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Items: 1 to 20 of 125

1.

Cortical kynurenine pathway metabolism: a novel target for cognitive enhancement in Schizophrenia.

Wonodi I, Schwarcz R.

Schizophr Bull. 2010 Mar;36(2):211-8. doi: 10.1093/schbul/sbq002. Epub 2010 Feb 10. Review.

2.

Acute elevations of brain kynurenic acid impair cognitive flexibility: normalization by the alpha7 positive modulator galantamine.

Alexander KS, Wu HQ, Schwarcz R, Bruno JP.

Psychopharmacology (Berl). 2012 Apr;220(3):627-37. doi: 10.1007/s00213-011-2539-2. Epub 2011 Oct 26.

3.

The astrocyte-derived alpha7 nicotinic receptor antagonist kynurenic acid controls extracellular glutamate levels in the prefrontal cortex.

Wu HQ, Pereira EF, Bruno JP, Pellicciari R, Albuquerque EX, Schwarcz R.

J Mol Neurosci. 2010 Jan;40(1-2):204-10. doi: 10.1007/s12031-009-9235-2. Epub 2009 Aug 19.

4.

Elevations of endogenous kynurenic acid produce spatial working memory deficits.

Chess AC, Simoni MK, Alling TE, Bucci DJ.

Schizophr Bull. 2007 May;33(3):797-804. Epub 2006 Aug 18.

5.

Astrocyte-derived kynurenic acid modulates basal and evoked cortical acetylcholine release.

Zmarowski A, Wu HQ, Brooks JM, Potter MC, Pellicciari R, Schwarcz R, Bruno JP.

Eur J Neurosci. 2009 Feb;29(3):529-38. doi: 10.1111/j.1460-9568.2008.06594.x.

PMID:
19187269
6.

Impaired kynurenine pathway metabolism in the prefrontal cortex of individuals with schizophrenia.

Sathyasaikumar KV, Stachowski EK, Wonodi I, Roberts RC, Rassoulpour A, McMahon RP, Schwarcz R.

Schizophr Bull. 2011 Nov;37(6):1147-56. doi: 10.1093/schbul/sbq112. Epub 2010 Oct 29.

7.

Endogenous kynurenic acid regulates extracellular GABA levels in the rat prefrontal cortex.

Beggiato S, Tanganelli S, Fuxe K, Antonelli T, Schwarcz R, Ferraro L.

Neuropharmacology. 2014 Jul;82:11-8. doi: 10.1016/j.neuropharm.2014.02.019. Epub 2014 Mar 7.

PMID:
24607890
8.

A systemically-available kynurenine aminotransferase II (KAT II) inhibitor restores nicotine-evoked glutamatergic activity in the cortex of rats.

Koshy Cherian A, Gritton H, Johnson DE, Young D, Kozak R, Sarter M.

Neuropharmacology. 2014 Jul;82:41-8. doi: 10.1016/j.neuropharm.2014.03.004. Epub 2014 Mar 16.

9.

Exposure to kynurenic acid during adolescence produces memory deficits in adulthood.

Akagbosu CO, Evans GC, Gulick D, Suckow RF, Bucci DJ.

Schizophr Bull. 2012 Jun;38(4):769-78. doi: 10.1093/schbul/sbq151. Epub 2010 Dec 20.

10.

Elevated levels of kynurenic acid during gestation produce neurochemical, morphological, and cognitive deficits in adulthood: implications for schizophrenia.

Pershing ML, Bortz DM, Pocivavsek A, Fredericks PJ, Jørgensen CV, Vunck SA, Leuner B, Schwarcz R, Bruno JP.

Neuropharmacology. 2015 Mar;90:33-41. doi: 10.1016/j.neuropharm.2014.10.017. Epub 2014 Nov 1.

11.

Prenatal kynurenine exposure in rats: age-dependent changes in NMDA receptor expression and conditioned fear responding.

Pershing ML, Phenis D, Valentini V, Pocivavsek A, Lindquist DH, Schwarcz R, Bruno JP.

Psychopharmacology (Berl). 2016 Oct;233(21-22):3725-3735. Epub 2016 Aug 16.

12.

Pre- and postnatal exposure to kynurenine causes cognitive deficits in adulthood.

Pocivavsek A, Wu HQ, Elmer GI, Bruno JP, Schwarcz R.

Eur J Neurosci. 2012 May;35(10):1605-12. doi: 10.1111/j.1460-9568.2012.08064.x. Epub 2012 Apr 20.

13.

Inhibition of Large Neutral Amino Acid Transporters Suppresses Kynurenic Acid Production Via Inhibition of Kynurenine Uptake in Rodent Brain.

Sekine A, Kuroki Y, Urata T, Mori N, Fukuwatari T.

Neurochem Res. 2016 Sep;41(9):2256-66. doi: 10.1007/s11064-016-1940-y. Epub 2016 May 9.

PMID:
27161376
14.

Reduction of brain kynurenic acid improves cognitive function.

Kozak R, Campbell BM, Strick CA, Horner W, Hoffmann WE, Kiss T, Chapin DS, McGinnis D, Abbott AL, Roberts BM, Fonseca K, Guanowsky V, Young DA, Seymour PA, Dounay A, Hajos M, Williams GV, Castner SA.

J Neurosci. 2014 Aug 6;34(32):10592-602. doi: 10.1523/JNEUROSCI.1107-14.2014.

15.

Role of the NMDA-receptor in Prepulse Inhibition in the Rat.

Linderholm K, Powell S, Olsson E, Holtze M, Snodgrass R, Erhardt S.

Int J Tryptophan Res. 2010;3:1-12. Epub 2010 Feb 12.

16.

Cortical kynurenic acid bi-directionally modulates prefrontal glutamate levels as assessed by microdialysis and rapid electrochemistry.

Konradsson-Geuken A, Wu HQ, Gash CR, Alexander KS, Campbell A, Sozeri Y, Pellicciari R, Schwarcz R, Bruno JP.

Neuroscience. 2010 Sep 15;169(4):1848-59. doi: 10.1016/j.neuroscience.2010.05.052. Epub 2010 Jun 19.

17.

Continuous kynurenine administration during the prenatal period, but not during adolescence, causes learning and memory deficits in adult rats.

Pocivavsek A, Thomas MA, Elmer GI, Bruno JP, Schwarcz R.

Psychopharmacology (Berl). 2014 Jul;231(14):2799-809. doi: 10.1007/s00213-014-3452-2. Epub 2014 Mar 4.

18.

Preferential Disruption of Prefrontal GABAergic Function by Nanomolar Concentrations of the α7nACh Negative Modulator Kynurenic Acid.

Flores-Barrera E, Thomases DR, Cass DK, Bhandari A, Schwarcz R, Bruno JP, Tseng KY.

J Neurosci. 2017 Aug 16;37(33):7921-7929. doi: 10.1523/JNEUROSCI.0932-17.2017. Epub 2017 Jul 20.

19.

Early developmental elevations of brain kynurenic acid impair cognitive flexibility in adults: reversal with galantamine.

Alexander KS, Pocivavsek A, Wu HQ, Pershing ML, Schwarcz R, Bruno JP.

Neuroscience. 2013 May 15;238:19-28. doi: 10.1016/j.neuroscience.2013.01.063. Epub 2013 Feb 6.

20.

Regulation of GABAergic inputs to CA1 pyramidal neurons by nicotinic receptors and kynurenic acid.

Banerjee J, Alkondon M, Pereira EF, Albuquerque EX.

J Pharmacol Exp Ther. 2012 May;341(2):500-9. doi: 10.1124/jpet.111.189860. Epub 2012 Feb 17.

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