encephalitis in mice and humans.

Sancho-Shimizu V, Zhang SY, Abel L, Tardieu M, Rozenberg F, Jouanguy E, Casanova JL.

Curr Opin Allergy Clin Immunol. 2007 Dec;7(6):495-505. Review.


SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways.

Huang J, Liu T, Xu LG, Chen D, Zhai Z, Shu HB.

EMBO J. 2005 Dec 7;24(23):4018-28. Epub 2005 Nov 10.


Protein kinase Calpha is involved in interferon regulatory factor 3 activation and type I interferon-beta synthesis.

Johnson J, Albarani V, Nguyen M, Goldman M, Willems F, Aksoy E.

J Biol Chem. 2007 May 18;282(20):15022-32. Epub 2007 Feb 12.


Induction of interferon-λ contributes to TLR3 and RIG-I activation-mediated inhibition of herpes simplex virus type 2 replication in human cervical epithelial cells.

Zhou L, Li JL, Zhou Y, Liu JB, Zhuang K, Gao JF, Liu S, Sang M, Wu JG, Ho WZ.

Mol Hum Reprod. 2015 Dec;21(12):917-29. doi: 10.1093/molehr/gav058. Epub 2015 Oct 26.


IRF-1 inhibits NF-κB activity, suppresses TRAF2 and cIAP1 and induces breast cancer cell specific growth inhibition.

Armstrong MJ, Stang MT, Liu Y, Yan J, Pizzoferrato E, Yim JH.

Cancer Biol Ther. 2015;16(7):1029-41. doi: 10.1080/15384047.2015.1046646.


Mendelian predisposition to herpes simplex encephalitis.

Zhang SY, Abel L, Casanova JL.

Handb Clin Neurol. 2013;112:1091-7. doi: 10.1016/B978-0-444-52910-7.00027-1. Review.


Toll-like receptor 3-mediated activation of NF-kappaB and IRF3 diverges at Toll-IL-1 receptor domain-containing adapter inducing IFN-beta.

Jiang Z, Mak TW, Sen G, Li X.

Proc Natl Acad Sci U S A. 2004 Mar 9;101(10):3533-8. Epub 2004 Feb 24.


Immune deficiency caused by impaired expression of nuclear factor-kappaB essential modifier (NEMO) because of a mutation in the 5' untranslated region of the NEMO gene.

Mooster JL, Cancrini C, Simonetti A, Rossi P, Di Matteo G, Romiti ML, Di Cesare S, Notarangelo L, Geha RS, McDonald DR.

J Allergy Clin Immunol. 2010 Jul;126(1):127-32.e7. doi: 10.1016/j.jaci.2010.04.026. Epub 2010 Jun 12.


Alteration of TLR3 pathways by glucocorticoids may be responsible for immunosusceptibility of human corneal epithelial cells to viral infections.

Hara Y, Shiraishi A, Kobayashi T, Kadota Y, Shirakata Y, Hashimoto K, Ohashi Y.

Mol Vis. 2009 May 8;15:937-48.


The proteome of Toll-like receptor 3-stimulated human immortalized fibroblasts: implications for susceptibility to herpes simplex virus encephalitis.

Pérez de Diego R, Mulvey C, Crawford M, Trotter MW, Lorenzo L, Sancho-Shimizu V, Abel L, Zhang SY, Casanova JL, Godovac-Zimmermann J.

J Allergy Clin Immunol. 2013 Apr;131(4):1157-66. doi: 10.1016/j.jaci.2013.01.008. Epub 2013 Feb 21.


Homo-oligomerization is essential for Toll/interleukin-1 receptor domain-containing adaptor molecule-1-mediated NF-kappaB and interferon regulatory factor-3 activation.

Funami K, Sasai M, Oshiumi H, Seya T, Matsumoto M.

J Biol Chem. 2008 Jun 27;283(26):18283-91. doi: 10.1074/jbc.M801013200. Epub 2008 May 1.


Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation.

Cusson-Hermance N, Khurana S, Lee TH, Fitzgerald KA, Kelliher MA.

J Biol Chem. 2005 Nov 4;280(44):36560-6. Epub 2005 Aug 22.


Scaffolding adaptor protein Gab1 is required for TLR3/4- and RIG-I-mediated production of proinflammatory cytokines and type I IFN in macrophages.

Zheng Y, An H, Yao M, Hou J, Yu Y, Feng G, Cao X.

J Immunol. 2010 Jun 1;184(11):6447-56. doi: 10.4049/jimmunol.0901750. Epub 2010 Apr 30.


TRAF6 establishes innate immune responses by activating NF-kappaB and IRF7 upon sensing cytosolic viral RNA and DNA.

Konno H, Yamamoto T, Yamazaki K, Gohda J, Akiyama T, Semba K, Goto H, Kato A, Yujiri T, Imai T, Kawaguchi Y, Su B, Takeuchi O, Akira S, Tsunetsugu-Yokota Y, Inoue J.

PLoS One. 2009 May 25;4(5):e5674. doi: 10.1371/journal.pone.0005674.


Astrocyte indoleamine 2,3-dioxygenase is induced by the TLR3 ligand poly(I:C): mechanism of induction and role in antiviral response.

Suh HS, Zhao ML, Rivieccio M, Choi S, Connolly E, Zhao Y, Takikawa O, Brosnan CF, Lee SC.

J Virol. 2007 Sep;81(18):9838-50. Epub 2007 Jul 11.


Supplemental Content

Support Center