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Items: 1 to 20 of 85

1.

The two enantiomers of citalopram bind to the human serotonin transporter in reversed orientations.

Koldsø H, Severinsen K, Tran TT, Celik L, Jensen HH, Wiborg O, Schiøtt B, Sinning S.

J Am Chem Soc. 2010 Feb 3;132(4):1311-22. doi: 10.1021/ja906923j.

PMID:
20055463
2.

Binding of serotonin to the human serotonin transporter. Molecular modeling and experimental validation.

Celik L, Sinning S, Severinsen K, Hansen CG, Møller MS, Bols M, Wiborg O, Schiøtt B.

J Am Chem Soc. 2008 Mar 26;130(12):3853-65. doi: 10.1021/ja076403h. Epub 2008 Mar 4.

PMID:
18314975
3.

[Escitalopram: a selective inhibitor and allosteric modulator of the serotonin transporter].

Mnie-Filali O, El Mansari M, Scarna H, Zimmer L, Sánchez C, Haddjeri N.

Encephale. 2007 Dec;33(6):965-72. doi: 10.1016/j.encep.2007.11.001. Epub 2007 Dec 11. Review. French.

PMID:
18789789
4.

Allosteric effects of R- and S-citalopram on the human 5-HT transporter: evidence for distinct high- and low-affinity binding sites.

Plenge P, Gether U, Rasmussen SG.

Eur J Pharmacol. 2007 Jul 12;567(1-2):1-9. Epub 2007 Apr 14.

PMID:
17499240
5.

Mutational mapping and modeling of the binding site for (S)-citalopram in the human serotonin transporter.

Andersen J, Olsen L, Hansen KB, Taboureau O, Jørgensen FS, Jørgensen AM, Bang-Andersen B, Egebjerg J, Strømgaard K, Kristensen AS.

J Biol Chem. 2010 Jan 15;285(3):2051-63. doi: 10.1074/jbc.M109.072587. Epub 2009 Nov 5.

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8.

An allosteric binding site at the human serotonin transporter mediates the inhibition of escitalopram by R-citalopram: kinetic binding studies with the ALI/VFL-SI/TT mutant.

Zhong H, Hansen KB, Boyle NJ, Han K, Muske G, Huang X, Egebjerg J, Sánchez C.

Neurosci Lett. 2009 Oct 25;462(3):207-12. doi: 10.1016/j.neulet.2009.07.030. Epub 2009 Jul 16.

PMID:
19616061
9.

Molecular mechanism of citalopram and cocaine interactions with neurotransmitter transporters.

Ravna AW, Sylte I, Dahl SG.

J Pharmacol Exp Ther. 2003 Oct;307(1):34-41. Epub 2003 Aug 27.

10.

Homology modeling of the serotonin transporter: insights into the primary escitalopram-binding site.

Jørgensen AM, Tagmose L, Jørgensen AM, Topiol S, Sabio M, Gundertofte K, Bøgesø KP, Peters GH.

ChemMedChem. 2007 Jun;2(6):815-26.

PMID:
17405130
11.

[Escitalopram and citalopram: the unexpected role of the R-enantiomer].

Jacquot C, David DJ, Gardier AM, Sánchez C.

Encephale. 2007 Mar-Apr;33(2):179-87. Review. French.

PMID:
17675913
12.

Location of the antidepressant binding site in the serotonin transporter: importance of Ser-438 in recognition of citalopram and tricyclic antidepressants.

Andersen J, Taboureau O, Hansen KB, Olsen L, Egebjerg J, Strømgaard K, Kristensen AS.

J Biol Chem. 2009 Apr 10;284(15):10276-84. doi: 10.1074/jbc.M806907200. Epub 2009 Feb 12.

14.

[Second generation SSRIS: human monoamine transporter binding profile of escitalopram and R-fluoxetine].

Owens JM, Knight DL, Nemeroff CB.

Encephale. 2002 Jul-Aug;28(4):350-5. French.

PMID:
12232544
15.

Molecular dynamics simulations of Na+/Cl(-)-dependent neurotransmitter transporters in a membrane-aqueous system.

Jørgensen AM, Tagmose L, Jørgensen AM, Bøgesø KP, Peters GH.

ChemMedChem. 2007 Jun;2(6):827-40.

PMID:
17436258
16.

Second-generation SSRIs: human monoamine transporter binding profile of escitalopram and R-fluoxetine.

Owens MJ, Knight DL, Nemeroff CB.

Biol Psychiatry. 2001 Sep 1;50(5):345-50.

PMID:
11543737
17.

A homology model of SERT based on the LeuT(Aa) template.

Ravna AW, Jaronczyk M, Sylte I.

Bioorg Med Chem Lett. 2006 Nov 1;16(21):5594-7. Epub 2006 Aug 17.

PMID:
16919451
18.

Kinetic and thermodynamic assessment of binding of serotonin transporter inhibitors.

Martin RS, Henningsen RA, Suen A, Apparsundaram S, Leung B, Jia Z, Kondru RK, Milla ME.

J Pharmacol Exp Ther. 2008 Dec;327(3):991-1000. doi: 10.1124/jpet.108.142307. Epub 2008 Sep 18.

20.

Binding and orientation of tricyclic antidepressants within the central substrate site of the human serotonin transporter.

Sinning S, Musgaard M, Jensen M, Severinsen K, Celik L, Koldsø H, Meyer T, Bols M, Jensen HH, Schiøtt B, Wiborg O.

J Biol Chem. 2010 Mar 12;285(11):8363-74. doi: 10.1074/jbc.M109.045401. Epub 2009 Nov 30.

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