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Items: 1 to 20 of 88


Investigating bacterial sources of toxicity as an environmental contributor to dopaminergic neurodegeneration.

Caldwell KA, Tucci ML, Armagost J, Hodges TW, Chen J, Memon SB, Blalock JE, DeLeon SM, Findlay RH, Ruan Q, Webber PJ, Standaert DG, Olson JB, Caldwell GA.

PLoS One. 2009 Oct 6;4(10):e7227. doi: 10.1371/journal.pone.0007227.


Mitochondrial dysfunction, oxidative stress, and neurodegeneration elicited by a bacterial metabolite in a C. elegans Parkinson's model.

Ray A, Martinez BA, Berkowitz LA, Caldwell GA, Caldwell KA.

Cell Death Dis. 2014 Jan 9;5:e984. doi: 10.1038/cddis.2013.513.


Reprint of: revisiting oxidative stress and mitochondrial dysfunction in the pathogenesis of Parkinson disease-resemblance to the effect of amphetamine drugs of abuse.

Perfeito R, Cunha-Oliveira T, Rego AC.

Free Radic Biol Med. 2013 Sep;62:186-201. doi: 10.1016/j.freeradbiomed.2013.05.042. Epub 2013 Jun 3. Review.


Application of a C. elegans dopamine neuron degeneration assay for the validation of potential Parkinson's disease genes.

Berkowitz LA, Hamamichi S, Knight AL, Harrington AJ, Caldwell GA, Caldwell KA.

J Vis Exp. 2008 Jul 18;(17). pii: 835. doi: 10.3791/835.


Bacterial artificial chromosome transgenic mice expressing a truncated mutant parkin exhibit age-dependent hypokinetic motor deficits, dopaminergic neuron degeneration, and accumulation of proteinase K-resistant alpha-synuclein.

Lu XH, Fleming SM, Meurers B, Ackerson LC, Mortazavi F, Lo V, Hernandez D, Sulzer D, Jackson GR, Maidment NT, Chesselet MF, Yang XW.

J Neurosci. 2009 Feb 18;29(7):1962-76. doi: 10.1523/JNEUROSCI.5351-08.2009.


Torsin-mediated protection from cellular stress in the dopaminergic neurons of Caenorhabditis elegans.

Cao S, Gelwix CC, Caldwell KA, Caldwell GA.

J Neurosci. 2005 Apr 13;25(15):3801-12.


Alpha-synuclein aggregation and cell death triggered by energy deprivation and dopamine overload are counteracted by D2/D3 receptor activation.

Bellucci A, Collo G, Sarnico I, Battistin L, Missale C, Spano P.

J Neurochem. 2008 Jul;106(2):560-77. doi: 10.1111/j.1471-4159.2008.05406.x. Epub 2008 Apr 10.


Acetaminophen attenuates dopamine neuron degeneration in animal models of Parkinson's disease.

Locke CJ, Fox SA, Caldwell GA, Caldwell KA.

Neurosci Lett. 2008 Jul 11;439(2):129-33. doi: 10.1016/j.neulet.2008.05.003. Epub 2008 May 7.


Dopamine and α-synuclein dysfunction in Smad3 null mice.

Tapia-González S, Giráldez-Pérez RM, Cuartero MI, Casarejos MJ, Mena MÁ, Wang XF, Sánchez-Capelo A.

Mol Neurodegener. 2011 Oct 13;6:72. doi: 10.1186/1750-1326-6-72.


Fine structure and biochemical mechanisms underlying nigrostriatal inclusions and cell death after proteasome inhibition.

Fornai F, Lenzi P, Gesi M, Ferrucci M, Lazzeri G, Busceti CL, Ruffoli R, Soldani P, Ruggieri S, Alessandri MG, Paparelli A.

J Neurosci. 2003 Oct 1;23(26):8955-66.


The role of ubiquitin linkages on alpha-synuclein induced-toxicity in a Drosophila model of Parkinson's disease.

Lee FK, Wong AK, Lee YW, Wan OW, Chan HY, Chung KK.

J Neurochem. 2009 Jul;110(1):208-19. doi: 10.1111/j.1471-4159.2009.06124.x. Epub 2009 Apr 27.


Does proteasome [corrected] inhibition decrease or accelerate toxin-induced dopaminergic neurodegeneration?

Setsuie R, Kabuta T, Wada K.

J Pharmacol Sci. 2005 Mar;97(3):457-60. Epub 2005 Mar 12. Erratum in: J Pharmacol Sci. 2006 Jun;101(2):182.


Valproic acid ameliorates C. elegans dopaminergic neurodegeneration with implications for ERK-MAPK signaling.

Kautu BB, Carrasquilla A, Hicks ML, Caldwell KA, Caldwell GA.

Neurosci Lett. 2013 Apr 29;541:116-9. doi: 10.1016/j.neulet.2013.02.026. Epub 2013 Feb 26.


Elevated alpha-synuclein mRNA levels in individual UV-laser-microdissected dopaminergic substantia nigra neurons in idiopathic Parkinson's disease.

Gründemann J, Schlaudraff F, Haeckel O, Liss B.

Nucleic Acids Res. 2008 Apr;36(7):e38. doi: 10.1093/nar/gkn084. Epub 2008 Mar 10.


Endogenous dopamine (DA) renders dopaminergic cells vulnerable to challenge of proteasome inhibitor MG132.

Zhou Z, Kerk S, Meng Lim T.

Free Radic Res. 2008 May;42(5):456-66. doi: 10.1080/10715760802005177.


Gene-by-environment interactions that disrupt mitochondrial homeostasis cause neurodegeneration in C. elegans Parkinson's models.

Kim H, Perentis RJ, Caldwell GA, Caldwell KA.

Cell Death Dis. 2018 May 1;9(5):555. doi: 10.1038/s41419-018-0619-5.


Neuroinflammation and oxidation/nitration of alpha-synuclein linked to dopaminergic neurodegeneration.

Gao HM, Kotzbauer PT, Uryu K, Leight S, Trojanowski JQ, Lee VM.

J Neurosci. 2008 Jul 23;28(30):7687-98. doi: 10.1523/JNEUROSCI.0143-07.2008.

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