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Items: 1 to 20 of 117

1.

Impact of disease-causing SUR1 mutations on the KATP channel subunit interface probed with a rhodamine protection assay.

Hosy E, Dupuis JP, Vivaudou M.

J Biol Chem. 2010 Jan 29;285(5):3084-91. doi: 10.1074/jbc.M109.043307. Epub 2009 Nov 20.

2.

N-terminal transmembrane domain of SUR1 controls gating of Kir6.2 by modulating channel sensitivity to PIP2.

Pratt EB, Tewson P, Bruederle CE, Skach WR, Shyng SL.

J Gen Physiol. 2011 Mar;137(3):299-314. doi: 10.1085/jgp.201010557. Epub 2011 Feb 14.

3.

Remodelling of the SUR-Kir6.2 interface of the KATP channel upon ATP binding revealed by the conformational blocker rhodamine 123.

Hosy E, Dérand R, Revilloud J, Vivaudou M.

J Physiol. 2007 Jul 1;582(Pt 1):27-39. Epub 2007 May 17.

4.
5.

The Kir6.2-F333I mutation differentially modulates KATP channels composed of SUR1 or SUR2 subunits.

Tammaro P, Ashcroft F.

J Physiol. 2007 Jun 15;581(Pt 3):1259-69. Epub 2007 Mar 29.

6.

A heterozygous activating mutation in the sulphonylurea receptor SUR1 (ABCC8) causes neonatal diabetes.

Proks P, Arnold AL, Bruining J, Girard C, Flanagan SE, Larkin B, Colclough K, Hattersley AT, Ashcroft FM, Ellard S.

Hum Mol Genet. 2006 Jun 1;15(11):1793-800. Epub 2006 Apr 13.

PMID:
16613899
7.

Mechanism of action of a sulphonylurea receptor SUR1 mutation (F132L) that causes DEND syndrome.

Proks P, Shimomura K, Craig TJ, Girard CA, Ashcroft FM.

Hum Mol Genet. 2007 Aug 15;16(16):2011-9. Epub 2007 Jun 21.

PMID:
17584766
8.

Analysis of the differential modulation of sulphonylurea block of beta-cell and cardiac ATP-sensitive K+ (K(ATP)) channels by Mg-nucleotides.

Reimann F, Dabrowski M, Jones P, Gribble FM, Ashcroft FM.

J Physiol. 2003 Feb 15;547(Pt 1):159-68. Epub 2003 Jan 10.

9.

Regulation of KATP channel expression and activity by the SUR1 nucleotide binding fold 1.

Masia R, Caputa G, Nichols CG.

Channels (Austin). 2007 Jul-Aug;1(4):315-23. Epub 2007 Sep 25.

PMID:
18708750
10.

A conserved tryptophan at the membrane-water interface acts as a gatekeeper for Kir6.2/SUR1 channels and causes neonatal diabetes when mutated.

Männikkö R, Stansfeld PJ, Ashcroft AS, Hattersley AT, Sansom MS, Ellard S, Ashcroft FM.

J Physiol. 2011 Jul 1;589(Pt 13):3071-83. doi: 10.1113/jphysiol.2011.209700. Epub 2011 May 3.

11.

Three C-terminal residues from the sulphonylurea receptor contribute to the functional coupling between the K(ATP) channel subunits SUR2A and Kir6.2.

Dupuis JP, Revilloud J, Moreau CJ, Vivaudou M.

J Physiol. 2008 Jul 1;586(13):3075-85. doi: 10.1113/jphysiol.2008.152744. Epub 2008 May 1.

12.

Sulfonylurea receptors type 1 and 2A randomly assemble to form heteromeric KATP channels of mixed subunit composition.

Chan KW, Wheeler A, Csanády L.

J Gen Physiol. 2008 Jan;131(1):43-58. Epub 2007 Dec 17.

13.

Review. SUR1: a unique ATP-binding cassette protein that functions as an ion channel regulator.

Aittoniemi J, Fotinou C, Craig TJ, de Wet H, Proks P, Ashcroft FM.

Philos Trans R Soc Lond B Biol Sci. 2009 Jan 27;364(1514):257-67. doi: 10.1098/rstb.2008.0142. Review.

14.
15.

Mutations of the same conserved glutamate residue in NBD2 of the sulfonylurea receptor 1 subunit of the KATP channel can result in either hyperinsulinism or neonatal diabetes.

Männikkö R, Flanagan SE, Sim X, Segal D, Hussain K, Ellard S, Hattersley AT, Ashcroft FM.

Diabetes. 2011 Jun;60(6):1813-22. doi: 10.2337/db10-1583.

16.
17.

Compound heterozygous mutations in the SUR1 (ABCC 8) subunit of pancreatic K(ATP) channels cause neonatal diabetes by perturbing the coupling between Kir6.2 and SUR1 subunits.

Lin YW, Akrouh A, Hsu Y, Hughes N, Nichols CG, De León DD.

Channels (Austin). 2012 Mar-Apr;6(2):133-8. doi: 10.4161/chan.19980. Epub 2012 Mar 1.

18.

Activation of the K(ATP) channel by Mg-nucleotide interaction with SUR1.

Proks P, de Wet H, Ashcroft FM.

J Gen Physiol. 2010 Oct;136(4):389-405. doi: 10.1085/jgp.201010475.

19.

Sulfonylurea receptor 1 mutations that cause opposite insulin secretion defects with chemical chaperone exposure.

Pratt EB, Yan FF, Gay JW, Stanley CA, Shyng SL.

J Biol Chem. 2009 Mar 20;284(12):7951-9. doi: 10.1074/jbc.M807012200. Epub 2009 Jan 16.

20.

Neonatal diabetes caused by mutations in sulfonylurea receptor 1: interplay between expression and Mg-nucleotide gating defects of ATP-sensitive potassium channels.

Zhou Q, Garin I, Castaño L, Argente J, Muñoz-Calvo MT, Perez de Nanclares G, Shyng SL.

J Clin Endocrinol Metab. 2010 Dec;95(12):E473-8. doi: 10.1210/jc.2010-1231. Epub 2010 Sep 1.

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