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Items: 1 to 20 of 147


Genome-wide pharmacogenetics of antidepressant response in the GENDEP project.

Uher R, Perroud N, Ng MY, Hauser J, Henigsberg N, Maier W, Mors O, Placentino A, Rietschel M, Souery D, Zagar T, Czerski PM, Jerman B, Larsen ER, Schulze TG, Zobel A, Cohen-Woods S, Pirlo K, Butler AW, Muglia P, Barnes MR, Lathrop M, Farmer A, Breen G, Aitchison KJ, Craig I, Lewis CM, McGuffin P.

Am J Psychiatry. 2010 May;167(5):555-64. doi: 10.1176/appi.ajp.2009.09070932. Epub 2010 Apr 1.


DNA methylation in interleukin-11 predicts clinical response to antidepressants in GENDEP.

Powell TR, Smith RG, Hackinger S, Schalkwyk LC, Uher R, McGuffin P, Mill J, Tansey KE.

Transl Psychiatry. 2013 Sep 3;3:e300. doi: 10.1038/tp.2013.73.


Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.

GENDEP Investigators; MARS Investigators; STAR*D Investigators.

Am J Psychiatry. 2013 Feb;170(2):207-17. doi: 10.1176/appi.ajp.2012.12020237.


Convergent animal and human evidence suggests a role of PPM1A gene in response to antidepressants.

Malki K, Uher R, Paya-Cano J, Binder E, Rietschel M, Zobel A, Mors O, Hauser J, Henigsberg N, Jerman B, Souery D, Placentino A, Ng MY, Cohen-Woods S, Sluyter F, Farmer A, Aitchison KJ, Craig IW, Lewis CM, McGuffin P, Schalkwyk LC.

Biol Psychiatry. 2011 Feb 15;69(4):360-5. doi: 10.1016/j.biopsych.2010.08.011. Epub 2010 Oct 20.


Genome-wide association study of increasing suicidal ideation during antidepressant treatment in the GENDEP project.

Perroud N, Uher R, Ng MY, Guipponi M, Hauser J, Henigsberg N, Maier W, Mors O, Gennarelli M, Rietschel M, Souery D, Dernovsek MZ, Stamp AS, Lathrop M, Farmer A, Breen G, Aitchison KJ, Lewis CM, Craig IW, McGuffin P.

Pharmacogenomics J. 2012 Feb;12(1):68-77. doi: 10.1038/tpj.2010.70. Epub 2010 Sep 28.


Genetic predictors of response to antidepressants in the GENDEP project.

Uher R, Huezo-Diaz P, Perroud N, Smith R, Rietschel M, Mors O, Hauser J, Maier W, Kozel D, Henigsberg N, Barreto M, Placentino A, Dernovsek MZ, Schulze TG, Kalember P, Zobel A, Czerski PM, Larsen ER, Souery D, Giovannini C, Gray JM, Lewis CM, Farmer A, Aitchison KJ, McGuffin P, Craig I.

Pharmacogenomics J. 2009 Aug;9(4):225-33. doi: 10.1038/tpj.2009.12. Epub 2009 Apr 14.


An inflammatory biomarker as a differential predictor of outcome of depression treatment with escitalopram and nortriptyline.

Uher R, Tansey KE, Dew T, Maier W, Mors O, Hauser J, Dernovsek MZ, Henigsberg N, Souery D, Farmer A, McGuffin P.

Am J Psychiatry. 2014 Dec 1;171(12):1278-86. doi: 10.1176/appi.ajp.2014.14010094. Epub 2014 Oct 31.


Early and delayed onset of response to antidepressants in individual trajectories of change during treatment of major depression: a secondary analysis of data from the Genome-Based Therapeutic Drugs for Depression (GENDEP) study.

Uher R, Mors O, Rietschel M, Rajewska-Rager A, Petrovic A, Zobel A, Henigsberg N, Mendlewicz J, Aitchison KJ, Farmer A, McGuffin P.

J Clin Psychiatry. 2011 Nov;72(11):1478-84. doi: 10.4088/JCP.10m06419.


Variation in GNB3 predicts response and adverse reactions to antidepressants.

Keers R, Bonvicini C, Scassellati C, Uher R, Placentino A, Giovannini C, Rietschel M, Henigsberg N, Kozel D, Mors O, Maier W, Hauser J, Souery D, Mendlewicz J, Schmäl C, Zobel A, Larsen ER, Szczepankiewicz A, Kovacic Z, Elkin A, Craig I, McGuffin P, Farmer AE, Aitchison KJ, Gennarelli M.

J Psychopharmacol. 2011 Jul;25(7):867-74. doi: 10.1177/0269881110376683. Epub 2010 Sep 8.


Trajectories of change in depression severity during treatment with antidepressants.

Uher R, Muthén B, Souery D, Mors O, Jaracz J, Placentino A, Petrovic A, Zobel A, Henigsberg N, Rietschel M, Aitchison KJ, Farmer A, McGuffin P.

Psychol Med. 2010 Aug;40(8):1367-77. doi: 10.1017/S0033291709991528. Epub 2009 Oct 29.


Non-random dropout and the relative efficacy of escitalopram and nortriptyline in treating major depressive disorder.

Power RA, Muthén B, Henigsberg N, Mors O, Placentino A, Mendlewicz J, Maier W, McGuffin P, Lewis CM, Uher R.

J Psychiatr Res. 2012 Oct;46(10):1333-8. doi: 10.1016/j.jpsychires.2012.06.014. Epub 2012 Jul 6.


Body weight as a predictor of antidepressant efficacy in the GENDEP project.

Uher R, Mors O, Hauser J, Rietschel M, Maier W, Kozel D, Henigsberg N, Souery D, Placentino A, Perroud N, Dernovsek MZ, Strohmaier J, Larsen ER, Zobel A, Leszczynska-Rodziewicz A, Kalember P, Pedrini L, Linotte S, Gunasinghe C, Aitchison KJ, McGuffin P, Farmer A.

J Affect Disord. 2009 Nov;118(1-3):147-54. doi: 10.1016/j.jad.2009.02.013. Epub 2009 Mar 9.


New insights into the pharmacogenomics of antidepressant response from the GENDEP and STAR*D studies: rare variant analysis and high-density imputation.

Fabbri C, Tansey KE, Perlis RH, Hauser J, Henigsberg N, Maier W, Mors O, Placentino A, Rietschel M, Souery D, Breen G, Curtis C, Sang-Hyuk L, Newhouse S, Patel H, Guipponi M, Perroud N, Bondolfi G, O'Donovan M, Lewis G, Biernacka JM, Weinshilboum RM, Farmer A, Aitchison KJ, Craig I, McGuffin P, Uher R, Lewis CM.

Pharmacogenomics J. 2018 May 22;18(3):413-421. doi: 10.1038/tpj.2017.44. Epub 2017 Nov 21.


A genome-wide association study of a sustained pattern of antidepressant response.

Hunter AM, Leuchter AF, Power RA, Muthén B, McGrath PJ, Lewis CM, Cook IA, Garriock HA, McGuffin P, Uher R, Hamilton SP.

J Psychiatr Res. 2013 Sep;47(9):1157-65. doi: 10.1016/j.jpsychires.2013.05.002. Epub 2013 May 30.


Genetic predictors of increase in suicidal ideation during antidepressant treatment in the GENDEP project.

Perroud N, Aitchison KJ, Uher R, Smith R, Huezo-Diaz P, Marusic A, Maier W, Mors O, Placentino A, Henigsberg N, Rietschel M, Hauser J, Souery D, Kapelski P, Bonvicini C, Zobel A, Jorgensen L, Petrovic A, Kalember P, Schulze TG, Gupta B, Gray J, Lewis CM, Farmer AE, McGuffin P, Craig I.

Neuropsychopharmacology. 2009 Nov;34(12):2517-28. doi: 10.1038/npp.2009.81. Epub 2009 Jul 29.


A genomewide association study of citalopram response in major depressive disorder.

Garriock HA, Kraft JB, Shyn SI, Peters EJ, Yokoyama JS, Jenkins GD, Reinalda MS, Slager SL, McGrath PJ, Hamilton SP.

Biol Psychiatry. 2010 Jan 15;67(2):133-8. doi: 10.1016/j.biopsych.2009.08.029.


Depression symptom dimensions as predictors of antidepressant treatment outcome: replicable evidence for interest-activity symptoms.

Uher R, Perlis RH, Henigsberg N, Zobel A, Rietschel M, Mors O, Hauser J, Dernovsek MZ, Souery D, Bajs M, Maier W, Aitchison KJ, Farmer A, McGuffin P.

Psychol Med. 2012 May;42(5):967-80. doi: 10.1017/S0033291711001905. Epub 2011 Sep 20.


Tumor necrosis factor and its targets in the inflammatory cytokine pathway are identified as putative transcriptomic biomarkers for escitalopram response.

Powell TR, Schalkwyk LC, Heffernan AL, Breen G, Lawrence T, Price T, Farmer AE, Aitchison KJ, Craig IW, Danese A, Lewis C, McGuffin P, Uher R, Tansey KE, D'Souza UM.

Eur Neuropsychopharmacol. 2013 Sep;23(9):1105-14. doi: 10.1016/j.euroneuro.2012.09.009. Epub 2012 Nov 9.


Analysis of 23andMe antidepressant efficacy survey data: implication of circadian rhythm and neuroplasticity in bupropion response.

Li QS, Tian C, Seabrook GR, Drevets WC, Narayan VA.

Transl Psychiatry. 2016 Sep 13;6(9):e889. doi: 10.1038/tp.2016.171.


A genomewide association study points to multiple loci that predict antidepressant drug treatment outcome in depression.

Ising M, Lucae S, Binder EB, Bettecken T, Uhr M, Ripke S, Kohli MA, Hennings JM, Horstmann S, Kloiber S, Menke A, Bondy B, Rupprecht R, Domschke K, Baune BT, Arolt V, Rush AJ, Holsboer F, Müller-Myhsok B.

Arch Gen Psychiatry. 2009 Sep;66(9):966-975. doi: 10.1001/archgenpsychiatry.2009.95.

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