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Items: 1 to 20 of 133

1.
2.

Serotonin and cocaine-sensitive inactivation of human serotonin transporters by methanethiosulfonates targeted to transmembrane domain I.

Henry LK, Adkins EM, Han Q, Blakely RD.

J Biol Chem. 2003 Sep 26;278(39):37052-63. Epub 2003 Jul 17.

3.

Tyr-95 and Ile-172 in transmembrane segments 1 and 3 of human serotonin transporters interact to establish high affinity recognition of antidepressants.

Henry LK, Field JR, Adkins EM, Parnas ML, Vaughan RA, Zou MF, Newman AH, Blakely RD.

J Biol Chem. 2006 Jan 27;281(4):2012-23. Epub 2005 Nov 3.

4.

Identification of an allosteric modulator of the serotonin transporter with novel mechanism of action.

Kortagere S, Fontana AC, Rose DR, Mortensen OV.

Neuropharmacology. 2013 Sep;72:282-90. doi: 10.1016/j.neuropharm.2013.04.026. Epub 2013 Apr 28.

PMID:
23632081
5.

The external gate of the human and Drosophila serotonin transporters requires a basic/acidic amino acid pair for 3,4-methylenedioxymethamphetamine (MDMA) translocation and the induction of substrate efflux.

Sealover NR, Felts B, Kuntz CP, Jarrard RE, Hockerman GH, Lamb PW, Barker EL, Henry LK.

Biochem Pharmacol. 2016 Nov 15;120:46-55. doi: 10.1016/j.bcp.2016.09.006. Epub 2016 Sep 13. Erratum in: Biochem Pharmacol. 2017 Nov 28;147:9.

PMID:
27638414
6.

The cytoplasmic substrate permeation pathway of serotonin transporter.

Zhang YW, Rudnick G.

J Biol Chem. 2006 Nov 24;281(47):36213-20. Epub 2006 Sep 28.

7.

Substrate and Inhibitor-Specific Conformational Changes in the Human Serotonin Transporter Revealed by Voltage-Clamp Fluorometry.

Söderhielm PC, Andersen J, Munro L, Nielsen AT, Kristensen AS.

Mol Pharmacol. 2015 Oct;88(4):676-88. doi: 10.1124/mol.115.099911. Epub 2015 Jul 14.

8.

Structure and function of extracellular loop 4 of the serotonin transporter as revealed by cysteine-scanning mutagenesis.

Mitchell SM, Lee E, Garcia ML, Stephan MM.

J Biol Chem. 2004 Jun 4;279(23):24089-99. Epub 2004 Mar 31.

9.

Y95 and E444 interaction required for high-affinity S-citalopram binding in the human serotonin transporter.

Combs S, Kaufmann K, Field JR, Blakely RD, Meiler J.

ACS Chem Neurosci. 2011 Feb 16;2(2):75-81. doi: 10.1021/cn100066p. Epub 2010 Oct 27. Review.

10.

Unbiased simulations reveal the inward-facing conformation of the human serotonin transporter and Na(+) ion release.

Koldsø H, Noer P, Grouleff J, Autzen HE, Sinning S, Schiøtt B.

PLoS Comput Biol. 2011 Oct;7(10):e1002246. doi: 10.1371/journal.pcbi.1002246. Epub 2011 Oct 27.

11.

Acceleration of serotonin transporter transport-associated current by 3,4-methylenedioxymethamphetamine (MDMA) under acidic conditions.

Yamauchi Y, Izumi T, Unemura K, Uenishi Y, Nakagawa T, Kaneko S.

Neurosci Lett. 2007 Nov 27;428(2-3):72-6. Epub 2007 Sep 26.

PMID:
17949903
12.

Structural determinants of species-selective substrate recognition in human and Drosophila serotonin transporters revealed through computational docking studies.

Kaufmann KW, Dawson ES, Henry LK, Field JR, Blakely RD, Meiler J.

Proteins. 2009 Feb 15;74(3):630-42. doi: 10.1002/prot.22178.

13.
14.

Location of the antidepressant binding site in the serotonin transporter: importance of Ser-438 in recognition of citalopram and tricyclic antidepressants.

Andersen J, Taboureau O, Hansen KB, Olsen L, Egebjerg J, Strømgaard K, Kristensen AS.

J Biol Chem. 2009 Apr 10;284(15):10276-84. doi: 10.1074/jbc.M806907200. Epub 2009 Feb 12.

15.

Helix XI contributes to the entrance of the serotonin transporter permeation pathway.

Torres-Altoro MI, White KJ, Rodríguez GJ, Nichols DE, Barker EL.

Protein Sci. 2008 Oct;17(10):1761-70. doi: 10.1110/ps.036749.108. Epub 2008 Jul 15.

16.

Molecular dynamics simulations of Na+/Cl(-)-dependent neurotransmitter transporters in a membrane-aqueous system.

Jørgensen AM, Tagmose L, Jørgensen AM, Bøgesø KP, Peters GH.

ChemMedChem. 2007 Jun;2(6):827-40.

PMID:
17436258
17.

Comparative molecular field analysis using selectivity fields reveals residues in the third transmembrane helix of the serotonin transporter associated with substrate and antagonist recognition.

Walline CC, Nichols DE, Carroll FI, Barker EL.

J Pharmacol Exp Ther. 2008 Jun;325(3):791-800. doi: 10.1124/jpet.108.136200. Epub 2008 Mar 19.

19.

Structural analysis of the extracellular entrance to the serotonin transporter permeation pathway.

Torres-Altoro MI, Kuntz CP, Nichols DE, Barker EL.

J Biol Chem. 2010 May 14;285(20):15369-79. doi: 10.1074/jbc.M109.088138. Epub 2010 Mar 19.

20.

Cholesterol binding to a conserved site modulates the conformation, pharmacology, and transport kinetics of the human serotonin transporter.

Laursen L, Severinsen K, Kristensen KB, Periole X, Overby M, Müller HK, Schiøtt B, Sinning S.

J Biol Chem. 2018 Mar 9;293(10):3510-3523. doi: 10.1074/jbc.M117.809046. Epub 2018 Jan 19.

PMID:
29352106

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